The Role of SOX Transcription Factors in Ageing and Age-Related Diseases.
SOX
age-related diseases
ageing
neural stem cells
stem cell exhaustion
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
03 Jan 2023
03 Jan 2023
Historique:
received:
30
11
2022
revised:
27
12
2022
accepted:
28
12
2022
entrez:
8
1
2023
pubmed:
9
1
2023
medline:
11
1
2023
Statut:
epublish
Résumé
The quest for eternal youth and immortality is as old as humankind. Ageing is an inevitable physiological process accompanied by many functional declines that are driving factors for age-related diseases. Stem cell exhaustion is one of the major hallmarks of ageing. The SOX transcription factors play well-known roles in self-renewal and differentiation of both embryonic and adult stem cells. As a consequence of ageing, the repertoire of adult stem cells present in various organs steadily declines, and their dysfunction/death could lead to reduced regenerative potential and development of age-related diseases. Thus, restoring the function of aged stem cells, inducing their regenerative potential, and slowing down the ageing process are critical for improving the health span and, consequently, the lifespan of humans. Reprograming factors, including SOX family members, emerge as crucial players in rejuvenation. This review focuses on the roles of SOX transcription factors in stem cell exhaustion and age-related diseases, including neurodegenerative diseases, visual deterioration, chronic obstructive pulmonary disease, osteoporosis, and age-related cancers. A better understanding of the molecular mechanisms of ageing and the roles of SOX transcription factors in this process could open new avenues for developing novel strategies that will delay ageing and prevent age-related diseases.
Identifiants
pubmed: 36614288
pii: ijms24010851
doi: 10.3390/ijms24010851
pmc: PMC9821406
pii:
doi:
Substances chimiques
SOX Transcription Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education, Science and Technological Development of the Republic of Serbia
ID : 451-03-68/2022-14/200042
Organisme : Serbian Academy of Sciences and Arts
ID : F24
Organisme : Serbian Academy of Sciences and Arts
ID : F-172
Références
Nat Biotechnol. 2008 Jan;26(1):101-6
pubmed: 18059259
Nature. 2010 Mar 25;464(7288):504-12
pubmed: 20336132
PLoS Genet. 2011 Apr;7(4):e1001372
pubmed: 21533022
Clin Cancer Res. 2010 Jun 15;16(12):3141-52
pubmed: 20530696
Cytogenet Genome Res. 2004;105(2-4):442-7
pubmed: 15237232
Mol Biol Evol. 2021 Jul 29;38(8):3415-3435
pubmed: 33871658
J Cell Biol. 2005 Mar 28;168(7):1065-76
pubmed: 15781477
J Neurosci. 2009 May 13;29(19):6367-78
pubmed: 19439614
Development. 2012 Nov;139(21):3938-49
pubmed: 22992951
Cold Spring Harb Perspect Biol. 2017 Jul 5;9(7):
pubmed: 28062563
Genes Dev. 2006 May 1;20(9):1187-202
pubmed: 16651659
Front Cell Dev Biol. 2021 Sep 29;9:749131
pubmed: 34660607
J Neurosci. 2012 Feb 29;32(9):3067-80
pubmed: 22378879
PLoS One. 2009 Aug 28;4(8):e6827
pubmed: 19714249
Nat Rev Genet. 2020 Feb;21(2):88-101
pubmed: 31690828
Int Immunopharmacol. 2017 Apr;45:135-147
