Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22.

Animals Mice Endothelial Cells / metabolism Interleukins / metabolism Liver Neoplasms / pathology Mice, Inbred C57BL Natural Killer T-Cells / metabolism Colorectal Neoplasms / metabolism Interleukin-22
ANPEP IL-22 cancer cell extravasation endothelial cells extravasation metastasis metastasis formation tissue resident cells

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
10 01 2023
Historique:
received: 22 08 2022
revised: 09 09 2022
accepted: 14 12 2022
entrez: 11 1 2023
pubmed: 12 1 2023
medline: 14 1 2023
Statut: ppublish

Résumé

During metastasis, cancer cells invade, intravasate, enter the circulation, extravasate, and colonize target organs. Here, we examined the role of interleukin (IL)-22 in metastasis. Immune cell-derived IL-22 acts on epithelial tissues, promoting regeneration and healing upon tissue damage, but it is also associated with malignancy. Il22-deficient mice and mice treated with an IL-22 antibody were protected from colon-cancer-derived liver and lung metastasis formation, while overexpression of IL-22 promoted metastasis. Mechanistically, IL-22 acted on endothelial cells, promoting endothelial permeability and cancer cell transmigration via induction of endothelial aminopeptidase N. Multi-parameter flow cytometry and single-cell sequencing of immune cells isolated during cancer cell extravasation into the liver revealed iNKT17 cells as source of IL-22. iNKT-cell-deficient mice exhibited reduced metastases, which was reversed by injection of wild type, but not Il22-deficient, invariant natural killer T (iNKT) cells. IL-22-producing iNKT cells promoting metastasis were tissue resident, as demonstrated by parabiosis. Thus, IL-22 may present a therapeutic target for prevention of metastasis.

Identifiants

DOI: 10.1016/j.immuni.2022.12.014 PMID: 36630911 PMC: PMC9839362
pubmed: 36630911
pii: S1074-7613(22)00650-1
doi: 10.1016/j.immuni.2022.12.014
pmc: PMC9839362
pii:
doi:

Substances chimiques

Interleukins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

125-142.e12

Subventions

Organisme : Howard Hughes Medical Institute
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests S.K. declares honoraria from GSK, BMS, Novartis, and TCR2, Inc.; license fees from TCR2, Inc. and Carina Biotech; and research support from TCR2, Inc., Plectonic GmbH, Tabby Therapeutics, and Arcus Biosciences.

