Normalization of Liver Physiological Uptake as a Response Marker to Treatment in Prostate Cancer Liver Metastases Appearing as Photopenic on Baseline 18F-Fluorocholine PET/CT.
Journal
Clinical nuclear medicine
ISSN: 1536-0229
Titre abrégé: Clin Nucl Med
Pays: United States
ID NLM: 7611109
Informations de publication
Date de publication:
01 Feb 2023
01 Feb 2023
Historique:
entrez:
6
1
2023
pubmed:
7
1
2023
medline:
11
1
2023
Statut:
ppublish
Résumé
In a 54-year-old patient referred for 18F-fluorocholine (FCH) baseline PET/CT before chemotherapy for biopsy-proven liver metastases, FCH PET/CT demonstrated multiple hypodense hepatic lesions with no FCH uptake and 2 positive bone metastases. FCH PET/CT performed after 6 cycles of docetaxel demonstrated a near normalization of the physiological uptake in the area of the sterilized liver metastases, which was confirmed by a drop in prostate-specific antigen and a complete metabolic response in the bone metastases. The present case demonstrates a new pattern of response defined by a reverse phenomenon from photopenic to normal uptake in responding liver metastases.
Identifiants
pubmed: 36607367
doi: 10.1097/RLU.0000000000004420
pii: 00003072-202302000-00015
doi:
Substances chimiques
fluorocholine
6029HGL0QP
fluoromethylcholine
0
Choline
N91BDP6H0X
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
182-183Informations de copyright
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest and sources of funding: none declared.
Références
Bubendorf L, Schopfer A, Wagner U, et al. Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients. Hum Pathol . 2000;31:578–583.
Lamothe F, Kovi J, Heshmat MY, et al. Dissemination of prostatic carcinoma: an autopsy study. J Natl Med Assoc . 1986;78:1083–1086.
Gandaglia G, Abdollah F, Schiffmann J, et al. Distribution of metastatic sites in patients with prostate cancer: a population-based analysis. Prostate . 2014;74:210–216.
Tanaka T, Yang M, Froemming AT, et al. Current imaging techniques for and imaging spectrum of prostate cancer recurrence and metastasis: a pictorial review. Radiographics . 2020;40:709–726.
Ghedini P, Bossert I, Zanoni L, et al. Liver metastases from prostate cancer at 11 C-choline PET/CT: a multicenter, retrospective analysis. Eur J Nucl Med Mol Imaging . 2018;45:751–758.
Dejust S, Messaoud L, Jallerat P, et al. Hepatic metastases from prostatic adenocarcinoma without elevated 18 F-choline activity. Clin Nucl Med . 2018;43:780–781.
Baiomy A, Martiniova L, Efstathiou E, et al. Prostate cancer liver metastases presenting as relatively photopenic lesions on 18 F-fluciclovine PET/CT. Clin Nucl Med . 2021;46:e240–e241.
Damjanovic J, Janssen JC, Prasad V, et al. 68 Ga-PSMA-PET/CT for the evaluation of liver metastases in patients with prostate cancer. Cancer Imaging . 2019;19:37.