In vivo detection of bile duct pre-cancer with endoscopic light scattering spectroscopy.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
07 01 2023
07 01 2023
Historique:
received:
23
02
2021
accepted:
23
12
2022
pubmed:
8
1
2023
medline:
11
1
2023
entrez:
7
1
2023
Statut:
epublish
Résumé
Bile duct cancer is the second most common primary liver cancer, with most diagnoses occurring in the advanced stages. This leads to a poor survival rate, which means a technique capable of reliably detecting pre-cancer in the bile duct is urgently required. Unfortunately, radiological imaging lacks adequate accuracy for distinguishing dysplastic and benign biliary ducts, while endoscopic techniques, which can directly assess the bile duct lining, often suffer from insufficient sampling. Here, we report an endoscopic optical light scattering technique for clinical evaluation of the malignant potential of the bile duct. This technique employs an ultraminiature spatial gating fiber optic probe compatible with cholangioscopes and endoscopic retrograde cholangiopancreatography (ERCP) catheters. The probe allowed us to investigate the internal cellular composition of the bile duct epithelium with light scattering spectroscopy (LSS) and phenotypic properties of the underlying connective tissue with diffuse reflectance spectroscopy (DRS). In a pilot in vivo double-blind prospective study involving 29 patients undergoing routine ERCP procedures, the technique detected malignant transformation with 97% accuracy, showing that biliary duct pre-cancer can be reliably identified in vivo non-invasively.
Identifiants
pubmed: 36611024
doi: 10.1038/s41467-022-35780-7
pii: 10.1038/s41467-022-35780-7
pmc: PMC9825389
doi:
Banques de données
figshare
['10.6084/m9.figshare.21552576']
Types de publication
Randomized Controlled Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
109Subventions
Organisme : NCI NIH HHS
ID : R01 CA205431
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA218382
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB003472
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB025173
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA228029
Pays : United States
Informations de copyright
© 2023. The Author(s).
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