Novel Diarylthioether Compounds as Agents for the Treatment of Chagas Disease.

Mice Animals Trypanocidal Agents / pharmacology Chagas Disease / drug therapy Trypanosoma cruzi Structure-Activity Relationship Drug Discovery

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
26 01 2023
Historique:
pubmed: 11 1 2023
medline: 28 1 2023
entrez: 10 1 2023
Statut: ppublish

Résumé

Herein, we describe the hit optimization of a novel diarylthioether chemical class found to be active against

Identifiants

DOI: 10.1021/acs.jmedchem.2c01725 PMID: 36626662
pubmed: 36626662
doi: 10.1021/acs.jmedchem.2c01725
doi:

Substances chimiques

Trypanocidal Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1522-1542

Auteurs

Julia Beveridge (J)

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Australian Translational Medicinal Chemistry Facility (ATMCF), Monash University, Parkville, Victoria 3052, Australia.
ORCID: 0000-0002-9425-8832

Eric Tran (E)

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Australian Translational Medicinal Chemistry Facility (ATMCF), Monash University, Parkville, Victoria 3052, Australia.

Girdhar Singh Deora (GS)

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Australian Translational Medicinal Chemistry Facility (ATMCF), Monash University, Parkville, Victoria 3052, Australia.
ORCID: 0000-0001-9857-101X

Fei Huang (F)

School of Pharmaceutical Sciences, Nanjing Tech University, No. 30 South Puzhu Road, Nanjing 211816, China.
ORCID: 0000-0002-5290-2490

Yuzhi Wang (Y)

School of Pharmaceutical Sciences, Nanjing Tech University, No. 30 South Puzhu Road, Nanjing 211816, China.

Kieran Stockton (K)

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Australian Translational Medicinal Chemistry Facility (ATMCF), Monash University, Parkville, Victoria 3052, Australia.

Ignacio Cotillo (I)

GlaxoSmithKline, 28760 Tres Cantos, Spain.

Maria Santos Martinez Martinez (MS)

GlaxoSmithKline, 28760 Tres Cantos, Spain.

Silvia Gonzalez (S)

GlaxoSmithKline, 28760 Tres Cantos, Spain.

Pablo Castañeda (P)

GlaxoSmithKline, 28760 Tres Cantos, Spain.

Julian Sherman (J)

Department of Microbiology, New York University School of Medicine, New York, New York 10016, United States.

Ana Rodriguez (A)

Department of Microbiology, New York University School of Medicine, New York, New York 10016, United States.

Albane Kessler (A)

GlaxoSmithKline, 28760 Tres Cantos, Spain.

Jonathan B Baell (JB)

School of Pharmaceutical Sciences, Nanjing Tech University, No. 30 South Puzhu Road, Nanjing 211816, China.
Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Australian Translational Medicinal Chemistry Facility (ATMCF), Monash University, Parkville, Victoria 3052, Australia.
Institute of Drug Discovery Technology (IDDT), Ningbo University, 818 Fenghua Road, Ningbo, Zhejiang 315211, China.
ORCID: 0000-0003-2114-8242

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Novel Diarylthioether Compounds as Agents for...
questionsmedicales.fr › Eucaryotes › Animaux › Novel Diarylthioether Compounds as Agents for...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Trypanocides › Novel Diarylthioether Compounds as Agents for...
questionsmedicales.fr › Infection › Maladies vectorielles › Maladie de Chagas › Novel Diarylthioether Compounds as Agents for...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Trypanosoma › Trypanosoma cruzi › Novel Diarylthioether Compounds as Agents for...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Novel Diarylthioether Compounds as Agents for...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Novel Diarylthioether Compounds as Agents for...