Références

PLoS Biol. 2005 Apr;3(4):e113
pubmed: 15799695
Cell Immunol. 2009;254(2):81-4
pubmed: 19010461
J Thorac Cardiovasc Surg. 2009 Feb;137(2):486-91
pubmed: 19185174
Mol Ther. 2008 Apr;16(4):698-706
pubmed: 18362927
Mol Cancer. 2014 Nov 05;13:244
pubmed: 25373310
Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1637-42
pubmed: 22307623
J Clin Invest. 2009 Dec;119(12):3573-85
pubmed: 19920355
J Clin Invest. 2015 Dec;125(12):4529-43
pubmed: 26571401
Circulation. 2020 Nov 10;142(19):1848-1862
pubmed: 32929989
Histochem Cell Biol. 2011 May;135(5):499-512
pubmed: 21544708
Nat Commun. 2020 Sep 8;11(1):4457
pubmed: 32901017
Nat Commun. 2020 May 25;11(1):2608
pubmed: 32451418
Science. 2018 May 25;360(6391):
pubmed: 29798856
Sci Rep. 2016 Mar 24;6:23682
pubmed: 27009467
Mucosal Immunol. 2018 Jan;11(1):131-143
pubmed: 28401935
Cancer Res. 2018 Jun 15;78(12):3220-3232
pubmed: 29674477
J Am Acad Dermatol. 2018 May;78(5):872-881.e6
pubmed: 29353025
Cancer Med. 2020 Jan;9(1):361-373
pubmed: 31693304
Front Immunol. 2019 Jun 06;10:1126
pubmed: 31244823
J Immunol. 2014 Sep 1;193(5):2512-8
pubmed: 25063867
Nat Biotechnol. 2014 Apr;32(4):364-72
pubmed: 24633240
Front Oncol. 2019 Oct 04;9:1002
pubmed: 31637216
Science. 2016 Oct 21;354(6310):358-362
pubmed: 27846573
Clin Cancer Res. 2020 Aug 15;26(16):4313-4325
pubmed: 32430479
Nature. 2015 Dec 24;528(7583):560-564
pubmed: 26649819
Nat Immunol. 2010 Mar;11(3):197-206
pubmed: 20139988
Nat Med. 2018 Jul;24(7):986-993
pubmed: 29942092
Cell. 2019 Aug 22;178(5):1176-1188.e15
pubmed: 31442406
J Exp Med. 2011 Jun 6;208(6):1179-88
pubmed: 21624939
J Exp Med. 2011 May 9;208(5):1027-40
pubmed: 21518800
Cancer Immunol Res. 2018 Jul;6(7):788-797
pubmed: 29764837
BMC Cancer. 2013 Feb 05;13:59
pubmed: 23379788
Genome Biol. 2019 Dec 23;20(1):296
pubmed: 31870423
Dev Dyn. 2006 Mar;235(3):759-67
pubmed: 16450386
Immunol Rev. 2013 Mar;252(1):116-32
pubmed: 23405899
Gastroenterology. 2017 Mar;152(4):867-879
pubmed: 27889570
Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1565-70
pubmed: 20080688
Biomed Pharmacother. 2018 Jul;103:1101-1106
pubmed: 29710675
Nature. 2019 Feb;566(7743):249-253
pubmed: 30700914
Annu Rev Immunol. 2014;32:323-66
pubmed: 24499274
Nature. 2012 Nov 8;491(7423):259-63
pubmed: 23075849
Nat Immunol. 2005 Sep;6(9):895-901
pubmed: 16116469
PLoS One. 2014 Sep 16;9(9):e106921
pubmed: 25226518
J Clin Invest. 2017 Nov 1;127(11):4031-4041
pubmed: 28945199
Immunity. 2014 May 15;40(5):772-784
pubmed: 24816405
J Exp Med. 2019 Jan 7;216(1):133-151
pubmed: 30518599
J Cell Sci. 2010 Jul 1;123(Pt 13):2332-41
pubmed: 20530574
Nat Biotechnol. 2018 Jun;36(5):411-420
pubmed: 29608179
Ann Surg Oncol. 2014 Jan;21(1):125-32
pubmed: 24132627
Nat Rev Immunol. 2020 Aug;20(8):483-497
pubmed: 32024984
Immunity. 2016 Mar 15;44(3):698-711
pubmed: 26982367
Carcinogenesis. 2010 May;31(5):946-52
pubmed: 20176656
Nature. 2019 Jan;565(7739):366-371
pubmed: 30598548
Cancer Cell. 2021 May 10;39(5):708-724.e11
pubmed: 33798472
Nature. 2015 Jun 18;522(7556):345-348
pubmed: 25822788
Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20717-22
pubmed: 24297924
EMBO Mol Med. 2017 May;9(5):672-686
pubmed: 28341702
Signal Transduct Target Ther. 2020 Mar 12;5(1):28
pubmed: 32296047
J Vis Exp. 2014 Sep 27;(91):51677
pubmed: 25285458
Nature. 2017 Nov 2;551(7678):110-114
pubmed: 29072292
Nature. 2011 Jun 08;475(7355):222-5
pubmed: 21654748
J Exp Med. 2013 May 6;210(5):917-31
pubmed: 23589566
Clin Immunol. 2013 Apr;147(1):38-39
pubmed: 23501837
Immunity. 2013 Oct 17;39(4):782-95
pubmed: 24138885
Hepatology. 2011 Sep 2;54(3):900-9
pubmed: 21674558
Cell. 2019 Jun 13;177(7):1888-1902.e21
pubmed: 31178118
J Clin Invest. 2015 Jun;125(6):2317-34
pubmed: 25915587
J Biol Chem. 2012 Mar 16;287(12):8816-29
pubmed: 22294696
J Immunol. 2017 Dec 15;199(12):4078-4090
pubmed: 29109123
Sci Immunol. 2019 Apr 5;4(34):
pubmed: 30952804
Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12994-12999
pubmed: 29150554
Immunity. 2016 Oct 18;45(4):889-902
pubmed: 27692609
Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5126-31
pubmed: 15795373
Immunity. 2011 Apr 22;34(4):554-65
pubmed: 21511184
Nature. 2011 Jul 17;475(7357):514-8
pubmed: 21765430
Cancer Discov. 2020 Jan;10(1):124-141
pubmed: 31826876

Auteurs

Anastasios D Giannou (AD)

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. Electronic address: a.giannou@uke.de.

