Increasing Dosage of Leucovorin Results in Pharmacokinetic and Gene Expression Differences When Administered as Two-Hour Infusion or Bolus Injection to Patients with Colon Cancer.
LC-MS/MS
bolus injection
colon cancer
gene expression
leucovorin
methylenetetrahydrofolate
pharmacokinetics
two-hour infusion
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
30 Dec 2022
30 Dec 2022
Historique:
received:
01
12
2022
revised:
26
12
2022
accepted:
28
12
2022
entrez:
8
1
2023
pubmed:
9
1
2023
medline:
9
1
2023
Statut:
epublish
Résumé
The combination of 5-fluorouracil (5-FU) and leucovorin (LV) forms the chemotherapy backbone for patients with colorectal cancer. However, the LV administration is often standardized and not based on robust scientific data. To address these issues, a randomized pharmacokinetics study was performed in patients with colon cancer. Thirty patients were enrolled, receiving 60, 200 or 500 mg/m
Identifiants
pubmed: 36612253
pii: cancers15010258
doi: 10.3390/cancers15010258
pmc: PMC9818718
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Swedish Cancer Society
ID : CAN 2015/499, CAN 2018/620, CAN 201025PjF
Organisme : King Gustav V Jubilee Clinic Foundation for Cancer Research
ID : 2016:70
Organisme : The Swedish State under the LUA/ALF agreement
ID : ALFGBG-426941, ALFGBG-586631, ALFGBG-723361, ALFGBG-788901, ALFGBG-966007
Organisme : The Swedish Society of Medicine
ID : SLS-689001
Organisme : The Assar Gabrielssons Foundation
ID : FB17-82
Organisme : The Inga-Britt and Arne Lundberg Foundation
ID : 335/07
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