Impact of Nanoparticles on Male Fertility: What Do We Really Know? A Systematic Review.
blood–testis barrier
nanosized objects
reprotoxicity
testicular biodistribution
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Dec 2022
29 Dec 2022
Historique:
received:
06
12
2022
revised:
21
12
2022
accepted:
23
12
2022
entrez:
8
1
2023
pubmed:
9
1
2023
medline:
11
1
2023
Statut:
epublish
Résumé
The real impact of nanoparticles on male fertility is evaluated after a careful analysis of the available literature. The first part reviews animal models to understand the testicular biodistribution and biopersistence of nanoparticles, while the second part evaluates their in vitro and in vivo biotoxicity. Our main findings suggest that nanoparticles are generally able to reach the testicle in small quantities where they persist for several months, regardless of the route of exposure. However, there is not enough evidence that they can cross the blood-testis barrier. Of note, the majority of nanoparticles have low direct toxicity to the testis, but there are indications that some might act as endocrine disruptors. Overall, the impact on spermatogenesis in adults is generally weak and reversible, but exceptions exist and merit increased attention. Finally, we comment on several methodological or analytical biases which have led some studies to exaggerate the reprotoxicity of nanoparticles. In the future, rigorous clinical studies in tandem with mechanistic studies are needed to elucidate the real risk posed by nanoparticles on male fertility.
Identifiants
pubmed: 36614018
pii: ijms24010576
doi: 10.3390/ijms24010576
pmc: PMC9820737
pii:
doi:
Types de publication
Systematic Review
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Biol Trace Elem Res. 2017 Jan;175(1):161-168
pubmed: 27239677
Analyst. 2018 Jan 15;143(2):475-486
pubmed: 29230439
J Biomed Nanotechnol. 2018 Dec 1;14(12):2124-2134
pubmed: 30305219
Lancet. 1977 Dec 17;2(8051):1259-61
pubmed: 73955
Biomed Microdevices. 2015 Aug;17(4):66
pubmed: 26044201
Nanomedicine (Lond). 2012 Apr;7(4):579-96
pubmed: 22471721
Bratisl Lek Listy. 2016;117(11):659-664
pubmed: 28125892
Nanotoxicology. 2020 Apr;14(3):326-340
pubmed: 31909642
J Nanobiotechnology. 2015 Nov 17;13:83
pubmed: 26577398
Hum Reprod. 2001 May;16(5):1012-9
pubmed: 11331653
Nanoscale. 2014 Jul 21;6(14):8265-73
pubmed: 24931221
Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:52-9
pubmed: 27612688
Toxicol Pathol. 1997 Mar-Apr;25(2):119-31
pubmed: 9125770
JBRA Assist Reprod. 2019 Oct 14;23(4):344-351
pubmed: 31091065
Front Pharmacol. 2017 Sep 05;8:606
pubmed: 28928662
