Low Serum Vitamin D Status Is Associated with Incident Alzheimer's Dementia in the Oldest Old.
Alzheimer’s disease dementia
apolipoprotein E ε4
beta-carotene
dementia
elderly
vitamin D
vitamins
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
23 Dec 2022
23 Dec 2022
Historique:
received:
23
11
2022
revised:
14
12
2022
accepted:
16
12
2022
entrez:
8
1
2023
pubmed:
9
1
2023
medline:
11
1
2023
Statut:
epublish
Résumé
Background. Vitamins A, D and E and beta-carotene may have a protective function for cognitive health, due to their antioxidant capacities. Methods. We analyzed data from 1334 non-demented participants (mean age 84 years) from the AgeCoDe study, a prospective multicenter-cohort of elderly general-practitioner patients in Germany, of whom n = 250 developed all-cause dementia and n = 209 developed Alzheimer’s dementia (AD) during 7 years of follow-up. We examined whether concentrations of vitamins A (retinol), D (25-hydroxycholecalciferol) and E (alpha-tocopherol) and beta-carotene, would be associated with incident (AD) dementia. Results. In our sample, 33.7% had optimum vitamin D concentrations (≥50 nmol/L). Higher concentrations of vitamin D were associated with lower incidence of all-cause dementia and AD (HR 0.99 (95%CI 0.98; 0.99); HR0.99 (95%CI 0.98; 0.99), respectively). In particular, subjects with vitamin D deficiency (25.3%, <25 nmol/L) were at increased risk for all-cause dementia and AD (HR1.91 (95%CI 1.30; 2.81); HR2.28 (95%CI 1.47; 3.53), respectively). Vitamins A and E and beta-carotene were unrelated to (AD) dementia. Conclusions. Vitamin D deficiency increased the risk to develop (AD) dementia. Our study supports the advice for monitoring vitamin D status in the elderly and vitamin D supplementation in those with vitamin D deficiency. We observed no relationships between the other vitamins with incident (AD) dementia, which is in line with previous observational studies.
Identifiants
pubmed: 36615719
pii: nu15010061
doi: 10.3390/nu15010061
pmc: PMC9824107
pii:
doi:
Substances chimiques
beta Carotene
01YAE03M7J
Vitamins
0
Vitamin D
1406-16-2
Vitamin A
11103-57-4
Tocopherols
R0ZB2556P8
Types de publication
Multicenter Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Federal Ministry of Education and Research
ID : 01EA1372D
Organisme : Federal Ministry of Education and Research
ID : 01EA1410C
Organisme : Alzheimer Forschung Initiative
ID : Travel grant
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