Volumetric Enhancing Tumor Burden at CT to Predict Survival Outcomes in Patients with Neuroendocrine Liver Metastases after Intra-arterial Treatment.

Male Humans Middle Aged Tumor Burden Retrospective Studies Treatment Outcome Chemoembolization, Therapeutic / methods Liver Neoplasms / diagnostic imaging Tomography, X-Ray Computed
Abdomen/GI CT Chemoembolization Embolization Liver

Journal

Radiology. Imaging cancer
ISSN: 2638-616X
Titre abrégé: Radiol Imaging Cancer
Pays: United States
ID NLM: 101765309

Informations de publication

Date de publication:
01 2023
Historique:
entrez: 6 1 2023
pubmed: 7 1 2023
medline: 11 1 2023
Statut: ppublish

Résumé

Purpose To investigate whether liver enhancing tumor burden (LETB) assessed at contrast-enhanced CT indicates early response and helps predict survival outcomes in patients with multifocal neuroendocrine liver metastases (NELM) after intra-arterial treatment. Materials and Methods This retrospective study included patients with NELM who underwent intra-arterial treatment with transarterial embolization (TAE) or chemoembolization (TACE) between April 2006 and December 2018. Tumor response in treated NELM was evaluated by using the Response Evaluation Criteria in Solid Tumors (RECIST) and modified RECIST (mRECIST). LETB was measured as attenuation 2 SDs greater than that of a region of interest in the nontumoral liver parenchyma. Overall survival (OS); time to unTA(C)Eable progression, defined as the time from the initial treatment until the time when intra-arterial treatments were considered technically unfeasible, either not recommended by the multidisciplinary tumor board or until death; and hepatic and whole-body progression-free survival (PFS) were evaluated using multivariable Cox proportional hazards analyses, the Kaplan-Meier method, and log-rank test. Results The study included 119 patients (mean age, 60 years ± 11 [SD]; 61 men) who underwent 161 treatments. A median LETB change of -25.8% best discriminated OS (83 months in responders vs 51 months in nonresponders;

Identifiants

DOI: 10.1148/rycan.220051 PMID: 36607243 PMC: PMC9896229
pubmed: 36607243
doi: 10.1148/rycan.220051
pmc: PMC9896229
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e220051

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Auteurs

Jessica Assouline (J)

From the Departments of Radiology (J.A., R.C., G.P., M.D., L.R., M.P.V., V.V., M.R.), Pancreatology and Digestive Oncology (L.d.M., O.H., P.R.), and Pathology (J.C.), Université de Paris, ENETS Centre of Excellence, Beaujon Hospital (APHP), Clichy, France; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University Hospital Paolo Giaccone, Palermo, Italy (R.C., G.P.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, Italy (R.C.); Université de Paris, Centre of Research on Inflammation, INSERM U1149, Paris, France (L.d.M., M.D., J.C., V.V., M.R.); Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), Villejuif, France (L.T.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).

Roberto Cannella (R)

From the Departments of Radiology (J.A., R.C., G.P., M.D., L.R., M.P.V., V.V., M.R.), Pancreatology and Digestive Oncology (L.d.M., O.H., P.R.), and Pathology (J.C.), Université de Paris, ENETS Centre of Excellence, Beaujon Hospital (APHP), Clichy, France; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University Hospital Paolo Giaccone, Palermo, Italy (R.C., G.P.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, Italy (R.C.); Université de Paris, Centre of Research on Inflammation, INSERM U1149, Paris, France (L.d.M., M.D., J.C., V.V., M.R.); Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), Villejuif, France (L.T.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
ORCID: 0000-0002-3808-0785

Giorgia Porrello (G)

From the Departments of Radiology (J.A., R.C., G.P., M.D., L.R., M.P.V., V.V., M.R.), Pancreatology and Digestive Oncology (L.d.M., O.H., P.R.), and Pathology (J.C.), Université de Paris, ENETS Centre of Excellence, Beaujon Hospital (APHP), Clichy, France; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University Hospital Paolo Giaccone, Palermo, Italy (R.C., G.P.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, Italy (R.C.); Université de Paris, Centre of Research on Inflammation, INSERM U1149, Paris, France (L.d.M., M.D., J.C., V.V., M.R.); Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), Villejuif, France (L.T.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
ORCID: 0000-0003-1617-5609

