Previously independent patients with mild-symptomatic COVID-19 are at high risk of developing cognitive impairment but not depression or anxiety.
COVID-19
Cognitive function
MoCA
SARS-CoV-2
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
01 03 2023
01 03 2023
Historique:
received:
29
11
2021
revised:
20
08
2022
accepted:
23
12
2022
pubmed:
8
1
2023
medline:
24
1
2023
entrez:
7
1
2023
Statut:
ppublish
Résumé
The aim of the study was to explore the cognitive functions of a large sample of hospitalised subjects with mild symptomatic Coronavirus Disease (COVID-19) who were previously independent at home and without neurological diseases. Patients admitted in a COVID-19 Unit for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection between November 2020 and March 2021 were recruited. Inclusion criteria were: being independent at home before the infection, radiologically confirmed COVID-19 pneumonia, positive reverse transcriptase-polymerase chain reaction nasopharyngeal swab and no oxygen supplementation at the time of evaluation. cognitive impairment or neurological diseases previous to the infection, delirium episodes, and history of any mechanical ventilation use. They were evaluated with Montreal Cognitive Assessment (MoCA), Hamilton Depression Rating Scale (HAM-D) and Hamilton Anxiety Rating Scale (HAM-A). Out of 522 subjects admitted in the COVID-19 Unit, 90 were enrolled [mean age = 68.32(11.99); 46M/44F]. An impaired MoCA (cut-off < 23) was found in 60 subjects (66.66 %). Pathological scores were obtained by 36.7 % of the subjects with <65 years and 78.3 % of those older than 65 years. A high prevalence of executive function and memory impairment was detected. The results underline a high rate of cognitive impairment in previously independent mild COVID-19 patients. This might represent a potential threat for the everyday independence of these patients due to the consequences on everyday life activities and work following discharge from hospital. These subjects should, therefore, be monitored in order to allow a better understanding of the progression and consequences of the so-called "Long COVID".
Identifiants
pubmed: 36610599
pii: S0165-0327(22)01461-6
doi: 10.1016/j.jad.2022.12.100
pmc: PMC9812466
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
645-651Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest The authors declare no conflict of interest relevant to this paper.
Références
Neurol Sci. 2015 Feb;36(2):209-14
pubmed: 25139107
Brain. 2020 Oct 1;143(10):3104-3120
pubmed: 32637987
Occup Med (Lond). 2015 Oct;65(7):601
pubmed: 26370845
Int J Geriatr Psychiatry. 2018 Feb;33(2):379-388
pubmed: 28731508
J Neurol. 2021 Feb;268(2):392-402
pubmed: 32691236
Brain. 2021 May 7;144(4):1263-1276
pubmed: 33822001
J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
pubmed: 14399272
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
Eur Neuropsychopharmacol. 2021 May;46:39-48
pubmed: 33823427
Nat Med. 2020 Jul;26(7):1017-1032
pubmed: 32651579
Nat Med. 2021 Apr;27(4):601-615
pubmed: 33753937
Stroke. 2011 Jul;42(7):2077-9
pubmed: 21527755
Neurol Sci. 2015 Apr;36(4):585-91
pubmed: 25380622
Md State Med J. 1965 Feb;14:61-5
pubmed: 14258950
Neuropsychiatr Dis Treat. 2020 Nov 06;16:2681-2687
pubmed: 33192067
Brain Commun. 2020 May 28;2(2):fcaa069
pubmed: 33074266
Int J Neurol Neurother. 2015 Sep 30;2(3):1-8
pubmed: 26658924
Ann Phys Rehabil Med. 2020 Nov;63(6):554-556
pubmed: 32315802
J Psychiatr Res. 2021 Dec;144:129-137
pubmed: 34619491
Circ Res. 2019 Mar 29;124(7):1025-1044
pubmed: 30920929
Clin Infect Dis. 2021 Aug 2;73(3):e826-e829
pubmed: 33624010