Arch Razi Inst. 2018 Jun;73(2):121-129
pubmed: 30242803
Inhal Toxicol. 2012 Aug;24(9):599-608
pubmed: 22861003
Sci Total Environ. 2019 Apr 10;660:1264-1273
pubmed: 30743921
Environ Res. 2017 Jan;152:503-513
pubmed: 27776739
Biomed Environ Sci. 2018 Mar;31(3):197-207
pubmed: 29673442
Int J Nanomedicine. 2013;8:2409-19
pubmed: 23861586
Regul Toxicol Pharmacol. 2017 Nov;90:222-230
pubmed: 28923501
Environ Sci Pollut Res Int. 2019 Jun;26(16):15816-15827
pubmed: 30953321
Environ Health Perspect. 1997 Nov;105(11):1228-32
pubmed: 9370524
J Hazard Mater. 2015 Dec 30;300:718-728
pubmed: 26296075
Reprod Toxicol. 2015 Aug 15;56:147-54
pubmed: 25817409
Arch Androl. 2003 Mar-Apr;49(2):139-44
pubmed: 12623750
J Mater Sci Mater Med. 2014 Mar;25(3):769-76
pubmed: 24276671
Int J Mol Sci. 2014 Sep 10;15(9):15981-93
pubmed: 25210847
PLoS Med. 2009 Jul 21;6(7):e1000100
pubmed: 19621070
Environ Pollut. 2007 Mar;146(1):9-18
pubmed: 16996184
Environ Sci Technol. 2019 Nov 19;53(22):13408-13416
pubmed: 31362495
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1846-1858
pubmed: 31066299
Nanomedicine (Lond). 2015;10(18):2931-52
pubmed: 26370561
Int J Nanomedicine. 2018 Sep 28;13:5909-5924
pubmed: 30319256
Bratisl Lek Listy. 2015;116(10):616-20
pubmed: 26531873
Iran J Reprod Med. 2013 May;11(5):423-30
pubmed: 24639775
J Toxicol Environ Health A. 2016;79(21):984-997
pubmed: 27558875
Int J Fertil Steril. 2018 Jun;12(3):249-256
pubmed: 29935072
J Androl. 2001 Jan-Feb;22(1):40-4
pubmed: 11191086
J Hazard Mater. 2013 Aug 15;258-259:133-43
pubmed: 23721730
Food Chem Toxicol. 2015 Oct;84:154-60
pubmed: 26316185
Life Sci. 2018 Oct 15;211:81-90
pubmed: 30189219
J Appl Toxicol. 2015 Jun;35(6):573-80
pubmed: 25348882
Toxicol Ind Health. 2014 Jul;30(6):520-33
pubmed: 23064765
Curr Pharm Des. 2013;19(37):6691-7
pubmed: 23621535
Toxicol Res (Camb). 2017 Nov 23;7(1):102-116
pubmed: 30090567
J Nanosci Nanotechnol. 2016 Mar;16(3):2378-83
pubmed: 27455644
Environ Sci Pollut Res Int. 2019 Sep;26(25):25814-25824
pubmed: 31270769
AMB Express. 2019 Mar 19;9(1):38
pubmed: 30888557
J Reprod Med. 2017 May-Jun;62(5-6):317-23
pubmed: 30027728
Acta Naturae. 2009 Oct;1(3):99-101
pubmed: 22649621
Oncotarget. 2016 Jun 28;7(26):39270-39278
pubmed: 27248475
Sci Rep. 2019 Oct 7;9(1):14373
pubmed: 31591413
Toxicol Ind Health. 2018 Aug;34(8):571-588
pubmed: 29768980
Toxicol Appl Pharmacol. 2017 Feb 15;317:12-24
pubmed: 28077287
Andrologia. 2018 Apr;50(3):
pubmed: 29164652
Nanotechnology. 2019 Nov 8;30(45):455101
pubmed: 31362276
Toxicol Appl Pharmacol. 2016 Dec 15;313:35-46
pubmed: 27746313
J Biomed Mater Res A. 2017 Jan;105(1):198-208
