Inhibition of Nicotine Metabolism by Cannabidiol (CBD) and 7-Hydroxycannabidiol (7-OH-CBD).
Journal
Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448
Informations de publication
Date de publication:
20 02 2023
20 02 2023
Historique:
pubmed:
11
1
2023
medline:
25
2
2023
entrez:
10
1
2023
Statut:
ppublish
Résumé
Cannabis-based products have experienced notable increases in co-usage alongside tobacco products. Several cannabinoids exhibit inhibition of a number of cytochrome P450 (CYP) and UDP glucuronosyltransferase (UGT) enzymes, but few studies have examined their inhibition of enzymes involved in nicotine metabolism. The goal of the present study was to examine potential drug-drug interactions occurring in the nicotine metabolism pathway perpetrated by cannabidiol (CBD) and its active metabolite, 7-hydroxy-CBD (7-OH-CBD). The inhibitory effects of CBD and 7-OH-CBD were tested in microsomes from HEK293 cells overexpressing individual metabolizing enzymes and from human liver tissue. Assays with overexpressing microsomes demonstrated that CBD and 7-OH-CBD inhibited CYP-mediated nicotine metabolism. Binding-corrected IC
Identifiants
pubmed: 36626330
doi: 10.1021/acs.chemrestox.2c00259
pmc: PMC9945182
doi:
Substances chimiques
Cannabidiol
19GBJ60SN5
Cannabinoids
0
Cotinine
K5161X06LL
Cytochrome P-450 CYP2A6
EC 1.14.14.1
Cytochrome P-450 CYP2B6
EC 1.14.14.1
Cytochrome P-450 Enzyme System
9035-51-2
Nicotine
6M3C89ZY6R
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
177-187Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES025460
Pays : United States
Références
Nicotine Tob Res. 2021 Aug 29;23(10):1735-1743
pubmed: 33823003
Neuropharmacology. 2014 Jan;76 Pt B:533-44
pubmed: 24055497
Mol Psychiatry. 2021 Jun;26(6):2212-2223
pubmed: 32157176
Br J Pharmacol. 2008 Jan;153(2):199-215
pubmed: 17828291
J Med Pharm Chem. 1961 Jul 1;4:21-30
pubmed: 14004224
J Expo Sci Environ Epidemiol. 2013 Sep-Oct;23(5):513-8
pubmed: 23443235
CNS Drugs. 2018 Nov;32(11):1053-1067
pubmed: 30374683
J Pharmacol Exp Ther. 2004 Jan;308(1):189-97
pubmed: 14563790
J Vet Pharmacol Ther. 2010 Aug;33(4):341-6
pubmed: 20646194
Expert Opin Drug Metab Toxicol. 2021 Mar;17(3):333-349
pubmed: 33322962
Carcinogenesis. 2016 Mar;37(3):269-279
pubmed: 26818358
Clin Pharmacol Ther. 1994 Nov;56(5):483-93
pubmed: 7955812
Chem Res Toxicol. 2005 Dec;18(12):1792-8
pubmed: 16359169
Drug Metab Dispos. 2006 Mar;34(3):449-56
pubmed: 16381668
Drug Alcohol Depend. 2018 Sep 1;190:89-93
pubmed: 29990649
Pharmacol Biochem Behav. 2000 Jul;66(3):553-8
pubmed: 10899369
Drug Metab Dispos. 2005 Aug;33(8):1166-73
pubmed: 15860657
Drug Metab Dispos. 1996 May;24(5):610-4
pubmed: 8723744
Addiction. 2018 May 1;:
pubmed: 29714034
Drug Metab Dispos. 2001 Jun;29(6):897-902
pubmed: 11353760
Addict Behav. 2013 Sep;38(9):2433-6
pubmed: 23685330
Pharmacol Ther. 2019 Sep;201:25-38
pubmed: 31071346
Sci Rep. 2015 Apr 17;5:9627
pubmed: 25884245
Br J Clin Pharmacol. 2000 Dec;50(6):553-61
