Association of
CYP2D6
analgesia
opioid adverse effects
oxycodone
pharmacogenetics
postoperative pain
Journal
Annals of translational medicine
ISSN: 2305-5839
Titre abrégé: Ann Transl Med
Pays: China
ID NLM: 101617978
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
03
10
2022
accepted:
23
10
2022
entrez:
9
1
2023
pubmed:
10
1
2023
medline:
10
1
2023
Statut:
ppublish
Résumé
Oxycodone is a commonly used oral opioid in children for treating postoperative pain. Highly polymorphic gene Patients who underwent Nuss procedure and spine fusion with Of 193 subjects (age 15.9±0.25 years, 28.5% female, 93.78% White; 101 NM, 76 IM, 10 PM and 6 UM), 77.72% underwent pectus surgery. Our findings suggest
Sections du résumé
Background
UNASSIGNED
Oxycodone is a commonly used oral opioid in children for treating postoperative pain. Highly polymorphic gene
Methods
UNASSIGNED
Patients who underwent Nuss procedure and spine fusion with
Results
UNASSIGNED
Of 193 subjects (age 15.9±0.25 years, 28.5% female, 93.78% White; 101 NM, 76 IM, 10 PM and 6 UM), 77.72% underwent pectus surgery.
Conclusions
UNASSIGNED
Our findings suggest
Identifiants
pubmed: 36618804
doi: 10.21037/atm-2022-58
pii: atm-10-23-1262
pmc: PMC9816853
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1262Informations de copyright
2022 Annals of Translational Medicine. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://atm.amegroups.com/article/view/10.21037/atm-2022-58/coif). SM declares single site eMERGE II project initiated and funded by the NHGRI through grants U01HG006828 and U01HG004438 (Prows); research reported in this publication was supported by the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health under Award Numbers, R01HD089458 (PI: Sadhasivam), R21HD094311(PI: Sadhasivam) and R01HD096800 (PI: Sadhasivam). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. CAP received funding from National Human Genome Research Institute at National Institutes of Health, USA, through grants U01HG006828 and U01HG004438, Elsevier Inc. ($250, chapter in Wong’s Nursing Care of Infants and Children, 12th edition), and Patent US 10,662,476 B2—Personalized pain management and anesthesia: preemptive risk identification and therapeutic decision support. SS received funding from R01HD089458 (PI: Sadhasivam), R21HD094311(PI: Sadhasivam), R01HD096800 (PI: Sadhasivam), R01HD089458 (PI: Sadhasivam), R21HD094311(PI: Sadhasivam) and R01HD096800 (PI: Sadhasivam). And received pay from UpToDate: Anesthesia for Tonsillectomy and NeurOptics: Morphine in Tonsillectomy. SS is one of the inventors in the approved U.S. patents focused on opioid pharmacogenetics: U.S. Patent No. 9944985, 10662476, 16/850537, 16/946401, 16/946399, 10878939. He is the founder and chief medical officer of OpalGenix, Inc. There is no financial conflict with the current article. 9944985, 10662476, 16/946401, 16/850537 also include Dr. Chidambaran and Cindy Prows. The other authors have no conflicts of interest to declare.
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