Louis de Mestier (L)

From the Departments of Radiology (J.A., R.C., G.P., M.D., L.R., M.P.V., V.V., M.R.), Pancreatology and Digestive Oncology (L.d.M., O.H., P.R.), and Pathology (J.C.), Université de Paris, ENETS Centre of Excellence, Beaujon Hospital (APHP), Clichy, France; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University Hospital Paolo Giaccone, Palermo, Italy (R.C., G.P.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, Italy (R.C.); Université de Paris, Centre of Research on Inflammation, INSERM U1149, Paris, France (L.d.M., M.D., J.C., V.V., M.R.); Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), Villejuif, France (L.T.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).

Marco Dioguardi Burgio (M)

From the Departments of Radiology (J.A., R.C., G.P., M.D., L.R., M.P.V., V.V., M.R.), Pancreatology and Digestive Oncology (L.d.M., O.H., P.R.), and Pathology (J.C.), Université de Paris, ENETS Centre of Excellence, Beaujon Hospital (APHP), Clichy, France; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University Hospital Paolo Giaccone, Palermo, Italy (R.C., G.P.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, Italy (R.C.); Université de Paris, Centre of Research on Inflammation, INSERM U1149, Paris, France (L.d.M., M.D., J.C., V.V., M.R.); Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), Villejuif, France (L.T.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
ORCID: 0000-0002-3243-6699

Lucas Raynaud (L)

From the Departments of Radiology (J.A., R.C., G.P., M.D., L.R., M.P.V., V.V., M.R.), Pancreatology and Digestive Oncology (L.d.M., O.H., P.R.), and Pathology (J.C.), Université de Paris, ENETS Centre of Excellence, Beaujon Hospital (APHP), Clichy, France; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University Hospital Paolo Giaccone, Palermo, Italy (R.C., G.P.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, Italy (R.C.); Université de Paris, Centre of Research on Inflammation, INSERM U1149, Paris, France (L.d.M., M.D., J.C., V.V., M.R.); Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), Villejuif, France (L.T.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).

Olivia Hentic (O)

From the Departments of Radiology (J.A., R.C., G.P., M.D., L.R., M.P.V., V.V., M.R.), Pancreatology and Digestive Oncology (L.d.M., O.H., P.R.), and Pathology (J.C.), Université de Paris, ENETS Centre of Excellence, Beaujon Hospital (APHP), Clichy, France; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University Hospital Paolo Giaccone, Palermo, Italy (R.C., G.P.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, Italy (R.C.); Université de Paris, Centre of Research on Inflammation, INSERM U1149, Paris, France (L.d.M., M.D., J.C., V.V., M.R.); Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), Villejuif, France (L.T.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).

Jérôme Cros (J)

From the Departments of Radiology (J.A., R.C., G.P., M.D., L.R., M.P.V., V.V., M.R.), Pancreatology and Digestive Oncology (L.d.M., O.H., P.R.), and Pathology (J.C.), Université de Paris, ENETS Centre of Excellence, Beaujon Hospital (APHP), Clichy, France; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University Hospital Paolo Giaccone, Palermo, Italy (R.C., G.P.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, Italy (R.C.); Université de Paris, Centre of Research on Inflammation, INSERM U1149, Paris, France (L.d.M., M.D., J.C., V.V., M.R.); Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), Villejuif, France (L.T.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).

Lambros Tselikas (L)

From the Departments of Radiology (J.A., R.C., G.P., M.D., L.R., M.P.V., V.V., M.R.), Pancreatology and Digestive Oncology (L.d.M., O.H., P.R.), and Pathology (J.C.), Université de Paris, ENETS Centre of Excellence, Beaujon Hospital (APHP), Clichy, France; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University Hospital Paolo Giaccone, Palermo, Italy (R.C., G.P.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, Italy (R.C.); Université de Paris, Centre of Research on Inflammation, INSERM U1149, Paris, France (L.d.M., M.D., J.C., V.V., M.R.); Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), Villejuif, France (L.T.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
ORCID: 0000-0001-7732-6293