pubmed: 27643721
Toxicol Res (Camb). 2021 Aug 09;10(4):937-946
pubmed: 34484685
Toxicol Lett. 2009 Dec 15;191(2-3):103-8
pubmed: 19699283
Environ Toxicol Pharmacol. 2019 Aug;70:103194
pubmed: 31255771
Int J Nanomedicine. 2015 Feb 16;10:1335-57
pubmed: 25733828
Toxicol Sci. 2009 Apr;108(2):452-61
pubmed: 19033393
Small. 2013 May 27;9(9-10):1557-72
pubmed: 23097249
J Agric Food Chem. 2016 Jan 13;64(1):346-55
pubmed: 26720763
Toxicol Lett. 2012 Nov 15;214(3):251-8
pubmed: 22982066
Part Fibre Toxicol. 2020 Jan 10;17(1):2
pubmed: 31924220
Fertil Steril. 2009 Jan;91(1):e7-8
pubmed: 18054925
J Agric Food Chem. 2015 Aug 12;63(31):7084-92
pubmed: 26145168
Nanotoxicology. 2013 Sep;7(6):1120-30
pubmed: 22770226
Nanomedicine (Lond). 2019 Feb;14(3):275-299
pubmed: 30657418
Part Fibre Toxicol. 2014 Sep 12;11:47
pubmed: 25209749
Toxicol Sci. 2005 Dec;88(2):412-9
pubmed: 16014736
Int J Androl. 1995 Aug;18(4):169-84
pubmed: 7591190
Nanotoxicology. 2014 May;8(3):233-78
pubmed: 23379603
J Biomed Nanotechnol. 2017 Apr;13(4):409-16
pubmed: 29384604
Bull Exp Biol Med. 2018 Dec;166(2):279-282
pubmed: 30488201
Pathol Res Pract. 2017 Jan;213(1):13-22
pubmed: 27916297
Reprod Domest Anim. 2012 Aug;47 Suppl 4:359-68
pubmed: 22827393
Asian J Androl. 2015 Mar-Apr;17(2):261-8
pubmed: 25370207
Mol Reprod Dev. 2019 Oct;86(10):1369-1377
pubmed: 30803093
J Toxicol Environ Health A. 2015;78(4):226-43
pubmed: 25674826
Biomaterials. 2008 Apr;29(12):1912-9
pubmed: 18242692
EPMA J. 2015 Jun 10;6(1):12
pubmed: 26097523
Andrologia. 2017 Nov;49(9):
pubmed: 28000929
Adv Clin Exp Med. 2019 Mar;28(3):299-305
pubmed: 30170485
Int J Nanomedicine. 2015 Oct 05;10:6243-56
pubmed: 26491295
J Mol Histol. 2017 Feb;48(1):9-27
pubmed: 27803997
Environ Sci Pollut Res Int. 2015 Jan;22(2):1127-32
pubmed: 25113834
Nanotoxicology. 2015 Feb;9(1):92-105
pubmed: 24621344
N Engl J Med. 1995 Feb 2;332(5):281-5
pubmed: 7816062
PLoS One. 2014 Apr 30;9(4):e95456
pubmed: 24787744
Environ Toxicol Pharmacol. 2017 Jun;52:193-199
pubmed: 28433807
Nanotoxicology. 2015 Feb;9(1):64-70
pubmed: 24533579
J Nanobiotechnology. 2019 Mar 21;17(1):41
pubmed: 30894193
Int J Reprod Biomed. 2016 Oct;14(10):637-642
pubmed: 27921087
Biochem Biophys Res Commun. 2012 Apr 6;420(2):297-301
pubmed: 22417826
J Appl Toxicol. 2012 Nov;32(11):900-12
pubmed: 22760929
Toxicol Res (Camb). 2017 Jan 4;6(2):115-133
pubmed: 30090482
Biomaterials. 2016 Jul;96:24-32
pubmed: 27135714
Mutat Res. 2011 Nov 27;726(1):8-14
pubmed: 21871579
Nanotoxicology. 2016;10(1):111-7
pubmed: 26001187
Int J Vet Sci Med. 2018 Feb 23;6(1):16-21
pubmed: 30255073
Biotech Histochem. 2018;93(2):118-132
