Evolving roles of activins and inhibins in ovarian cancer pathophysiology.
TGFβ superfamily
activin
inhibin
ovarian cancer
tumor immune environment
Journal
American journal of physiology. Cell physiology
ISSN: 1522-1563
Titre abrégé: Am J Physiol Cell Physiol
Pays: United States
ID NLM: 100901225
Informations de publication
Date de publication:
01 02 2023
01 02 2023
Historique:
pmc-release:
01
02
2024
pubmed:
10
1
2023
medline:
8
2
2023
entrez:
9
1
2023
Statut:
ppublish
Résumé
Activins and inhibins are unique members of the transforming growth factor-β (TGFβ) family of growth factors, with the ability to exert autocrine, endocrine, and paracrine effects in a wide range of complex physiologic and pathologic processes. Although first isolated within the pituitary, emerging evidence suggests broader influence beyond reproductive development and function. Known roles of activin and inhibin in angiogenesis and immunity along with correlations between gene expression and cancer prognosis suggest potential roles in tumorigenesis. Here, we present a review of the current understanding of the biological role of activins and inhibins as it relates to ovarian cancers, summarizing the underlying signaling mechanisms and physiologic influence, followed by detailing their roles in cancer progression, diagnosis, and treatment.
Identifiants
pubmed: 36622068
doi: 10.1152/ajpcell.00178.2022
pmc: PMC9902228
doi:
Substances chimiques
Inhibins
57285-09-3
Activins
104625-48-1
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
C428-C437Subventions
Organisme : NCI NIH HHS
ID : R01 CA219495
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA229102
Pays : United States
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