Anxiety and behavioral changes in Japanese patients with inflammatory bowel disease due to COVID-19 pandemic: a national survey.
Anxiety
COVID-19
Inflammatory bowel disease
Questionnaire survey
Journal
Journal of gastroenterology
ISSN: 1435-5922
Titre abrégé: J Gastroenterol
Pays: Japan
ID NLM: 9430794
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
received:
23
11
2022
accepted:
26
12
2022
pubmed:
7
1
2023
medline:
14
3
2023
entrez:
6
1
2023
Statut:
ppublish
Résumé
Given the increasing health concerns for patients with inflammatory bowel disease (IBD), amidst the COVID-19 pandemic, we investigated the impact of the pandemic on the anxiety and behavioral changes in Japanese patients with IBD. We analyzed 3032 questionnaires from patients with IBD, aged 16 years or older visiting 30 hospitals and 1 clinic between March 2020 and June 2021. The primary outcome was the score of the anxiety experienced by patients with IBD during the pandemic. Participants reported a median age of 44 years; 43.3% of the patients were women. Moreover, 60.6% and 39.4% were diagnosed with ulcerative colitis and Crohn's disease, respectively, with a median disease duration of 10 years. Participants indicated an average of disease-related anxiety score of 5.1 ± 2.5 on a ten-point scale, with a tendency to increase, 1 month after the number of infected persons per population increased. The top three causes for anxiety were the risk of contracting COVID-19 during hospital visits, SARS-CoV-2 infection due to IBD, and infection by IBD medication. Factors associated with anxiety were gender (women), being a homemaker, hospital visit timings, mode of transportation (train), use of immunosuppressive drugs, and nutritional therapy. Most patients continued attending their scheduled hospital visits, taking their medications, experienced the need for a family doctor, and sought guidance and information regarding COVID-19 from primary doctors, television, and Internet news. Patients with IBD experienced moderate disease-related anxiety due to the pandemic and should be proactively informed about infectious diseases to relieve their anxiety.
Sections du résumé
BACKGROUND
Given the increasing health concerns for patients with inflammatory bowel disease (IBD), amidst the COVID-19 pandemic, we investigated the impact of the pandemic on the anxiety and behavioral changes in Japanese patients with IBD.
METHODS
We analyzed 3032 questionnaires from patients with IBD, aged 16 years or older visiting 30 hospitals and 1 clinic between March 2020 and June 2021. The primary outcome was the score of the anxiety experienced by patients with IBD during the pandemic.
RESULTS
Participants reported a median age of 44 years; 43.3% of the patients were women. Moreover, 60.6% and 39.4% were diagnosed with ulcerative colitis and Crohn's disease, respectively, with a median disease duration of 10 years. Participants indicated an average of disease-related anxiety score of 5.1 ± 2.5 on a ten-point scale, with a tendency to increase, 1 month after the number of infected persons per population increased. The top three causes for anxiety were the risk of contracting COVID-19 during hospital visits, SARS-CoV-2 infection due to IBD, and infection by IBD medication. Factors associated with anxiety were gender (women), being a homemaker, hospital visit timings, mode of transportation (train), use of immunosuppressive drugs, and nutritional therapy. Most patients continued attending their scheduled hospital visits, taking their medications, experienced the need for a family doctor, and sought guidance and information regarding COVID-19 from primary doctors, television, and Internet news.
CONCLUSIONS
Patients with IBD experienced moderate disease-related anxiety due to the pandemic and should be proactively informed about infectious diseases to relieve their anxiety.
Identifiants
pubmed: 36607399
doi: 10.1007/s00535-022-01949-6
pii: 10.1007/s00535-022-01949-6
pmc: PMC9821342
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
205-216Subventions
Organisme : Ministry of Health, Labour and Welfare
ID : 20FC1037
Organisme : Ministry of Health, Labour and Welfare
ID : JPMH21HA2011
Informations de copyright
© 2023. The Author(s).
Références
WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020. https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19-11-march-2020
Wu Z, McGoogan JM. Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323:1239–42.
doi: 10.1001/jama.2020.2648
Nakase H, Uchino M, Shinzaki S, et al. Evidence-based clinical practice guidelines for inflammatory bowel disease 2020. J Gastroenterol. 2021;56:489–526.
doi: 10.1007/s00535-021-01784-1
Kennedy NA, Hansen R, Younge L, et al. Organisational changes and challenges for inflammatory bowel disease services in the UK during the COVID-19 pandemic. Frontline Gastroenterol. 2020;11:343–50.
doi: 10.1136/flgastro-2020-101520
Danese S, Cecconi M, Spinelli A. Management of IBD during the COVID-19 outbreak: resetting clinical priorities. Nat Rev Gastroenterol Hepatol. 2020;17:253–5.
doi: 10.1038/s41575-020-0294-8
Mir N, Cheesbrough J, Troth T, et al. COVID-19-related health anxieties and impact of specific interventions in patients with inflammatory bowel disease in the UK. Frontline Gastroenterol. 2020;12:200–6.
doi: 10.1136/flgastro-2020-101633
Goodsall TM, Han S, Bryant RV. Understanding attitudes, concerns, and health behaviors of patients with inflammatory bowel disease during the coronavirus disease 2019 pandemic. J Gastroenterol Hepatol. 2021;36:1550–5.
