Reconstructed lung doses for the million person study cohort of 26,650 Tennessee Eastman corporation workers employed between 1942 and 1947.
dose reconstruction
epidemiology
inhalation
lungs
uranium
Journal
Journal of radiological protection : official journal of the Society for Radiological Protection
ISSN: 1361-6498
Titre abrégé: J Radiol Prot
Pays: England
ID NLM: 8809257
Informations de publication
Date de publication:
15 02 2023
15 02 2023
Historique:
received:
07
09
2022
accepted:
10
01
2023
pubmed:
11
1
2023
medline:
18
2
2023
entrez:
10
1
2023
Statut:
epublish
Résumé
Tennessee Eastman Corporation workers were exposed to uranium dust resulting in high-linear energy transfer (LET) irradiation to lung tissue. In this work, radiation lung doses were reconstructed for 26 650 men and women working at the plant between 1942 and 1947. Site air monitoring data of uranium concentrations and payroll records were used to determine the daily inhaled activities and annualized lung doses. Variations in the activity median aerodynamic diameter of the uranium dust, the solubility of particulate matter in the lungs and the sex-specific breathing rate were investigated as part of a sensitivity analysis. Male and female mean lung doses of 18.9 and 32.7 mGy, respectively, from high-LET alpha irradiation, and there was general agreement with evaluations from previously published epidemiological studies. Annual lung dose estimates and sensitivity analysis for the 26 650 workers in the TEC cohort have been archived on the United States Department of Energy Comprehensive Epidemiologic Data Resource.
Identifiants
pubmed: 36626823
doi: 10.1088/1361-6498/acb1be
pmc: PMC9930615
doi:
Substances chimiques
Uranium
4OC371KSTK
Dust
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCEH CDC HHS
ID : UE1 EH000989
Pays : United States
Informations de copyright
Creative Commons Attribution license.
Références
Health Phys. 2008 Jul;95(1):26-35
pubmed: 18545027
HASL Rep. 1959 Sep;58:103-14
pubmed: 14417405
Am J Ind Med. 1996 Feb;29(2):131-41
pubmed: 8821356
Ann ICRP. 2008;38(3):7-96
pubmed: 19285593
Radiat Res. 2020 Sep 16;194(3):259-276
pubmed: 32942303
Ann ICRP. 2017 Dec;46(3-4):1-486
pubmed: 29380630
Radiat Prot Dosimetry. 2003;105(1-4):175-8
pubmed: 14526952
AMA Arch Ind Health. 1956 Jul;14(1):12-22
pubmed: 13325976
Ann ICRP. 2007;37(2-4):1-332
pubmed: 18082557
Epidemiology. 1995 Jul;6(4):370-5
pubmed: 7548343
J Occup Med. 1987 Jul;29(7):601-4
pubmed: 3612338
Health Phys. 2019 Feb;116(2):235-246
pubmed: 30585971
Ann ICRP. 1994;24(1-3):1-482
pubmed: 7726471
Health Phys. 2001 Oct;81(4):378-94
pubmed: 11569633
Int J Radiat Biol. 2022;98(4):795-821
pubmed: 34669549
Int J Radiat Biol. 2023;99(2):208-228
pubmed: 35758985
Environ Res. 1982 Aug;28(2):313-28
pubmed: 7117220
J Occup Med. 1981 Mar;23(3):169-78
pubmed: 6985520
Int J Radiat Biol. 2003 Jan;79(1):1-13
pubmed: 12556326
Health Phys. 2002 Mar;82(3):279-89
pubmed: 11845831