Molecular subtypes of ALS are associated with differences in patient prognosis.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
06 01 2023
06 01 2023
Historique:
received:
26
04
2022
accepted:
06
12
2022
pubmed:
8
1
2023
medline:
11
1
2023
entrez:
7
1
2023
Statut:
epublish
Résumé
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with poorly understood clinical heterogeneity, underscored by significant differences in patient age at onset, symptom progression, therapeutic response, disease duration, and comorbidity presentation. We perform a patient stratification analysis to better understand the variability in ALS pathology, utilizing postmortem frontal and motor cortex transcriptomes derived from 208 patients. Building on the emerging role of transposable element (TE) expression in ALS, we consider locus-specific TEs as distinct molecular features during stratification. Here, we identify three unique molecular subtypes in this ALS cohort, with significant differences in patient survival. These results suggest independent disease mechanisms drive some of the clinical heterogeneity in ALS.
Identifiants
pubmed: 36609402
doi: 10.1038/s41467-022-35494-w
pii: 10.1038/s41467-022-35494-w
pmc: PMC9822908
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
95Informations de copyright
© 2023. The Author(s).
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