Hepatotoxicity of Drugs Used in Multiple Sclerosis, Diagnostic Challenge, and the Role of HLA Genotype Susceptibility.
autoimmune hepatitis
drug-induced liver injury
liver injury
multiple sclerosis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
03 Jan 2023
03 Jan 2023
Historique:
received:
18
10
2022
revised:
23
12
2022
accepted:
27
12
2022
entrez:
8
1
2023
pubmed:
9
1
2023
medline:
11
1
2023
Statut:
epublish
Résumé
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system and the association with other autoimmune diseases is well-documented. There are many therapeutic options for the treatment of MS. Most of the available drugs cause drug-induced liver injury (DILI) to variable extents with heterogeneous clinical and biological manifestations, including liver injury with or without signs of hypersensitivity and autoimmunity. The diagnosis of DILI may be particularly difficult because MS is frequently associated with idiopathic autoimmune hepatitis. Recent advances suggest that MS and immune-mediated DILI could be promoted by genetic factors, including HLA genotype. In addition, some of these drugs may promote hepatitis B virus reactivation. This review explores the potential hepatotoxicity of drugs used to treat MS and the criteria to distinguish DILI from idiopathic autoimmune hepatitis associated with MS. The role of susceptible genes both promoting MS and causing the hepatotoxicity of the drug used for MS treatment is also discussed.
Identifiants
pubmed: 36614299
pii: ijms24010852
doi: 10.3390/ijms24010852
pmc: PMC9821303
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Drug Saf. 2003;26(11):815-27
pubmed: 12908850
Hepatology. 2011 Sep 2;54(3):931-9
pubmed: 21674554
N Engl J Med. 1994 Jul 14;331(2):134-5
pubmed: 8208266
Mult Scler Relat Disord. 2020 Jul;42:102065
pubmed: 32259746
Clin Res Hepatol Gastroenterol. 2020 Oct;44(5):662-673
pubmed: 31948782
Neurol Sci. 2008 Feb;29(1):29-31
pubmed: 18379737
Rev Neurol. 2012 Aug 1;55(3):190-2
pubmed: 22825980
Autoimmune Dis. 2011 Mar 28;2011:519450
pubmed: 21541245
Mult Scler. 2018 Mar;24(3):350-353
pubmed: 28273779
United European Gastroenterol J. 2019 Jul;7(6):825-837
pubmed: 31316787
Expert Opin Drug Saf. 2017 Feb;16(2):247-255
pubmed: 27989217
Mult Scler. 2005 Dec;11(6):691-3
pubmed: 16320729
Mult Scler Relat Disord. 2020 Nov;46:102572
pubmed: 33296971
Neurology. 2004 Feb 24;62(4):628-31
pubmed: 14981183
JAMA Neurol. 2017 Aug 1;74(8):961-969
pubmed: 28604916
J Hepatol. 2000;32(1 Suppl):77-88
pubmed: 10728796
Eur J Gastroenterol Hepatol. 2022 Apr 1;34(4):457-461
pubmed: 35230981
Lancet Neurol. 2018 Feb;17(2):162-173
pubmed: 29275977
Acta Neurol Scand. 2003 Feb;107(2):154-7
pubmed: 12580868
Clin Gastroenterol Hepatol. 2017 Jan;15(1):103-112.e2
pubmed: 27311619
Lancet Neurol. 2014 Mar;13(3):257-67
pubmed: 24502830
J Hepatol. 2019 Jun;70(6):1222-1261
pubmed: 30926241
Rev Rhum Engl Ed. 1999 Mar;66(3):169-72
pubmed: 10327497
Pharmacogenomics. 2016 Apr;17(5):489-98
pubmed: 27020477
