Viral subversion of the cell polarity regulator Scribble.
PDZ domain
Scribble
cell polarity
virology
Journal
Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897
Informations de publication
Date de publication:
27 02 2023
27 02 2023
Historique:
received:
19
10
2022
revised:
08
12
2022
accepted:
12
12
2022
pubmed:
7
1
2023
medline:
3
3
2023
entrez:
6
1
2023
Statut:
ppublish
Résumé
Scribble is a scaffolding protein that regulates key events such as cell polarity, tumorigenesis and neuronal signalling. Scribble belongs to the LAP family which comprise of 16 Leucine Rich Repeats (LRR) at the N-terminus, two LAP Specific Domains (LAPSD) and four PSD-95/Discs-large/ZO-1 (PDZ) domains at the C-terminus. The four PDZ domains have been shown to be key for a range of protein-protein interactions and have been identified to be crucial mediators for the vast majority of Scribble interactions, particularly via PDZ Binding Motifs (PBMs) often found at the C-terminus of interacting proteins. Dysregulation of Scribble is associated with poor prognosis in viral infections due to subversion of multiple cell signalling pathways by viral effector proteins. Here, we review the molecular details of the interplay between Scribble and viral effector proteins that provide insight into the potential modes of regulation of Scribble mediated polarity signalling.
Identifiants
pubmed: 36606695
pii: 232418
doi: 10.1042/BST20221067
pmc: PMC9987997
doi:
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
415-426Informations de copyright
© 2023 The Author(s).
Références
Virus Genes. 2008 Oct;37(2):231-40
pubmed: 18661220
Viruses. 2022 Mar 11;14(3):
pubmed: 35336989
J Biol Chem. 1998 Aug 21;273(34):21980-7
pubmed: 9705339
FEBS J. 2012 Oct;279(19):3530-3537
pubmed: 22805590
Adv Ther (Weinh). 2019 Jul;2(7):1800143
pubmed: 32313833
Genes Cells. 2006 Apr;11(4):453-64
pubmed: 16611247
J Mol Biol. 2018 Sep 28;430(19):3481-3503
pubmed: 29680664
Front Genet. 2022 May 25;13:872700
pubmed: 35692812
J Med Virol. 2006 Apr;78(4):501-7
pubmed: 16482544
Virus Res. 2009 Aug;143(2):195-208
pubmed: 19540281
Iran J Basic Med Sci. 2013 Mar;16(3):179-95
pubmed: 24470860
Philos Trans R Soc Lond B Biol Sci. 2013 Sep 23;368(1629):20130419
pubmed: 24062591
Adv Virus Res. 2009;74:41-101
pubmed: 19698895
Emerg Infect Dis. 2005 Jul;11(7):1036-41
pubmed: 16022777
Mol Biol Cell. 2013 Jul;24(14):2171-85
pubmed: 23699395
Small GTPases. 2010 Sep;1(2):108-112
pubmed: 21686263
Papillomavirus Res. 2016 Dec;2:70-77
pubmed: 29074188
J Virol. 2017 Jan 18;91(3):
pubmed: 27881649
Commun Biol. 2021 Jun 11;4(1):724
pubmed: 34117354
PLoS Biol. 2008 Sep 30;6(9):e239
pubmed: 18828675
Biol Chem. 2009 Apr;390(4):319-23
pubmed: 19199833
Science. 2000 Jul 7;289(5476):113-6
pubmed: 10884224
Virus Genes. 2010 Oct;41(2):149-57
pubmed: 20526659
Nat Struct Mol Biol. 2004 Nov;11(11):1122-7
pubmed: 15475968
Immunity. 2005 Jun;22(6):737-48
pubmed: 15963788
J Cell Biol. 2005 Dec 19;171(6):1061-71
pubmed: 16344308
FEBS Lett. 2001 Dec 14;509(3):457-62
pubmed: 11749973
Cancer Res Treat. 2005 Dec;37(6):319-24
pubmed: 19956366
Cancer Sci. 2013 Mar;104(3):313-20
pubmed: 23279616
J Biol Chem. 2018 Mar 23;293(12):4519-4531
pubmed: 29378849
PLoS Pathog. 2018 Mar 22;14(3):e1006933
pubmed: 29566098
J Gen Virol. 2008 Oct;89(Pt 10):2359-2376
pubmed: 18796704
Biochem J. 2011 Oct 15;439(2):195-205
pubmed: 21954943
Oncogene. 2001 Nov 26;20(54):7874-87
pubmed: 11753670
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4381-6
pubmed: 18334632
J Virol. 2011 Oct;85(20):10639-48
pubmed: 21849460