pubmed: 29430971
Toxicol Sci. 2006 Jan;89(1):338-47
pubmed: 16237191
J Biomed Mater Res A. 2017 May;105(5):1374-1382
pubmed: 28188686
Chem Res Toxicol. 2019 Jun 17;32(6):986-994
pubmed: 30931558
Nat Nanotechnol. 2012 May 20;7(7):453-8
pubmed: 22609691
Chem Res Toxicol. 2019 Aug 19;32(8):1491-1503
pubmed: 31251591
Int J Mol Sci. 2014 Nov 17;15(11):21253-69
pubmed: 25407529
Toxicol Appl Pharmacol. 2017 Nov 1;334:129-141
pubmed: 28844848
J Assist Reprod Genet. 2013 Sep;30(9):1203-9
pubmed: 23949131
Reprod Toxicol. 2019 Dec;90:134-140
pubmed: 31449912
BMJ. 1996 Feb 24;312(7029):471-2
pubmed: 8597677
J Biochem Mol Toxicol. 2016 Oct;30(10):489-496
pubmed: 27111109
Inhal Toxicol. 2012 Jul;24(8):459-67
pubmed: 22712718
Chemosphere. 2019 Mar;218:259-265
pubmed: 30472609
Curr Opin Biotechnol. 2013 Aug;24(4):724-34
pubmed: 23768801
J Hazard Mater. 2020 Feb 15;384:121361
pubmed: 31606252
J Occup Health. 2008;50(1):1-6
pubmed: 18285638
Int J Nanomedicine. 2018 Dec 11;13:8487-8506
pubmed: 30587973
Arch Toxicol. 2018 Apr;92(4):1393-1405
pubmed: 29450565
Int J Androl. 2012 Jun;35(3):467-74
pubmed: 22150270
J Urol. 2015 Oct;194(4):1155-61
pubmed: 25796115
J Nanosci Nanotechnol. 2018 Apr 1;18(4):2394-2404
pubmed: 29442908
Syst Biol Reprod Med. 2014 Jun;60(3):143-50
pubmed: 24547726
Nanotoxicology. 2019 Dec;13(10):1310-1323
pubmed: 31441350
Andrologia. 2013 Dec;45(6):392-6
pubmed: 23116262
Environ Toxicol. 2017 Feb;32(2):609-618
pubmed: 26996539
Toxicol Sci. 2010 Jul;116(1):286-96
pubmed: 20360146
Arch Toxicol. 2013 Nov;87(11):1883-1900
pubmed: 24068037
J Nanobiotechnology. 2014 Oct 14;12:42
pubmed: 25311086
Environ Toxicol. 2016 May;31(5):543-51
pubmed: 25410135
J Orthop Sci. 2013 Nov;18(6):1020-6
pubmed: 24085379
Iran J Reprod Med. 2014 Feb;12(2):139-44
pubmed: 24799872
Hum Reprod Update. 2017 Nov 1;23(6):646-659
pubmed: 28981654
Biochem Biophys Res Commun. 2017 Apr 29;486(2):595-600
pubmed: 28336439
Environ Toxicol Pharmacol. 2010 Sep;30(2):162-8
pubmed: 21787647
Toxicol Sci. 2011 Mar;120 Suppl 1:S109-29
pubmed: 21177774
Int J Hyperthermia. 2018 Jun;34(4):415-422
pubmed: 28605996
Basic Clin Pharmacol Toxicol. 2017 Sep;121(3):202-210
pubmed: 28371123
J Assist Reprod Genet. 2014 May;31(5):561-8
pubmed: 24515782
Bull Exp Biol Med. 2019 Mar;166(5):680-685
pubmed: 30903502
Toxicol Sci. 2012 Jun;127(2):463-73
pubmed: 22430073
Environ Pollut. 2020 Jun;261:114158
pubmed: 32088433
Environ Sci Pollut Res Int. 2020 Jan;27(2):2353-2360
pubmed: 31782094
Toxicol Res (Camb). 2016 Jul 19;5(5):1453-1464
pubmed: 30090449
Nanotoxicology. 2014 Sep;8(6):654-62
pubmed: 23834344
Andrologia. 2020 Feb;52(1):e13450