pubmed: 28213268
Oncogene. 2011 Jul 14;30(28):3105-26
pubmed: 21441951
Front Mol Neurosci. 2021 Mar 31;14:654031
pubmed: 33867936
Cancers (Basel). 2021 Jun 15;13(12):
pubmed: 34203877
Cell Tissue Res. 2015 Jan;359(1):111-24
pubmed: 24894327
An Acad Bras Cienc. 2015 Mar;87(1):389-404
pubmed: 25761220
Dev Neurosci. 2004 Mar-Aug;26(2-4):148-65
pubmed: 15711057
Epigenetics. 2012 Jul;7(7):680-8
pubmed: 22647267
Cancer. 2011 Apr 1;117(7):1516-28
pubmed: 21425153
Mech Ageing Dev. 2021 Mar;194:111432
pubmed: 33422562
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Clin Chem Lab Med. 2014 Dec;52(12):1843-50
pubmed: 24955525
BMJ Open Diabetes Res Care. 2020 Sep;8(1):
pubmed: 32873600
Neurobiol Aging. 2015 Jan;36(1):365-79
pubmed: 25172123
Trends Genet. 2000 Apr;16(4):182-7
pubmed: 10729834
Cell. 2008 Feb 22;132(4):681-96
pubmed: 18295583
Food Funct. 2014 Oct;5(10):2564-73
pubmed: 25138740
Eur J Neurosci. 2011 Mar;33(6):1139-51
pubmed: 21395858
BMC Cancer. 2015;15 Suppl 1:S1
pubmed: 25708542
Invest Ophthalmol Vis Sci. 2013 Dec 13;54(14):ORSF23-7
pubmed: 24335063
Ageing Res Rev. 2006 Feb;5(1):91-116
pubmed: 16310414
Stem Cells. 2009 Feb;27(2):442-50
pubmed: 19038788
J Biomater Appl. 2017 Nov;32(5):570-586
pubmed: 29113566
Best Pract Res Clin Gastroenterol. 2009;23(6):889-907
pubmed: 19942166
Gene Expr Patterns. 2013 Oct;13(7):240-8
pubmed: 23665444
Mediators Inflamm. 2014;2014:973986
pubmed: 25214721
J Neurosci. 2011 Nov 2;31(44):16033-44
pubmed: 22049445
Sci Rep. 2016 Aug 30;6:32350
pubmed: 27571710
Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1936-45
pubmed: 25825708
Cell Rep. 2022 Feb 1;38(5):110313
pubmed: 35108528
PLoS One. 2015 Nov 20;10(11):e0143591
pubmed: 26588701
BMC Evol Biol. 2016 Aug 31;16:173
pubmed: 27582319
Transl Res. 2014 May;163(5):456-65
pubmed: 24316383
Elife. 2022 Jan 28;11:
pubmed: 35089129
Trends Ecol Evol. 1999 Nov;14(11):438-442
pubmed: 10511720
Aging Cell. 2004 Aug;3(4):235-43
pubmed: 15268757
Cell. 2000 Jan 7;100(1):157-68
pubmed: 10647940
Nat Neurosci. 2003 Nov;6(11):1162-8
pubmed: 14517545
J Pers Med. 2021 May 18;11(5):
pubmed: 34070084
Expert Opin Drug Discov. 2020 Feb;15(2):135-138
pubmed: 31822135
J Cell Sci. 2007 Aug 15;120(Pt 16):2785-95
pubmed: 17652162
Physiol Genomics. 2005 Apr 14;21(2):253-63
pubmed: 15687482
Biochemistry (Mosc). 2014 Nov;79(11):1172-82
pubmed: 25540002
Front Aging Neurosci. 2021 Mar 11;12:609911
pubmed: 33776740
Int J Biochem Cell Biol. 2016 Mar;72:125-134
pubmed: 26806292
Mol Cells. 2018 Jun;41(6):575-581
pubmed: 29890823
J Neurosci. 2012 Sep 5;32(36):12543-57
pubmed: 22956844
Nat Genet. 2011 Jan;43(1):34-41
pubmed: 21113154
Evid Based Complement Alternat Med. 2019 Feb 19;2019:1765182
pubmed: 30911317
Crit Rev Oncol Hematol. 2008 Apr;66(1):65-74
pubmed: 17949989
Stem Cell Res Ther. 2018 Sep 26;9(1):244
pubmed: 30257716
PLoS One. 2016 May 12;11(5):e0155167
pubmed: 27171428
Commun Biol. 2022 Jun 9;5(1):565
pubmed: 35681050
J Biol Chem. 2003 Aug 8;278(32):29769-75
pubmed: 12782625
Dev Cell. 2002 Aug;3(2):167-70
pubmed: 12194848
Cancers (Basel). 2021 Mar 19;13(6):
pubmed: 33808654