Hepatology. 2020 Aug;72(2):671-722
pubmed: 31863477
Open Forum Infect Dis. 2018 Dec 26;6(1):ofy356
pubmed: 30697576
J Neurol. 2007 Jun;254(6):816-7
pubmed: 17351724
Brain Behav. 2018 Jun;8(6):e00968
pubmed: 29729087
CNS Drugs. 2021 Aug;35(8):861-880
pubmed: 34319570
Neurology. 2014 May 20;82(20):1846-7
pubmed: 24843037
Mult Scler. 2011 May;17(5):578-93
pubmed: 21228029
Front Pharmacol. 2019 Jul 26;10:837
pubmed: 31402866
J Hepatol. 2015 Oct;63(4):971-1004
pubmed: 26341719
Hepatology. 2010 Jun;51(6):2040-8
pubmed: 20512992
Mult Scler. 2019 Oct;25(12):1633-1640
pubmed: 30230957
N Engl J Med. 2010 Feb 4;362(5):416-26
pubmed: 20089960
Am J Gastroenterol. 2008 Aug;103(8):2147-8; author reply 2148
pubmed: 18796115
J Clin Gastroenterol. 2021 Nov-Dec 01;55(10):903-910
pubmed: 33074948
N Engl J Med. 2006 Mar 2;354(9):899-910
pubmed: 16510744
BMJ Case Rep. 2009;2009:
pubmed: 21686565
J Dig Dis. 2019 Mar;20(3):122-126
pubmed: 30582289
Medicine (Baltimore). 2021 Dec 23;100(51):e28246
pubmed: 34941096
Dig Dis Sci. 2013 Jun;58(6):1766-75
pubmed: 23377559
Mult Scler J Exp Transl Clin. 2019 Dec 09;5(4):2055217319894615
pubmed: 31839982
Gastroenterol Hepatol. 2015 Apr;38(4):280-1
pubmed: 25042243
Neurology. 2013 Aug 27;81(9):850-2
pubmed: 23884038
Liver Int. 2017 Mar;37(3):449-457
pubmed: 27541063
J Dig Dis. 2016 Jan;17(1):55-62
pubmed: 26676833
Ann Pharmacother. 2013 Sep;47(9):1153-60
pubmed: 24259730
Hepatology. 2022 Jul 27;:
pubmed: 35899384
Lancet. 1996 Jul 13;348(9020):129
pubmed: 8676694
Mult Scler Relat Disord. 2014 Nov;3(6):732-4
pubmed: 25891553
Int J Mol Sci. 2015 Dec 24;17(1):
pubmed: 26712744
Hepatology. 2010 Aug;52(2):730-42
pubmed: 20564754
Front Pharmacol. 2022 Feb 10;13:820724
pubmed: 35222034
N Engl J Med. 2011 Oct 6;365(14):1293-303
pubmed: 21991951
Mult Scler Relat Disord. 2014 Mar;3(2):266-8
pubmed: 25878015
Mult Scler Relat Disord. 2020 May;40:101948
pubmed: 31972518
Hepatology. 2008 Jul;48(1):169-76
pubmed: 18537184
Acta Neurol Belg. 2016 Mar;116(1):99-100
pubmed: 26141739
Clin Res Hepatol Gastroenterol. 2019 Jun;43(3):e25-e32
pubmed: 30594597
Curr Drug Saf. 2012 Apr;7(2):186-8
pubmed: 22873505
Aliment Pharmacol Ther. 2010 May;31(9):1028-35
pubmed: 20163378
Lancet. 2017 Apr 1;389(10076):1347-1356
pubmed: 27889192
Mult Scler. 2003 Dec;9(6):550-3
pubmed: 14664466
JAMA Neurol. 2019 Jul 1;76(7):866-867
pubmed: 30958517
Clin Liver Dis (Hoboken). 2021 Feb 28;17(2):85-89
pubmed: 33680442
Ther Adv Neurol Disord. 2017 Nov;10(11):367-372
pubmed: 29090021
Lancet. 1972 Jun 3;1(7762):1240-1
pubmed: 4113225
Mult Scler. 2017 Dec;23(14):1947-1949
pubmed: 28086032
Mult Scler. 2013 Aug;19(9):1234-5
pubmed: 23069876
Neurology. 2006 Mar 28;66(6):894-900
pubmed: 16567708
Arq Neuropsiquiatr. 2018 Oct;76(10):697-704
pubmed: 30427510
Neurology. 2010 Jun 8;74(23):1905-10
pubmed: 20530326
Dig Liver Dis. 2012 Apr;44(4):356-7
pubmed: 22154948
Genome Med. 2017 May 31;9(1):50
pubmed: 28569182
J Investig Med High Impact Case Rep. 2013 Dec 17;1(4):2324709613517493
pubmed: 26425591