pubmed: 31692026
Hum Reprod. 2005 Sep;20(9):2559-66
pubmed: 15919771
Hum Reprod. 2007 Jan;22(1):188-96
pubmed: 16966350
Adv Exp Med Biol. 2012;733:125-33
pubmed: 22101718
Nanoscale Res Lett. 2018 Sep 4;13(1):266
pubmed: 30182198
Nanotoxicology. 2014 Aug;8 Suppl 1:118-27
pubmed: 24289310
Biol Trace Elem Res. 2017 Nov;180(1):81-89
pubmed: 28261763
Toxicol Sci. 2018 Feb 1;161(2):388-400
pubmed: 29069489
J Biomed Mater Res A. 2016 Jan;104(1):124-35
pubmed: 26238530
Bratisl Lek Listy. 2015;116(5):321-5
pubmed: 25924642
Environ Toxicol Pharmacol. 2015 Sep;40(2):626-38
pubmed: 26363132
Occup Environ Med. 2002 Apr;59(4):234-42
pubmed: 11934950
Toxicol Ind Health. 2017 Jun;33(6):519-529
pubmed: 28073318
Nanotoxicology. 2016;10(3):312-21
pubmed: 26923343
Chemosphere. 2018 Oct;208:942-950
pubmed: 30068038
Biomaterials. 2010 Mar;31(8):2034-42
pubmed: 20044133
Environ Health Perspect. 1996 Aug;104 Suppl 4:741-803
pubmed: 8880001
Am J Epidemiol. 2007 Jun 15;165(12):1372-9
pubmed: 17369608
Toxicol In Vitro. 2016 Sep;35:131-8
pubmed: 27247145
Int J Androl. 2009 Aug;32(4):337-42
pubmed: 18217983
Nat Nanotechnol. 2010 Sep;5(9):683-9
pubmed: 20693989
ACS Nano. 2012 Nov 27;6(11):9887-99
pubmed: 23046098
Nanoscale Res Lett. 2019 Jun 17;14(1):205
pubmed: 31209583
Nanotoxicology. 2016 Dec;10(10):1515-1525
pubmed: 27680428
Cells. 2020 Apr 26;9(5):
pubmed: 32357578
Toxicol Sci. 2010 Aug;116(2):577-89
pubmed: 20488942
Toxicol In Vitro. 2018 Aug;50:236-241
pubmed: 29625164
J Urol. 1999 Feb;161(2):460-2
pubmed: 9915426
Biomaterials. 2010 Nov;31(32):8350-61
pubmed: 20684985
Analyst. 2014 Mar 7;139(5):931-42
pubmed: 24171189
Int J Environ Res Public Health. 2016 Mar 01;13(3):
pubmed: 26938548
Int J Nanomedicine. 2016 Oct 11;11:5187-5203
pubmed: 27785022
Biol Reprod. 2014 Jul;91(1):20
pubmed: 24899576
Int J Mol Sci. 2019 Aug 19;20(16):
pubmed: 31430870
Hum Reprod Update. 2016 Sep;22(5):588-619
pubmed: 27385359
J Biomed Nanotechnol. 2020 May 1;16(5):659-671
pubmed: 32919486
Reprod Toxicol. 2010 Nov;30(3):343-52
pubmed: 20600821
Toxicol In Vitro. 2008 Dec;22(8):1825-31
pubmed: 18805477
Environ Sci Pollut Res Int. 2019 Oct;26(28):29074-29084
pubmed: 31392614
Part Fibre Toxicol. 2018 Jan 31;15(1):10
pubmed: 29386028
Part Fibre Toxicol. 2013 Aug 01;10:36
pubmed: 24059869
Environ Toxicol. 2020 Sep;35(9):952-960
pubmed: 32293792
Biomaterials. 2016 Jan;76:302-12
pubmed: 26561929
Nanotoxicology. 2016;10(3):361-73
pubmed: 26470004
Langmuir. 2012 Dec 11;28(49):16966-78
pubmed: 23163331
Part Fibre Toxicol. 2010 Aug 06;7:20
pubmed: 20691052
Biol Trace Elem Res. 2017 Jan;175(1):50-56
pubmed: 27260534
