Cerebral Folate Metabolism in Post-Mortem Alzheimer's Disease Tissues: A Small Cohort Study.

Humans Alzheimer Disease / cerebrospinal fluid Cohort Studies Brain / metabolism Astrocytes / metabolism Folic Acid / metabolism Glial Fibrillary Acidic Protein / metabolism
ALDH1L1 Alzheimer’s disease astrocytes cerebral folate cerebrospinal fluid folate metabolism methylation neurons

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
30 Dec 2022
Historique:
received: 23 11 2022
accepted: 27 12 2022
entrez: 8 1 2023
pubmed: 9 1 2023
medline: 11 1 2023
Statut: epublish

Résumé

We investigated the cerebral folate system in post-mortem brains and matched cerebrospinal fluid (CSF) samples from subjects with definite Alzheimer's disease (AD) (

Identifiants

DOI: 10.3390/ijms24010660 PMID: 36614107 PMC: PMC9820589
pubmed: 36614107
pii: ijms24010660
doi: 10.3390/ijms24010660
pmc: PMC9820589
pii:
doi:

Substances chimiques

Folic Acid 935E97BOY8
Glial Fibrillary Acidic Protein 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Charles Wolfson Charitable Trust
ID : NA
Organisme : Africa Healthcare Development Trust
ID : NA

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Auteurs

Naila Naz (N)

Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine & Health, The University of Manchester, 3.540 Stopford Building, Oxford Road, Manchester M13 9PT, UK.

Syeda F Naqvi (SF)

Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine & Health, The University of Manchester, 3.540 Stopford Building, Oxford Road, Manchester M13 9PT, UK.
ORCID: 0000-0002-1861-4524

Nadine Hohn (N)

Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine & Health, The University of Manchester, 3.540 Stopford Building, Oxford Road, Manchester M13 9PT, UK.

Kiara Whelan (K)

Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine & Health, The University of Manchester, 3.540 Stopford Building, Oxford Road, Manchester M13 9PT, UK.
ORCID: 0000-0003-2499-7469

Phoebe Littler (P)

Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine & Health, The University of Manchester, 3.540 Stopford Building, Oxford Road, Manchester M13 9PT, UK.

Federico Roncaroli (F)

Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine & Health, The University of Manchester, 3.540 Stopford Building, Oxford Road, Manchester M13 9PT, UK.
Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre (MAHSC), The University of Manchester, Salford Royal Hospital, Salford M6 8HD, UK.
ORCID: 0000-0003-3650-5572

Andrew C Robinson (AC)

Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine & Health, The University of Manchester, 3.540 Stopford Building, Oxford Road, Manchester M13 9PT, UK.
Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre (MAHSC), The University of Manchester, Salford Royal Hospital, Salford M6 8HD, UK.
ORCID: 0000-0003-2208-7728

Jaleel A Miyan (JA)

Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine & Health, The University of Manchester, 3.540 Stopford Building, Oxford Road, Manchester M13 9PT, UK.
ORCID: 0000-0002-1835-0143

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cerebral Folate Metabolism in Post-Mortem...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Cerebral Folate Metabolism in Post-Mortem...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Cerebral Folate Metabolism in Post-Mortem...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Cerebral Folate Metabolism in Post-Mortem...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Cerebral Folate Metabolism in Post-Mortem...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Ptéridines › Acide folique › Cerebral Folate Metabolism in Post-Mortem...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines de filaments intermédiaires › Protéine gliofibrillaire acide › Cerebral Folate Metabolism in Post-Mortem...