Hepcidin as a Diagnostic Biomarker in Anaemic Lung Cancer Patients.

anaemia of chronic disease anaemia of inflammation biomarkers hepcidin iron deficiency anaemia lung cancer non-small cell lung carcinoma overall survival quality of life

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
30 Dec 2022
Historique:
received: 17 11 2022
revised: 22 12 2022
accepted: 27 12 2022
entrez: 8 1 2023
pubmed: 9 1 2023
medline: 9 1 2023
Statut: epublish

Résumé

We aim to describe the characteristics of hepcidin, IL-6, and TNF-α levels in anaemia of lung cancer patients with operative tumour as well as to investigate the potential diagnostic capabilities of hepcidin in combination with IL-6, TNF-α, and acute phase proteins. We present a retrospective study of 112 lung cancer patients (41 women and 71 men) who were surgically treated at the Lower Silesian Centre for Lung Diseases in Wroclaw, Poland. Serum blood samples were collected from all these patients prior to any surgical treatment and used to determine hepcidin, IL-6, TNF-α, SAA

Identifiants

pubmed: 36612220
pii: cancers15010224
doi: 10.3390/cancers15010224
pmc: PMC9818260
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : IT Simple system of Wroclaw Medical University
ID : SUBZ.D010.22.039

Références

Mediators Inflamm. 2009;2009:405016
pubmed: 20204172
Blood Cells Mol Dis. 2010 Oct 15;45(3):238-45
pubmed: 20800515
Cancers (Basel). 2022 Oct 08;14(19):
pubmed: 36230859
Nat Rev Cardiol. 2018 Sep;15(9):505-522
pubmed: 30065258
Carcinogenesis. 2007 Mar;28(3):507-18
pubmed: 17183062
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Blood. 2006 Nov 1;108(9):3204-9
pubmed: 16835372
Braz J Med Biol Res. 2019;52(9):e8392
pubmed: 31411315
Cancers (Basel). 2022 Oct 27;14(21):
pubmed: 36358713
Ann N Y Acad Sci. 2000 Jun;908:244-54
pubmed: 10911963
Oncology. 2005;68 Suppl 1:12-21
pubmed: 15855812
Exp Mol Med. 2018 Feb 2;50(2):e436
pubmed: 29391539
Cancer Manag Res. 2019 Jan 21;11:943-953
pubmed: 30718965
Biomolecules. 2021 Aug 13;11(8):
pubmed: 34439874
Am J Med. 2004 Apr 5;116 Suppl 7A:11S-26S
pubmed: 15050883
Int J Mol Sci. 2020 Jun 27;21(13):
pubmed: 32604993
Oncologist. 2009;14 Suppl 1:43-56
pubmed: 19762516
Eur J Cancer. 2004 Oct;40(15):2293-306
pubmed: 15454256
Clin Lung Cancer. 2003 Sep;5(2):90-7
pubmed: 14596691
Oncologist. 2002;7(6):492-508
pubmed: 12490737
J Natl Cancer Inst. 1999 Oct 6;91(19):1616-34
pubmed: 10511589
Autoimmunity. 2018 Jun;51(4):191-198
pubmed: 29869537
Ann Oncol. 2018 Oct 1;29(Suppl 4):iv96-iv110
pubmed: 29471514
Clin Geriatr Med. 2017 Nov;33(4):459-471
pubmed: 28991644
J Clin Oncol. 1991 Sep;9(9):1618-26
pubmed: 1651993
Ann Oncol. 2010 Oct;21 Suppl 7:vii167-72
pubmed: 20943610
Blood. 2005 Jul 1;106(1):362-7
pubmed: 15774616
PLoS One. 2014 Mar 28;9(3):e93283
pubmed: 24681760
Cancer Res. 1987 Jun 1;47(11):2986-9
pubmed: 3567916
Oncology. 2005;68 Suppl 1:3-11
pubmed: 15855811
J Thorac Dis. 2020 May;12(5):1895-1902
pubmed: 32642093

Auteurs

Katarzyna Wadowska (K)

Department of Medical Laboratory Diagnostics, Division of Clinical Chemistry and Laboratory Haematology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.

Piotr Błasiak (P)

Department and Clinic of Thoracic Surgery, Faculty of Medicine, Wroclaw Medical University, Grabiszyńska 105, 53-439 Wroclaw, Poland.
Lower Silesian Centre of Oncology, Pulmonology and Haematology, Lower Silesian Thoracic Surgery Centre, Grabiszyńska 105, 53-439 Wroclaw, Poland.

Adam Rzechonek (A)

Department and Clinic of Thoracic Surgery, Faculty of Medicine, Wroclaw Medical University, Grabiszyńska 105, 53-439 Wroclaw, Poland.
Lower Silesian Centre of Oncology, Pulmonology and Haematology, Lower Silesian Thoracic Surgery Centre, Grabiszyńska 105, 53-439 Wroclaw, Poland.

Iwona Bil-Lula (I)

Department of Medical Laboratory Diagnostics, Division of Clinical Chemistry and Laboratory Haematology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.

Mariola Śliwińska-Mossoń (M)

Department of Medical Laboratory Diagnostics, Division of Clinical Chemistry and Laboratory Haematology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.

Classifications MeSH