doi: 10.1111/jgh.15299
Chen Y, Hu S, Wu H, et al. Patterns of care for inflammatory bowel disease in China during the COVID-19 pandemic. Lancet Gastroenterol Hepatol. 2020;5:632–4.
doi: 10.1016/S2468-1253(20)30131-X
Dorfman L, Nassar R, Ohana DB, et al. Pediatric inflammatory bowel disease and the effect of COVID-19 pandemic on treatment adherence and patients’ behavior. Pediatric Res. 2021;90:637–41.
doi: 10.1038/s41390-020-01312-6
Trindade IA, Ferreira NB. COVID-19 Pandemic’s Effects on Disease and Psychological Outcomes of People with Inflammatory Bowel Disease in Portugal: A Preliminary Research. Inflamm Bowel Dis. 2021;27:1224–9.
doi: 10.1093/ibd/izaa261
Grunert PC, Reuken PA, Stallhofer J, et al. Inflammatory Bowel Disease in the COVID-19 Pandemic: the Patients’ Perspective. J Crohns Colitis. 2020;14:1702–8.
doi: 10.1093/ecco-jcc/jjaa126
Iborra I, Puig M, Marín L, et al. Treatment Adherence and Clinical Outcomes of Patients with Inflammatory Bowel Disease on Biological Agents During the SARS-CoV-2 Pandemic. Dig Dis Sci. 2021;66:4191–6.
doi: 10.1007/s10620-020-06807-0
Hayes B, Apputhurai P, Mikocka-Walus A, et al. Extending the common sense model to explore the impact of the fear of COVID-19 on quality of life in an international inflammatory bowel disease cohort. J Clin Psychol Med Settings. 2022;29:678–88.
doi: 10.1007/s10880-021-09823-y
D’Amico F, Rahier JF, Leone S, et al. Views of patients with inflammatory bowel disease on the COVID-19 pandemic: a global survey. Lancet Gastroenterol Hepatol. 2020;5:631–2.
doi: 10.1016/S2468-1253(20)30151-5
Mao R, Liang J, Shen J, et al. Implications of COVID-19 for patients with pre-existing digestive diseases. Lancet Gastroenterol Hepatol. 2020;5:425–7.
doi: 10.1016/S2468-1253(20)30076-5
Bernstein CN, Ng SC, Banerjee R, et al. Worldwide management of inflammatory bowel disease during the COVID-19 pandemic: An international survey. Inflamm Bowel Dis. 2021;27:836–47.
doi: 10.1093/ibd/izaa202
Rubin DT, Feuerstein JD, Wang AY, et al. AGA clinical practice update on management of inflammatory bowel disease during the COVID-19 pandemic: Expert commentary. Gastroenterology. 2020;159:350–7.
doi: 10.1053/j.gastro.2020.04.012
Rubin DT, Abreu MT, Rai V, et al; International Organization for the Study of Inflammatory Bowel Disease. Management of patients with Crohn's disease and ulcerative colitis during the coronavirus disease-2019 pandemic: Results of an international meeting. Gastroenterology. 2020;159:6–13.
Neumann H, Emura F, Bokemeyer B, et al. Practical advice for management of inflammatory bowel diseases patients during the COVID-19 pandemic: World Endoscopy Organization Statement. Dig Endosc. 2020;32:658–62.
doi: 10.1111/den.13712
Fenollar-Cortés J, Jiménez Ó, Ruiz-García A, et al. Gender differences in psychological impact of the confinement during the COVID-19 outbreak in Spain: A longitudinal study. Front Psychol. 2021;12: 682860.
doi: 10.3389/fpsyg.2021.682860
Vesga-López O, Schneier FR, Wang S, et al. Gender differences in generalized anxiety disorder: Results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). J Clin Psychiatry. 2008;69:1606–16.
doi: 10.4088/JCP.v69n1011
Brenner EJ, Ungaro RC, Gearry RB, et al. Corticosteroids, but not TNF antagonists, are associated with adverse COVID-19 outcomes in patients with inflammatory bowel diseases: Results from an international registry. Gastroenterology. 2020;159:481–91.
doi: 10.1053/j.gastro.2020.05.032
Ungaro RC, Brenner EJ, Agrawal M, et al; Surveillance Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD) Research Group. Impact of medications on COVID-19 outcomes in inflammatory bowel disease: Analysis of over 6,000 patients from an international registry. Gastroenterology. 2022;162:316–9.
Nakase H, Matsumoto T, Matsuura M, et al. Expert opinions on the current therapeutic management of inflammatory bowel disease during the COVID-19 pandemic: Japan IBD COVID-19 taskforce, intractable diseases, the health and labor sciences research. Digestion. 2021;1024:814–22.
doi: 10.1159/000510502
Trindade IA, Ferreira NB. COVID-19 Pandemic’s effects on disease and psychological outcomes of people with inflammatory bowel dDisease in Portugal: A preliminary research. Inflamm Bowel Dis. 2021;27:1224–9.
doi: 10.1093/ibd/izaa261
Lee YJ, Kim KO, Kim MC, et al; Crohn's and Colitis Association in Daegu-Gyeongbuk (CCAiD). Perceptions and Behaviors of Patients with Inflammatory Bowel Disease during the COVID-19 Crisis. Gut Liver. 2022;16:81–91.
The Ministry of Health, Labor and Welfare of Japan IBD research group. JAPAN IBD COVID-19 Taskforce brochure for physicians and patients. http://www.ibdjapan.org