A Race-Specific, DNA Methylation Analysis of Aging in Normal Rectum: Implications for the Biology of Aging and Its Relationship to Rectal Cancer.
African American
DNA methylation
aging
colorectal cancer
epigenetic aging
racial disparities
rectum
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
22 Dec 2022
22 Dec 2022
Historique:
received:
22
10
2022
revised:
01
12
2022
accepted:
19
12
2022
entrez:
8
1
2023
pubmed:
9
1
2023
medline:
9
1
2023
Statut:
epublish
Résumé
Approximately 90% of colorectal cancer (CRC) develop over the age of 50, highlighting the important role of aging in CRC risk. African Americans (AAs) shoulder a greater CRC burden than European Americans (EA) and are more likely to develop CRC at a younger age. The effects of aging in AA and EA normal rectal tissue have yet to be defined. Here, we performed epigenome-wide DNA methylation analysis in the first, large-scale biracial cohort of normal rectum (
Identifiants
pubmed: 36612042
pii: cancers15010045
doi: 10.3390/cancers15010045
pmc: PMC9817986
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : P20 CA233216
Pays : United States
Organisme : NCI NIH HHS
ID : CA143237
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA150964
Pays : United States
Organisme : University of Virginia Cancer Center
ID : P30CA044579
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