J Toxicol Sci. 2017;42(3):359-366
pubmed: 28496042
Fertil Steril. 1998 Jul;70(1):76-80
pubmed: 9660425
Int J Mol Sci. 2013 Aug 14;14(8):16732-801
pubmed: 23949635
J Toxicol Environ Health A. 2013;76(17):1023-32
pubmed: 24168038
Arch Toxicol. 2014 Mar;88(3):781-8
pubmed: 24241477
Mater Sci Eng C Mater Biol Appl. 2018 Oct 1;91:372-381
pubmed: 30033267
PLoS One. 2018 Jul 20;13(7):e0200238
pubmed: 30028835
ACS Nano. 2012 Aug 28;6(8):7427-42
pubmed: 22857815
Inhal Toxicol. 2009 Aug;21(10):803-11
pubmed: 19653803
Environ Sci Pollut Res Int. 2017 Feb;24(6):5595-5606
pubmed: 28035607
Am J Sports Med. 2014 Nov;42(11):2761-8
pubmed: 23925575
Int J Nanomedicine. 2019 Dec 06;14:9677-9692
pubmed: 31827324
Environ Pollut. 2019 Dec;255(Pt 1):113172
pubmed: 31541822
Reprod Toxicol. 2013 Apr;36:88-97
pubmed: 23295323
Toxicol Ind Health. 2018 Sep;34(9):640-652
pubmed: 30003841
Reprod Toxicol. 1988;2(3-4):155-61
pubmed: 2980340
J Appl Toxicol. 2016 Mar;36(3):474-8
pubmed: 26584657
J Biomed Nanotechnol. 2019 Mar 1;15(3):571-580
pubmed: 31165701
BMJ. 1992 Sep 12;305(6854):609-13
pubmed: 1393072
Environ Toxicol. 2017 Feb;32(2):594-608
pubmed: 26991130
World J Urol. 2017 Jan;35(1):173-175
pubmed: 27221802
Appl Biochem Biotechnol. 2015 Jan;175(2):825-40
pubmed: 25344432
Toxicol In Vitro. 2017 Apr;40:214-222
pubmed: 28130145
Small. 2013 May 27;9(9-10):1708-14
pubmed: 22911975
Iran J Reprod Med. 2013 Sep;11(9):767-71
pubmed: 24639818
Int J Nanomedicine. 2019 Dec 04;14:9563-9576
pubmed: 31824151
Reprod Toxicol. 2016 Apr;60:133-9
pubmed: 26900051
Molecules. 2020 Feb 27;25(5):
pubmed: 32120976
PLoS One. 2014 Jul 08;9(7):e101572
pubmed: 25003337
PLoS One. 2015 May 21;10(5):e0127174
pubmed: 25996496
J Nat Sci Biol Med. 2015 Jul-Dec;6(2):335-9
pubmed: 26283824
Environ Sci Technol. 2018 Sep 4;52(17):9666-9676
pubmed: 30059221
Toxicology. 2012 Jan 27;291(1-3):65-72
pubmed: 22085606
Sci Rep. 2016 Aug 19;6:30270
pubmed: 27538480
Reprod Toxicol. 2014 Jun;45:59-70
pubmed: 24447867
Langmuir. 2006 Nov 7;22(23):9480-2
pubmed: 17073466
Sci Rep. 2015 Jun 08;5:11170
pubmed: 26054035
Toxicol Lett. 2009 Feb 25;185(1):1-8
pubmed: 19100318
Small. 2015 Apr 8;11(14):1683-90
pubmed: 25408470
Environ Sci Pollut Res Int. 2019 Oct;26(28):28749-28762
pubmed: 31376127
Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):605-10
pubmed: 18195365
Int J Nanomedicine. 2016 Jul 27;11:3475-85
pubmed: 27555769
Sci Rep. 2015 Aug 11;5:12938
pubmed: 26263183
Toxicol Ind Health. 2017 Nov;33(11):821-834
pubmed: 28950792
Biomed Microdevices. 2013 Jun;15(3):427-36
pubmed: 23329290
Hum Exp Toxicol. 2020 Sep;39(9):1147-1167
pubmed: 31957491