Circadian disruption in lung fibroblasts enhances NF-κB activity to exacerbate neutrophil recruitment.
Bmal1−/−
circadian rhythms
fibroblasts
immune signaling
inflammation
lung
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
revised:
08
12
2022
received:
08
09
2022
accepted:
21
12
2022
entrez:
10
1
2023
pubmed:
11
1
2023
medline:
12
1
2023
Statut:
ppublish
Résumé
Fibroblasts are stromal cells abundant throughout tissues, including the lungs. Fibroblasts are integral coordinators of immune cell recruitment through chemokine secretion. Circadian rhythms direct the recruitment of immune cells to the lung, which in turn impacts response to infection and survival. Although fibroblasts display robust circadian rhythms, the contribution of the fibroblast molecular clock to lung-specific migration of immune cells and recruitment remains to be established. Mice challenged intranasally with lipopolysaccharide (LPS) at dusk showed increased expression of the pro-inflammatory cytokine IL-1β and chemokine CXCL5 in the lung, which was accompanied by increased neutrophil recruitment. Primary lung fibroblasts with knockdown of the core clock gene Bmal1 and immortalized Bmal1
Identifiants
pubmed: 36624683
doi: 10.1096/fj.202201456R
pmc: PMC10107448
doi:
Substances chimiques
NF-kappa B
0
ARNTL Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22753Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL155934
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL147472
Pays : United States
Informations de copyright
© 2023 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.
Références
Cell. 2000 Dec 22;103(7):1009-17
pubmed: 11163178
Biochem Biophys Res Commun. 2009 Jan 2;378(1):90-4
pubmed: 19007749
Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1139-1147
pubmed: 31879343
Nat Commun. 2014 Sep 11;5:4753
pubmed: 25208554
Pulm Ther. 2018 Jun;4(1):29-43
pubmed: 32026248
PLoS Genet. 2021 Nov 22;17(11):e1009933
pubmed: 34807912
Am J Respir Crit Care Med. 2008 Aug 1;178(3):248-60
pubmed: 18467512
J Virol. 2005 May;79(10):6441-8
pubmed: 15858027
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12662-7
pubmed: 22778400
Am J Respir Crit Care Med. 2017 Aug 1;196(3):283-297
pubmed: 28252317
Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1056-75
pubmed: 26361874
Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8460-E8468
pubmed: 30127006
Neoplasia. 2021 Mar;23(3):326-336
pubmed: 33621853
Oncoimmunology. 2022 Apr 7;11(1):2059876
pubmed: 35402081
Int J Mol Sci. 2021 Nov 10;22(22):
pubmed: 34830058
Arthritis Res Ther. 2019 Jan 6;21(1):5
pubmed: 30612576
Eur Respir J. 2011 Nov;38(5):1019-28
pubmed: 21622588
Curr Biol. 2013 Mar 4;23(5):372-81
pubmed: 23434278
Sci Rep. 2015 Apr 29;4:9927
pubmed: 25923474
Sci Rep. 2018 Oct 25;8(1):15768
pubmed: 30361541
Trends Cancer. 2019 Aug;5(8):475-494
pubmed: 31421905
Annu Rev Genomics Hum Genet. 2004;5:407-41
pubmed: 15485355
Sci Transl Med. 2016 Feb 3;8(324):324ra16
pubmed: 26843191
Semin Immunol. 2016 Oct;28(5):478-490
pubmed: 27884543
FASEB J. 2023 Feb;37(2):e22753
pubmed: 36624683
Nat Commun. 2019 Sep 11;10(1):4107
pubmed: 31511530
Diabetes Obes Metab. 2011 Aug;13(8):750-8
pubmed: 21447040
Immunity. 2021 May 11;54(5):903-915
pubmed: 33979587
Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):16089-94
pubmed: 14657355
Nat Methods. 2017 Nov;14(11):1083-1086
pubmed: 28991892
Am Rev Respir Dis. 1982 Aug;126(2):332-7
pubmed: 7103258
Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16219-24
pubmed: 25349387
Ann Med. 2019 Aug - Sep;51(5-6):314-329
pubmed: 31269827
Respir Res. 2013 Oct 21;14:112
pubmed: 24143997
FASEB J. 2014 Jan;28(1):176-94
pubmed: 24025728
F1000Res. 2019 Apr 26;8:
pubmed: 31069060
Cancer Prev Res (Phila). 2008 Oct;1(5):316-28
pubmed: 19138976
Front Immunol. 2021 Nov 09;12:700431
pubmed: 34858390
Immunol Rev. 2021 Jul;302(1):86-103
pubmed: 34101202
Nat Med. 2014 Aug;20(8):919-26
pubmed: 25064128
Am J Respir Cell Mol Biol. 2013 May;48(5):531-9
pubmed: 23328639
Am J Respir Crit Care Med. 1999 Nov;160(5 Pt 1):1532-9
pubmed: 10556116
EMBO J. 2021 Apr 1;40(7):e106745
pubmed: 33491228
Prog Mol Biol Transl Sci. 2013;119:325-46
pubmed: 23899602
Am J Physiol. 1999 Dec;277(6):L1149-57
pubmed: 10600885
Thorax. 1975 Jun;30(3):300-5
pubmed: 167466
Trends Cell Biol. 2014 Feb;24(2):90-9
pubmed: 23916625
Cell. 2019 May 2;177(4):896-909.e20
pubmed: 31030999
Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2457-65
pubmed: 22895791