A Multidisciplinary Approach Establishes a Link between Transglutaminase 2 and the Kv10.1 Voltage-Dependent K
AA9
K+ channel
KCNH1
Kv10.1
MDA-MB-231 cells
breast cancer
patch-clamp
transglutaminase 2
transglutaminase inhibitors
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
28 Dec 2022
28 Dec 2022
Historique:
received:
21
10
2022
revised:
15
12
2022
accepted:
24
12
2022
entrez:
8
1
2023
pubmed:
9
1
2023
medline:
9
1
2023
Statut:
epublish
Résumé
Since the multifunctionality of transglutaminase 2 (TG2) includes extra- and intracellular functions, we investigated the effects of intracellular administration of TG2 inhibitors in three breast cancer cell lines, MDA-MB-231, MDA-MB-436 and MDA-MB-468, which are representative of different triple-negative phenotypes, using a patch-clamp technique. The first cell line has a highly voltage-dependent a membrane current, which is low in the second and almost absent in the third one. While applying a voltage protocol to responsive single cells, injection of TG2 inhibitors triggered a significant decrease of the current in MDA-MB-231 that we attributed to voltage-dependent K
Identifiants
pubmed: 36612174
pii: cancers15010178
doi: 10.3390/cancers15010178
pmc: PMC9818547
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : N. Bianchi by FAR2021
ID : FAR2191074
Organisme : N. Bianchi by FIR2021
ID : FIR2191318
Organisme : S. Volinia by FAR2021
Organisme : V. Bertagnolo by FAR2021
Organisme : F. Brugnoli by FIRD2022
Organisme : R. Canella by FAR2020
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