Philippe Ruszniewski (P)

From the Departments of Radiology (J.A., R.C., G.P., M.D., L.R., M.P.V., V.V., M.R.), Pancreatology and Digestive Oncology (L.d.M., O.H., P.R.), and Pathology (J.C.), Université de Paris, ENETS Centre of Excellence, Beaujon Hospital (APHP), Clichy, France; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University Hospital Paolo Giaccone, Palermo, Italy (R.C., G.P.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, Italy (R.C.); Université de Paris, Centre of Research on Inflammation, INSERM U1149, Paris, France (L.d.M., M.D., J.C., V.V., M.R.); Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), Villejuif, France (L.T.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).

Marie-Pierre Vullierme (MP)

From the Departments of Radiology (J.A., R.C., G.P., M.D., L.R., M.P.V., V.V., M.R.), Pancreatology and Digestive Oncology (L.d.M., O.H., P.R.), and Pathology (J.C.), Université de Paris, ENETS Centre of Excellence, Beaujon Hospital (APHP), Clichy, France; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University Hospital Paolo Giaccone, Palermo, Italy (R.C., G.P.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, Italy (R.C.); Université de Paris, Centre of Research on Inflammation, INSERM U1149, Paris, France (L.d.M., M.D., J.C., V.V., M.R.); Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), Villejuif, France (L.T.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).

Valérie Vilgrain (V)

From the Departments of Radiology (J.A., R.C., G.P., M.D., L.R., M.P.V., V.V., M.R.), Pancreatology and Digestive Oncology (L.d.M., O.H., P.R.), and Pathology (J.C.), Université de Paris, ENETS Centre of Excellence, Beaujon Hospital (APHP), Clichy, France; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University Hospital Paolo Giaccone, Palermo, Italy (R.C., G.P.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, Italy (R.C.); Université de Paris, Centre of Research on Inflammation, INSERM U1149, Paris, France (L.d.M., M.D., J.C., V.V., M.R.); Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), Villejuif, France (L.T.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
ORCID: 0000-0002-3568-7725

Rafael Duran (R)

From the Departments of Radiology (J.A., R.C., G.P., M.D., L.R., M.P.V., V.V., M.R.), Pancreatology and Digestive Oncology (L.d.M., O.H., P.R.), and Pathology (J.C.), Université de Paris, ENETS Centre of Excellence, Beaujon Hospital (APHP), Clichy, France; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University Hospital Paolo Giaccone, Palermo, Italy (R.C., G.P.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, Italy (R.C.); Université de Paris, Centre of Research on Inflammation, INSERM U1149, Paris, France (L.d.M., M.D., J.C., V.V., M.R.); Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), Villejuif, France (L.T.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
ORCID: 0000-0003-2610-9517

Maxime Ronot (M)

From the Departments of Radiology (J.A., R.C., G.P., M.D., L.R., M.P.V., V.V., M.R.), Pancreatology and Digestive Oncology (L.d.M., O.H., P.R.), and Pathology (J.C.), Université de Paris, ENETS Centre of Excellence, Beaujon Hospital (APHP), Clichy, France; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University Hospital Paolo Giaccone, Palermo, Italy (R.C., G.P.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, Italy (R.C.); Université de Paris, Centre of Research on Inflammation, INSERM U1149, Paris, France (L.d.M., M.D., J.C., V.V., M.R.); Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), Villejuif, France (L.T.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
ORCID: 0000-0001-7464-3939

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Volumetric Enhancing Tumor Burden at CT to...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Volumetric Enhancing Tumor Burden at CT to...
questionsmedicales.fr › Techniques d'investigation › Charge tumorale › Volumetric Enhancing Tumor Burden at CT to...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Volumetric Enhancing Tumor Burden at CT to...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Volumetric Enhancing Tumor Burden at CT to...
questionsmedicales.fr › Thérapeutique › Occlusion thérapeutique › Embolisation thérapeutique › Chimioembolisation thérapeutique › Volumetric Enhancing Tumor Burden at CT to...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Volumetric Enhancing Tumor Burden at CT to...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Volumetric Enhancing Tumor Burden at CT to...