Curr Biol. 2011 Jan 11;21(1):79-86
pubmed: 21185191
Cell. 2008 Nov 28;135(5):865-78
pubmed: 19041750
Mol Cell Biol. 2000 Nov;20(21):8244-53
pubmed: 11027293
Structure. 2012 Apr 4;20(4):604-17
pubmed: 22483108
J Virol. 2011 Feb;85(4):1757-64
pubmed: 21123374
Virus Res. 2005 Aug;111(2):161-74
pubmed: 15871909
J Virol. 2013 Oct;87(19):10612-27
pubmed: 23885072
FEBS Lett. 2019 Mar;593(5):533-542
pubmed: 30659601
J Biol Chem. 2017 Dec 15;292(50):20425-20436
pubmed: 29061852
Cancer Sci. 2017 Jul;108(7):1303-1309
pubmed: 28440909
Viruses. 2018 Jun 28;10(7):
pubmed: 29958443
J Cell Biol. 2019 Mar 4;218(3):742-756
pubmed: 30598480
J Leukoc Biol. 2018 Apr;103(4):731-738
pubmed: 29345359
J Am Chem Soc. 2005 Oct 12;127(40):14072-9
pubmed: 16201829
Int J Cancer. 2017 Aug 15;141(4):664-670
pubmed: 28369882
FEBS J. 2019 Dec;286(24):4910-4925
pubmed: 31317644
J Cell Biochem. 2006 Oct 1;99(2):647-64
pubmed: 16791850
J Biol Chem. 2007 Nov 9;282(45):33132-41
pubmed: 17855372
Oncogene. 2004 Oct 21;23(49):8033-9
pubmed: 15378012
Virology. 2012 Jan 5;422(1):114-24
pubmed: 22056390
Cell Microbiol. 2008 Mar;10(3):696-712
pubmed: 18042258
J Virol. 2015 Feb;89(3):1579-86
pubmed: 25410862
J Virol. 2003 Jun;77(12):6957-64
pubmed: 12768014
Nature. 2000 Feb 10;403(6770):676-80
pubmed: 10688207
J Virol. 2013 May;87(9):4861-71
pubmed: 23408626
Cancers (Basel). 2021 Sep 04;13(17):
pubmed: 34503271
Essays Biochem. 2012;53:141-68
pubmed: 22928514
Cell Microbiol. 2012 Jul;14(7):994-1002
pubmed: 22329740
Virol J. 2017 Apr 21;14(1):83
pubmed: 28431572
Biochem J. 2022 Jun 30;479(12):1303-1315
pubmed: 35670457
Annu Rev Pathol. 2008;3:499-522
pubmed: 18039138
Science. 1997 Jan 3;275(5296):73-7
pubmed: 8974395
FEBS J. 2023 Jan 6;:
pubmed: 36609831
Antiviral Res. 2003 Jan;57(1-2):129-46
pubmed: 12615309
PLoS Pathog. 2016 Aug 02;12(8):e1005766
pubmed: 27483446
FEBS J. 2023 Feb;290(4):974-987
pubmed: 36029163
Virology. 2008 Jul 5;376(2):371-8
pubmed: 18452965
J Mol Biol. 2018 Sep 28;430(19):3585-3612
pubmed: 29409995
Biochem J. 2013 Oct 1;455(1):1-14
pubmed: 24028161
Nat Cell Biol. 2000 Aug;2(8):E141-3
pubmed: 10934483
Virology. 2004 Mar 1;320(1):52-62
pubmed: 15003862
Cancer Lett. 2014 Apr 10;345(2):210-5
pubmed: 23871966
Science. 1999 Apr 30;284(5415):812-5
pubmed: 10221915
Sci STKE. 2003 Apr 22;2003(179):RE7
pubmed: 12709532
J Viral Hepat. 2000 Jan;7(1):2-14
pubmed: 10718937
Biochem J. 2021 Apr 16;478(7):1321-1332
pubmed: 33684218
J Virol. 2010 Nov;84(21):11164-74
pubmed: 20702615
Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24294-24304
pubmed: 32929026
Virus Res. 2012 Oct;169(1):54-62
pubmed: 22796133
Oncogene. 2005 Sep 15;24(41):6222-30
pubmed: 16103886
J Cell Sci. 2004 Dec 1;117(Pt 25):6061-70
pubmed: 15536119
FASEB J. 2019 Oct;33(10):10607-10617
pubmed: 31336050
Oncogene. 2000 Nov 2;19(46):5270-80
pubmed: 11077444
Protein Sci. 2010 May;19(5):914-28
pubmed: 20196074
J Virol. 2011 Nov;85(22):11544-56
pubmed: 21775458
Biochem J. 2015 May 15;468(1):133-44
pubmed: 25734361
Viruses. 2017 Nov 23;9(12):
pubmed: 29168728
J Virol. 2007 Apr;81(8):4080-90
pubmed: 17287269
Oncogene. 2020 Nov;39(47):7019-7033
pubmed: 32999444
Nat Rev Cancer. 2010 Aug;10(8):550-60
pubmed: 20592731
Virus Genes. 2010 Apr;40(2):193-9
pubmed: 20069350
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2542-7
pubmed: 24550280
J Gen Virol. 2020 Sep;101(9):954-962
pubmed: 30810519
Virology. 2011 Jun 5;414(2):137-45
pubmed: 21489588
Tumour Biol. 2016 Sep;37(9):12387-12396
pubmed: 27315218
Mol Cell Neurosci. 2010 Jul;44(3):260-71
pubmed: 20363326