pubmed: 11136294
Pharmazie. 2020 Oct 1;75(10):463-469
pubmed: 33305718
Drug Metab Pharmacokinet. 2008;23(6):412-20
pubmed: 19122335
Drug Metab Dispos. 2016 Mar;44(3):378-88
pubmed: 26669329
J Pharmacol Exp Ther. 2008 Mar;324(3):992-9
pubmed: 18065502
Cancer Res. 2010 Oct 1;70(19):7543-52
pubmed: 20876810
Drug Metab Dispos. 2023 Jan;51(1):29-37
pubmed: 35197312
Annu Rev Pharmacol Toxicol. 2009;49:57-71
pubmed: 18834313
Pharmacogenomics J. 2006 Mar-Apr;6(2):115-9
pubmed: 16402086
Mol Pharmacol. 2007 Sep;72(3):761-8
pubmed: 17576790
Pharmacogenet Genomics. 2012 Mar;22(3):183-90
pubmed: 22228205
Drug Metab Dispos. 2000 Oct;28(10):1149-52
pubmed: 10997932
Drug Metab Dispos. 2001 Mar;29(3):217-22
pubmed: 11181487
Br J Clin Pharmacol. 2000 Oct;50(4):311-4
pubmed: 11012553
Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):17-28
pubmed: 19475569
Drug Metab Dispos. 2006 Jun;34(6):943-9
pubmed: 16510539
Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12493-7
pubmed: 11050152
Cancer Epidemiol Biomarkers Prev. 2019 Feb;28(2):311-320
pubmed: 30381441
J Pharmacol Exp Ther. 1996 May;277(2):1010-5
pubmed: 8627511
Hum Mol Genet. 2012 Jul 1;21(13):3050-62
pubmed: 22451501
Arch Toxicol. 1999 Mar;73(2):65-70
pubmed: 10350185
Drug Metab Pharmacokinet. 2015 Feb;30(1):64-9
pubmed: 25760531
Drug Metab Dispos. 2021 Dec;49(12):1070-1080
pubmed: 34493602
Biopharm Drug Dispos. 2006 Jan;27(1):1-6
pubmed: 16278927
Nature. 1998 Jun 25;393(6687):750
pubmed: 9655391
Exp Clin Psychopharmacol. 2019 Jun;27(3):265-275
pubmed: 30556733
Psychopharmacology (Berl). 2011 Nov;218(2):313-22
pubmed: 21597990
Drug Metab Dispos. 2021 Oct;49(10):882-891
pubmed: 34330718
Biochem Biophys Res Commun. 1979 Dec 14;91(3):991-6
pubmed: 43154
J Pers Med. 2017 Dec 01;7(4):
pubmed: 29194389
Nicotine Tob Res. 2010 May;12(5):474-82
pubmed: 20231241
Drug Metab Dispos. 2021 Dec;49(12):1081-1089
pubmed: 34493601
Cochrane Database Syst Rev. 2017 Sep 08;9:CD011823
pubmed: 28884473
Drug Metab Dispos. 2005 Dec;33(12):1760-4
pubmed: 16174803
Drug Metab Dispos. 2005 Dec;33(12):1811-8
pubmed: 16135656
J Clin Med Res. 2020 Mar;12(3):129-141
pubmed: 32231748
Carcinogenesis. 2004 Dec;25(12):2451-8
pubmed: 15308589
Drug Metab Dispos. 2020 Oct;48(10):1008-1017
pubmed: 32587099
Drug Metab Dispos. 2022 Apr;50(4):351-360
pubmed: 35115300
Cancer Res. 2007 Oct 1;67(19):9024-9
pubmed: 17909004
Biochem Pharmacol. 2018 Oct;156:32-42
pubmed: 30086285
J Pharmacol Exp Ther. 2012 Nov;343(2):307-15
pubmed: 22869927
Am J Public Health. 2018 Jan;108(1):137-142
pubmed: 29161058
Arch Biochem Biophys. 1997 May 1;341(1):47-61
pubmed: 9143352
Drug Metab Dispos. 2001 Apr;29(4 Pt 2):548-52
pubmed: 11259349
Drug Metab Dispos. 1996 Nov;24(11):1212-7
pubmed: 8937855
Cancer Epidemiol Biomarkers Prev. 2023 Jan 9;32(1):54-65
pubmed: 36252563
Eur J Drug Metab Pharmacokinet. 1982 Oct-Dec;7(4):293-8
pubmed: 7166181
Pharmacol Ther. 2009 Jul;123(1):1-16
pubmed: 19362108
Addict Sci Clin Pract. 2010 Dec;5(2):17-29
pubmed: 22002450