Potential role of volatile organic compound breath testing in the Australasian colorectal cancer pathway.
breath test
cancer diagnosis
colorectal cancer
volatile organic compound
volatolomic
Journal
ANZ journal of surgery
ISSN: 1445-2197
Titre abrégé: ANZ J Surg
Pays: Australia
ID NLM: 101086634
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
revised:
07
11
2022
received:
19
06
2022
accepted:
27
11
2022
medline:
26
5
2023
pubmed:
12
1
2023
entrez:
11
1
2023
Statut:
ppublish
Résumé
With colonoscopy resources under pressure and inequitable participation rates in our screening programmes, there is an urgent need to consider trialling new testing technology for the detection of colorectal cancer (CRC) in Australasia. Research has shown that volatile organic compounds (VOCs) emitted from the human body can act as biomarkers for CRC, indicating high sensitivity and specificity for early and late-stage CRC and for adenomatous polyps. Breath-based VOC testing shows promise due to acceptability and ease of sampling via simple hand-held devices. Analysis can occur via mass spectrometry, or via 'e-nose' or sensor techniques. This review summarizes the current state of knowledge in using VOC-based testing for CRC. Adoption of this technique has the potential to improve CRC survival, reduce incidence and reduce colonoscopy burden in Australasia, and positively impact on ethnic disparities in cancer outcomes. Future multicentre trials should be conducted using standardized processes and protocols. This will ensure accuracy and reproducibility under different environmental and physiological conditions, and for different ethnic groups. Studies should be explicitly targeted to various points along the CRC patient pathway.
Substances chimiques
Volatile Organic Compounds
0
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1159-1161Subventions
Organisme : University of Otago Wellington PhD scholarship
Informations de copyright
© 2023 The Authors. ANZ Journal of Surgery published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Surgeons.
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