Design and quantitative evaluation of 'Aerosol Bio-Containment Device (ABCD)' for reducing aerosol exposure during infectious aerosol-generating events.


Journal

PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081

Informations de publication

Date de publication:
2023
Historique:
received: 07 12 2021
accepted: 25 07 2022
entrez: 6 1 2023
pubmed: 7 1 2023
medline: 11 1 2023
Statut: epublish

Résumé

The Coronavirus Disease 2019 (COVID-19) pandemic renewed interest in infectious aerosols and reducing risk of airborne respiratory pathogen transmission, prompting development of devices to protect healthcare workers during airway procedures. However, there are no standard methods for assessing the efficacy of particle containment with these protective devices. We designed and built an aerosol bio-containment device (ABCD) to contain and remove aerosol via an external suction system and tested the aerosol containment of the device in an environmental chamber using a novel, quantitative assessment method. The ABCD exhibited a strong ability to control aerosol exposure in experimental and computational fluid dynamic (CFD) simulated scenarios with appropriate suction use and maintenance of device seals. Using a log-risk-reduction framework, we assessed device containment efficacy and showed that, when combined with other protective equipment, the ABCD can significantly reduce airborne clinical exposure. We propose this type of quantitative analysis serves as a basis for rating efficacy of aerosol protective enclosures.

Identifiants

pubmed: 36608021
doi: 10.1371/journal.pone.0272716
pii: PONE-D-21-38216
pmc: PMC9821519
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0272716

Informations de copyright

Copyright: © 2023 Waring et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Déclaration de conflit d'intérêts

All authors declare a US pending patent application entitled, “Intubation protective tent and methods of use.” Assignee: Drexel University, 2020. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

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Auteurs

Michael S Waring (MS)

Department of Civil, Architectural and Environmental Engineering, Drexel University, Philadelphia, PA, United States of America.

L James Lo (LJ)

Department of Civil, Architectural and Environmental Engineering, Drexel University, Philadelphia, PA, United States of America.

Michael A Kohanski (MA)

Division of Rhinology, Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.

Elizabeth Kahle (E)

School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, United States of America.

Ian M Marcus (IM)

Department of Civil, Architectural and Environmental Engineering, Drexel University, Philadelphia, PA, United States of America.

Heather Smith (H)

Life Sciences Department, Riverside City College, Riverside, CA, United States of America.

Kara L Spiller (KL)

School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, United States of America.

Sharon L Walker (SL)

Department of Civil, Architectural and Environmental Engineering, Drexel University, Philadelphia, PA, United States of America.

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