Extrinsic control of the early postnatal CA1 hippocampal circuits.

Animals Mice Hippocampus / physiology Neurons / physiology Thalamus Entorhinal Cortex / physiology CA1 Region, Hippocampal / physiology
circuits development entorhinal cortex hippocampus thalamus

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
15 03 2023
Historique:
received: 03 06 2022
revised: 18 10 2022
accepted: 08 12 2022
pubmed: 8 1 2023
medline: 21 3 2023
entrez: 7 1 2023
Statut: ppublish

Résumé

The adult CA1 region of the hippocampus produces coordinated neuronal dynamics with minimal reliance on its extrinsic inputs. By contrast, neonatal CA1 is tightly linked to externally generated sensorimotor activity, but the circuit mechanisms underlying early synchronous activity in CA1 remain unclear. Here, using a combination of in vivo and ex vivo circuit mapping, calcium imaging, and electrophysiological recordings in mouse pups, we show that early dynamics in the ventro-intermediate CA1 are under the mixed influence of entorhinal (EC) and thalamic (VMT) inputs. Both VMT and EC can drive internally generated synchronous events ex vivo. However, movement-related population bursts detected in vivo are exclusively driven by the EC. These differential effects on synchrony reflect the different intrahippocampal targets of these inputs. Hence, cortical and subcortical pathways act differently on the neonatal CA1, implying distinct contributions to the development of the hippocampal microcircuit and related cognitive maps.

Identifiants

DOI: 10.1016/j.neuron.2022.12.013 PMID: 36608692
pubmed: 36608692
pii: S0896-6273(22)01086-8
doi: 10.1016/j.neuron.2022.12.013
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

888-902.e8

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Erwan Leprince (E)

Aix Marseille University, INSERM, INMED (UMR1249), Turing Centre for Living systems, Marseille, France.

Robin F Dard (RF)

Aix Marseille University, INSERM, INMED (UMR1249), Turing Centre for Living systems, Marseille, France.

Salomé Mortet (S)

Aix Marseille University, INSERM, INMED (UMR1249), Turing Centre for Living systems, Marseille, France.

Caroline Filippi (C)

Aix Marseille University, INSERM, INMED (UMR1249), Turing Centre for Living systems, Marseille, France.

Marie Giorgi-Kurz (M)

Aix Marseille University, INSERM, INMED (UMR1249), Turing Centre for Living systems, Marseille, France.

Romain Bourboulou (R)

Department of Cell and Developmental Biology, University College London, London, UK.

Pierre-Pascal Lenck-Santini (PP)

Aix Marseille University, INSERM, INMED (UMR1249), Turing Centre for Living systems, Marseille, France.

Michel A Picardo (MA)

Aix Marseille University, INSERM, INMED (UMR1249), Turing Centre for Living systems, Marseille, France.

Marco Bocchio (M)

Aix Marseille University, INSERM, INMED (UMR1249), Turing Centre for Living systems, Marseille, France; Department of Psychology, Durham University, Durham, UK.

Agnès Baude (A)

Aix Marseille University, INSERM, INMED (UMR1249), Turing Centre for Living systems, Marseille, France.

Rosa Cossart (R)

Aix Marseille University, INSERM, INMED (UMR1249), Turing Centre for Living systems, Marseille, France. Electronic address: rosa.cossart@inserm.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Extrinsic control of the early postnatal CA1...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Extrinsic control of the early postnatal CA1...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Extrinsic control of the early postnatal CA1...
questionsmedicales.fr › Cellules › Neurones › Extrinsic control of the early postnatal CA1...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Thalamus › Extrinsic control of the early postnatal CA1...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex olfactif › Cortex entorhinal › Extrinsic control of the early postnatal CA1...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Région CA1 de l'hippocampe › Extrinsic control of the early postnatal CA1...