The diagnostic accuracy of 332 incisional biopsies in patients with malignant tumors in the musculoskeletal system.
Bone tumor
Core needle biopsy
Incisional biopsy
Lymphoma
Metastasis
Soft tissue sarcoma
Journal
World journal of surgical oncology
ISSN: 1477-7819
Titre abrégé: World J Surg Oncol
Pays: England
ID NLM: 101170544
Informations de publication
Date de publication:
09 Jan 2023
09 Jan 2023
Historique:
received:
21
09
2022
accepted:
29
12
2022
entrez:
9
1
2023
pubmed:
10
1
2023
medline:
12
1
2023
Statut:
epublish
Résumé
It is known that specimen collection followed by histopathological workup is the core of evidence-based medical therapy of musculoskeletal tumors. There exist many controversies about how a biopsy should be performed. While some centers recommend minimal invasive biopsy procedures, mostly the core needle biopsy (CNB), others prefer the incisional biopsy. This study aimed to determine the accuracy of incisional biopsy for malignant tumors in the musculoskeletal system. Moreover, advantages and disadvantages to other biopsy methods are discussed. This retrospective, single-center study about 844 incisional biopsies (benign and malignant) analysis the diagnostic accuracy of 332 malignant tumors, concerning the final histopathological result. In addition, surgical complications are analyzed to find the best way to plan and treat patients timely and correct. Secondary endpoints are the patients age, the pure operation time, as well as the type of tumor, and the subsequent therapy. In summary, incisional biopsy corresponded a sensitivity of 100% for malignancy in 844 incisional biopsies and a specificity of 97.6% in 332 malignant tumors, but it features greater operative expense (incision/suture 23.5 min) and the risk of general anesthesia. The method of biopsy should be tailored to the individual patient and the experience of the center performing the procedure.
Sections du résumé
BACKGROUND
BACKGROUND
It is known that specimen collection followed by histopathological workup is the core of evidence-based medical therapy of musculoskeletal tumors. There exist many controversies about how a biopsy should be performed. While some centers recommend minimal invasive biopsy procedures, mostly the core needle biopsy (CNB), others prefer the incisional biopsy.
PURPOSE OF THE STUDY
OBJECTIVE
This study aimed to determine the accuracy of incisional biopsy for malignant tumors in the musculoskeletal system. Moreover, advantages and disadvantages to other biopsy methods are discussed.
METHODS
METHODS
This retrospective, single-center study about 844 incisional biopsies (benign and malignant) analysis the diagnostic accuracy of 332 malignant tumors, concerning the final histopathological result. In addition, surgical complications are analyzed to find the best way to plan and treat patients timely and correct. Secondary endpoints are the patients age, the pure operation time, as well as the type of tumor, and the subsequent therapy.
RESULTS
RESULTS
In summary, incisional biopsy corresponded a sensitivity of 100% for malignancy in 844 incisional biopsies and a specificity of 97.6% in 332 malignant tumors, but it features greater operative expense (incision/suture 23.5 min) and the risk of general anesthesia.
CONCLUSION
CONCLUSIONS
The method of biopsy should be tailored to the individual patient and the experience of the center performing the procedure.
Identifiants
pubmed: 36624456
doi: 10.1186/s12957-022-02883-w
pii: 10.1186/s12957-022-02883-w
pmc: PMC9827702
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4Informations de copyright
© 2023. The Author(s).
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