Integrative Clinical and DNA Methylation Analyses in a Population-Based Cohort Identifies

LINE1 epigenetics immune contexture oncogene signalling stage II colon cancer biomarkers transforming growth factor beta (TGFβ)

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
27 Dec 2022
Historique:
received: 28 09 2022
accepted: 20 12 2022
entrez: 8 1 2023
pubmed: 9 1 2023
medline: 9 1 2023
Statut: epublish

Résumé

Stage II colon cancer (CC), although diagnosed early, accounts for 16% of CC deaths. Predictors of recurrence risk could mitigate this but are currently lacking. By using a DNA methylation-based clinical screening in real-world (

Identifiants

pubmed: 36612154
pii: cancers15010158
doi: 10.3390/cancers15010158
pmc: PMC9817957
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : French National Cancer Institute
ID : PHRC11-254

Références

J Pathol. 2018 Nov;246(3):289-299
pubmed: 30047135
Mol Cancer Ther. 2021 Jan;20(1):96-108
pubmed: 33037135
Nat Rev Clin Oncol. 2017 Apr;14(4):235-246
pubmed: 27922044
Dev Cell. 2012 Feb 14;22(2):268-78
pubmed: 22340494
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Br J Cancer. 2020 Aug;123(3):410-417
pubmed: 32435058
J Clin Oncol. 2015 Dec 10;33(35):4176-87
pubmed: 26527776
Br J Surg. 2006 Sep;93(9):1115-22
pubmed: 16804870
Int J Mol Sci. 2019 Jul 09;20(13):
pubmed: 31324051
Immunity. 2018 Apr 17;48(4):812-830.e14
pubmed: 29628290
Cell Mol Life Sci. 2018 Nov;75(21):4021-4040
pubmed: 29916093
Nat Cancer. 2021 Aug;2(8):794-802
pubmed: 35118423
Cancer Cell. 2022 Feb 14;40(2):136-152.e12
pubmed: 35051357
Clin Colorectal Cancer. 2016 Jun;15(2):164-9
pubmed: 26702772
Front Oncol. 2021 Jun 15;11:685515
pubmed: 34211853
Nat Med. 2015 Nov;21(11):1350-6
pubmed: 26457759
Eur J Cancer Prev. 2006 Aug;15(4):295-300
pubmed: 16835501
Cancer. 1997 Nov 1;80(9):1803-4
pubmed: 9351551
Ann Oncol. 2020 Oct;31(10):1291-1305
pubmed: 32702383
Biomedicines. 2022 Dec 01;10(12):
pubmed: 36551854
Cell Syst. 2015 Dec 23;1(6):417-425
pubmed: 26771021
Lancet. 2007 Dec 15;370(9604):2020-9
pubmed: 18083404
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Adv Sci (Weinh). 2020 Feb 11;7(7):1902880
pubmed: 32274301
Dig Liver Dis. 2020 Jul;52(7):730-733
pubmed: 32482534
Front Oncol. 2021 May 31;11:660696
pubmed: 34136393
Nat Cancer. 2020 Jun;1(6):620-634
pubmed: 35121975
Dis Colon Rectum. 2013 Oct;56(10):1118-24
pubmed: 24022528
Gastroenterology. 2007 Feb;132(2):645-53
pubmed: 17258723
Clin Cancer Res. 2018 Oct 1;24(19):4745-4753
pubmed: 29921730
Nat Rev Gastroenterol Hepatol. 2020 Feb;17(2):111-130
pubmed: 31900466
CA Cancer J Clin. 2020 May;70(3):145-164
pubmed: 32133645
Cell Rep. 2022 Jul 12;40(2):111051
pubmed: 35830810
BMC Cancer. 2012 Jan 13;12:12
pubmed: 22243995
Dig Liver Dis. 2015 Jul;47(7):529-31
pubmed: 25933809

Auteurs

Benjamin Tournier (B)

Faculty of Health Sciences, University of Burgundy, 21000 Dijon, France.
Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1231, 21000 Dijon, France.
Department of Pathology, Dijon University Hospital, 21000 Dijon, France.

Romain Aucagne (R)

Faculty of Health Sciences, University of Burgundy, 21000 Dijon, France.
Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1231, 21000 Dijon, France.
Unit for Innovation in Genetics and Epigenetics in Oncology (IGEO) and CRIGEN (Crispr Functional Genomics), Dijon University Hospital, 21000 Dijon, France.
Genetics and Immunology Medical Institute (GIMI), 21000 Dijon, France.

Caroline Truntzer (C)

Faculty of Health Sciences, University of Burgundy, 21000 Dijon, France.
Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1231, 21000 Dijon, France.
Unit for Innovation in Genetics and Epigenetics in Oncology (IGEO) and CRIGEN (Crispr Functional Genomics), Dijon University Hospital, 21000 Dijon, France.
Centre Georges-François Leclerc (CGFL), 21000 Dijon, France.

Cyril Fournier (C)

Faculty of Health Sciences, University of Burgundy, 21000 Dijon, France.
Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1231, 21000 Dijon, France.
Unit for Innovation in Genetics and Epigenetics in Oncology (IGEO) and CRIGEN (Crispr Functional Genomics), Dijon University Hospital, 21000 Dijon, France.
Genetics and Immunology Medical Institute (GIMI), 21000 Dijon, France.

François Ghiringhelli (F)

Faculty of Health Sciences, University of Burgundy, 21000 Dijon, France.
Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1231, 21000 Dijon, France.
Unit for Innovation in Genetics and Epigenetics in Oncology (IGEO) and CRIGEN (Crispr Functional Genomics), Dijon University Hospital, 21000 Dijon, France.
Genetics and Immunology Medical Institute (GIMI), 21000 Dijon, France.
Centre Georges-François Leclerc (CGFL), 21000 Dijon, France.

Caroline Chapusot (C)

Department of Pathology, Dijon University Hospital, 21000 Dijon, France.

Laurent Martin (L)

Faculty of Health Sciences, University of Burgundy, 21000 Dijon, France.
Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1231, 21000 Dijon, France.
Department of Pathology, Dijon University Hospital, 21000 Dijon, France.

Anne Marie Bouvier (AM)

Faculty of Health Sciences, University of Burgundy, 21000 Dijon, France.
Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1231, 21000 Dijon, France.

Sylvain Manfredi (S)

Faculty of Health Sciences, University of Burgundy, 21000 Dijon, France.
Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1231, 21000 Dijon, France.
Department of Hepato-Gastroenterology and Digestive Oncology, Dijon University Hospital, 21000 Dijon, France.

Valérie Jooste (V)

Faculty of Health Sciences, University of Burgundy, 21000 Dijon, France.
Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1231, 21000 Dijon, France.
Department of Hepato-Gastroenterology and Digestive Oncology, Dijon University Hospital, 21000 Dijon, France.

Mary B Callanan (MB)

Faculty of Health Sciences, University of Burgundy, 21000 Dijon, France.
Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1231, 21000 Dijon, France.
Unit for Innovation in Genetics and Epigenetics in Oncology (IGEO) and CRIGEN (Crispr Functional Genomics), Dijon University Hospital, 21000 Dijon, France.
Genetics and Immunology Medical Institute (GIMI), 21000 Dijon, France.

Côme Lepage (C)

Faculty of Health Sciences, University of Burgundy, 21000 Dijon, France.
Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1231, 21000 Dijon, France.
Department of Hepato-Gastroenterology and Digestive Oncology, Dijon University Hospital, 21000 Dijon, France.

Classifications MeSH