Sci Rep. 2020 Apr 21;10(1):6751
pubmed: 32317665
Nat Neurosci. 2009 Apr;12(4):399-408
pubmed: 19287386
Osteoporos Int. 2012 Feb;23(2):781-7
pubmed: 21625884
J Alzheimers Dis. 2018;65(3):963-976
pubmed: 30103323
Glia. 2006 Dec;54(8):805-14
pubmed: 16958090
Exp Hematol. 2016 May;44(5):410-421.e5
pubmed: 26921649
Int J Mol Sci. 2019 Sep 13;20(18):
pubmed: 31540269
Nat Rev Mol Cell Biol. 2007 Sep;8(9):729-40
pubmed: 17667954
Knee Surg Sports Traumatol Arthrosc. 2014 Nov;22(11):2856-66
pubmed: 23503946
Cell. 2007 Aug 10;130(3):470-83
pubmed: 17655922
Sci Rep. 2015 Oct 19;5:15145
pubmed: 26477495
Curr Opin Genet Dev. 1997 Jun;7(3):338-44
pubmed: 9229109
Genes Dev. 2014 Jan 15;28(2):99-114
pubmed: 24449267
PLoS One. 2009 May 27;4(5):e5711
pubmed: 19479035
Stem Cell Res. 2017 Aug;23:20-32
pubmed: 28672156
Invest Ophthalmol Vis Sci. 2009 Jan;50(1):68-74
pubmed: 18719084
Rev Urol. 2008 Spring;10(2):111-9
pubmed: 18660852
Cell Cycle. 2012 Oct 1;11(19):3521-2
pubmed: 22935702
Cell Stem Cell. 2007 Nov;1(5):515-28
pubmed: 18371391
PLoS One. 2014 Jun 02;9(6):e97389
pubmed: 24887110
Nat Cell Biol. 2011 May;13(5):506-12
pubmed: 21540846
Development. 2009 Aug;136(16):2815-23
pubmed: 19605494
Neural Regen Res. 2022 Nov;17(11):2325-2334
pubmed: 35535866
J Bone Miner Res. 2011 Aug;26(8):1793-801
pubmed: 21452281
Cell Rep. 2014 Jul 24;8(2):487-500
pubmed: 25043184
Exp Neurol. 2022 Feb;348:113950
pubmed: 34902356
J Oncol. 2011;2011:
pubmed: 20936110
Nat Neurosci. 2010 Oct;13(10):1181-9
pubmed: 20871603
Stem Cells. 2020 Sep;38(9):1060-1077
pubmed: 32473067
Hepatology. 2011 Dec;54(6):2159-72
pubmed: 21809358
J Comp Neurol. 2010 Nov 1;518(21):4395-418
pubmed: 20852734
Biogerontology. 2018 Dec;19(6):547-566
pubmed: 29492790
World J Stem Cells. 2021 Oct 26;13(10):1417-1445
pubmed: 34786152
Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):
pubmed: 33597301
Biomolecules. 2021 Dec 28;12(1):
pubmed: 35053186
Cell. 2016 Dec 15;167(7):1719-1733.e12
pubmed: 27984723
EMBO J. 2007 Apr 4;26(7):1902-12
pubmed: 17363903
Neuron. 2003 Aug 28;39(5):749-65
pubmed: 12948443
J Biol Chem. 2005 Jul 1;280(26):24731-7
pubmed: 15860457
Brain Res. 2006 Jul 12;1099(1):8-17
pubmed: 16797497
Oncogene. 2009 Mar 26;28(12):1537-48
pubmed: 19219070
Neurobiol Aging. 2011 Jan;32(1):140-50
pubmed: 19201065
Lung India. 2018 Jul-Aug;35(4):321-327
pubmed: 29970772
Nat Neurosci. 2009 Oct;12(10):1248-56
pubmed: 19734891
Cell Stem Cell. 2010 Feb 5;6(2):103-15
pubmed: 20144784
Mech Ageing Dev. 2019 Jan;177:30-36
pubmed: 29574045
J Orthop Surg Res. 2021 May 18;16(1):321
pubmed: 34006298
J Neurosci. 2010 Aug 18;30(33):11222-31
pubmed: 20720130
Pharmacol Rev. 2012 Jan;64(1):88-101
pubmed: 22090473
PLoS One. 2017 Sep 19;12(9):e0184686
pubmed: 28926586
Nature. 2018 Oct;562(7728):578-582
pubmed: 30232451
Oncotarget. 2017 Nov 28;8(69):113598-113613
pubmed: 29371932
Cell Rep. 2015 Sep 29;12(12):2035-48
pubmed: 26365194
J Biol Chem. 2005 Jul 1;280(26):24371-9
pubmed: 15863505
Geroscience. 2020 Apr;42(2):409-428
pubmed: 31960269
Int J Mol Sci. 2022 Apr 30;23(9):
pubmed: 35563385
PLoS One. 2014 Mar 17;9(3):e91852
