Immune checkpoint inhibitor induced nephrotoxicity: An ongoing challenge.
ICI-induced acute kidney injury
immune checkpoint inhibitors
immune-related adverse events
multidisciplinary management
nephrotoxicity
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
08
2022
accepted:
05
12
2022
entrez:
6
1
2023
pubmed:
7
1
2023
medline:
7
1
2023
Statut:
epublish
Résumé
Although immune checkpoint inhibitors (ICIs) have dramatically revolutionized the field of oncology over the last decade, severe immune-related adverse events (irAEs) are potentially life-threatening. In comparison with toxicities involving the skin, gastrointestinal tract and endocrine system, nephrotoxicity is less common but often underestimated due to difficult diagnosis. Management usually consists of treatment discontinuation and/or corticosteroid use. In this review, we summarize current knowledge of ICI-induced nephrotoxicity, evaluating drawbacks and future perspectives.
Identifiants
pubmed: 36606052
doi: 10.3389/fmed.2022.1014257
pmc: PMC9807763
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1014257Informations de copyright
Copyright © 2022 Catalano, Roviello, Galli, Santi and Nesi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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