pubmed: 24637840
Science. 2010 Mar 26;327(5973):1650-3
pubmed: 20339075
Dev Biol. 2006 Jun 1;294(1):50-66
pubmed: 16554047
PLoS One. 2013;8(2):e57172
pubmed: 23451179
Nucleic Acids Res. 2013 Jan;41(Database issue):D1027-33
pubmed: 23193293
Gerontology. 2017;63(3):270-280
pubmed: 27825158
Neurobiol Aging. 2008 Jan;29(1):129-47
pubmed: 17092610
Aging Cell. 2018 Oct;17(5):e12834
pubmed: 30129215
Cell Res. 2009 Dec;19(12):1324-33
pubmed: 19823196
Gastroenterology. 2015 Nov;149(6):1553-1563.e10
pubmed: 26170137
Tech Coloproctol. 2014 Feb;18(2):129-35
pubmed: 24057357
Semin Cancer Biol. 2020 Dec;67(Pt 1):122-153
pubmed: 30914279
Sci Rep. 2016 Jun 14;6:27812
pubmed: 27298190
Development. 2004 Aug;131(15):3805-19
pubmed: 15240551
Development. 2009 Jun;136(11):1899-907
pubmed: 19403656
Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2907-12
pubmed: 18287078
Cancer Res. 2012 Mar 1;72(5):1301-15
pubmed: 22246670
Front Aging. 2022 Feb 04;3:820215
pubmed: 35821843
Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):20817-20819
pubmed: 31570569
Dev Cell. 2021 Feb 8;56(3):383-397.e8
pubmed: 33238152
BMC Musculoskelet Disord. 2017 Jan 26;18(1):46
pubmed: 28125982
Cell Stem Cell. 2011 Oct 4;9(4):317-29
pubmed: 21982232
Stem Cell Res Ther. 2020 May 25;11(1):199
pubmed: 32450920
J Am Geriatr Soc. 2013 Sep;61(9):1586-91
pubmed: 24001285
Curr Opin Neurobiol. 2005 Feb;15(1):7-13
pubmed: 15721738
Nat Rev Genet. 2013 Jun;14(6):427-39
pubmed: 23681063
Curr Genomics. 2018 Sep;19(6):464-482
pubmed: 30258277
Biomed Pharmacother. 2021 May;137:111327
pubmed: 33545662
Mol Ther. 2010 Nov;18(11):2018-27
pubmed: 20808289
Cell. 2012 Mar 2;148(5):1015-28
pubmed: 22385965
Drug Des Devel Ther. 2015 Feb 09;9:773-9
pubmed: 25709401
Nature. 2013 Oct 17;502(7471):340-5
pubmed: 24025773
Cold Spring Harb Perspect Biol. 2015 Apr 01;7(4):a021287
pubmed: 25833845
PLoS One. 2009 Dec 14;4(12):e8248
pubmed: 20011520
Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2060-2065
pubmed: 28167778
Cell Stem Cell. 2008 Jul 3;3(1):33-43
pubmed: 18593557
Cell Stem Cell. 2009 Dec 4;5(6):610-23
pubmed: 19951689
Nephrol Dial Transplant. 2016 Dec;31(12):2003-2011
pubmed: 26487673
Proc Natl Acad Sci U S A. 2009 May 12;106(19):7840-5
pubmed: 19416884
Geroscience. 2018 Aug;40(4):361-364
pubmed: 30084059
Cell Stem Cell. 2021 May 6;28(5):955-966.e7
pubmed: 33848469
Stem Cell Res. 2018 Apr;28:33-38
pubmed: 29414416
Mol Cell. 2016 Jun 2;62(5):728-44
pubmed: 27259204
Aging (Albany NY). 2012 Mar;4(3):176-86
pubmed: 22466406
J Cell Biol. 2011 Apr 18;193(2):257-66
pubmed: 21502357
Oncotarget. 2018 Nov 30;9(94):36684-36692
pubmed: 30613351
Sci Rep. 2018 Dec 5;8(1):17639
pubmed: 30518951
Nat Rev Mol Cell Biol. 2014 Jul;15(7):482-96
pubmed: 24954210
Mol Med Rep. 2020 Jun;21(6):2443-2451
pubmed: 32236601
Dev Biol. 2005 Jul 1;283(1):215-25
pubmed: 15893302
Curr Opin Immunol. 2010 Aug;22(4):507-13
pubmed: 20667703
Nature. 2006 Sep 28;443(7110):448-52
pubmed: 16957738
Genes Dev. 2011 Aug 1;25(15):1613-27
pubmed: 21828271
Am J Respir Crit Care Med. 2011 Jun 1;183(11):1482-9
pubmed: 21330457