Jan Kempski (J)

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Ahmad Mustafa Shiri (AM)

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Jöran Lücke (J)

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Tao Zhang (T)

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Lilan Zhao (L)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Dimitra E Zazara (DE)

Division for Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; University Children's Hospital, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Filippo Cortesi (F)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Kristoffer Riecken (K)

Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Maria Carolina Amezcua Vesely (MC)

Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.

Jun Siong Low (JS)

Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.

Hao Xu (H)

Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.

Eleanna Kaffe (E)

Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.

Laura Garcia-Perez (L)

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Theodora Agalioti (T)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Yoshito Yamada (Y)

Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Japan; Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.

Wolfgang Jungraithmayr (W)

Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland; Department of Thoracic Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Ehud Zigmond (E)

The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; The Research Center for Digestive Tract and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Karl-Frederick Karstens (KF)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Babett Steglich (B)

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Jonas Wagner (J)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Leonie Konczalla (L)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Antonella Carambia (A)

I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.

Kornelius Schulze (K)

I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.

Johann von Felden (J)

I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.

Peter May (P)

Division of Clinical Pharmacology, Department of Medicine IV, Klinikum der Universität München, Munich, Germany.

Daria Briukhovetska (D)

Division of Clinical Pharmacology, Department of Medicine IV, Klinikum der Universität München, Munich, Germany.

Tanja Bedke (T)

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Leonie Brockmann (L)

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Sarah Starzonek (S)

Institute of Anatomy and Experimental Morphology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Tobias Lange (T)

Institute of Anatomy and Experimental Morphology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Institute of Anatomy I, University Hospital Jena, 07743 Jena, Germany.

Claudia Koch (C)

Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Sabine Riethdorf (S)

Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Penelope Pelczar (P)

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Marius Böttcher (M)

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Morsal Sabihi (M)

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Francis J Huber (FJ)

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Matthias Reeh (M)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Julia Kristin Grass (JK)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Ramez Wahib (R)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Hannes Seese (H)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Björn-Ole Stüben (BO)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Mohammad Fard-Aghaie (M)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Anna Duprée (A)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Pasquale Scognamiglio (P)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Gabriel Plitzko (G)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Jan Meiners (J)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Shiwa Soukou (S)

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Agnes Wittek (A)

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Caroline Manthey (C)

I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.

Ioannis C Maroulis (IC)

Department of Surgery, University of Patras Medical School, Patras, Greece.

Petra C Arck (PC)

Division for Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Daniel Perez (D)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Bin Gao (B)

Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.

Sotirios G Zarogiannis (SG)

Department of Physiology, Faculty of Medicine, University of Thessaly, BIOPOLIS, Larissa, Greece; Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Till Strowig (T)

Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, 38124 Braunschweig, Germany.

Renata Pasqualini (R)

Rutgers Cancer Institute of New Jersey and Division of Cancer Biology, Department of Radiation Oncology, Rutgers New Jersey Medical School, Newark, NJ, USA.

Wadih Arap (W)

Rutgers Cancer Institute of New Jersey and Division of Hematology/Oncology, Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.

Javier Suárez Gosálvez (JS)

Division of Clinical Pharmacology, Department of Medicine IV, Klinikum der Universität München, Munich, Germany.

Sebastian Kobold (S)

Division of Clinical Pharmacology, Department of Medicine IV, Klinikum der Universität München, Munich, Germany; German Center for Translational Cancer Research (DKTK), Partner Site Munich, Munich, Germany; Einheit für Klinische Pharmakologie (EKLiP), Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Neuherberg, Germany.

Immo Prinz (I)

Institute of Immunology, Hannover Medical School, Hannover, Germany; Institute of Systems Immunology, Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Andreas H Guse (AH)

The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Michael Tachezy (M)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Tarik Ghadban (T)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Asmus Heumann (A)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Jun Li (J)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Nathaniel Melling (N)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Oliver Mann (O)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Jakob R Izbicki (JR)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Klaus Pantel (K)

Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Udo Schumacher (U)

Institute of Anatomy and Experimental Morphology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Medical School Berlin, 10117 Berlin, Germany.

Ansgar W Lohse (AW)

I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.

Richard A Flavell (RA)

Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.

Nicola Gagliani (N)

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Samuel Huber (S)

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. Electronic address: shuber@uke.de.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Tissue resident iNKT17 cells facilitate cancer...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Tissue resident iNKT17 cells facilitate cancer...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Tissue resident iNKT17 cells facilitate cancer...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Tissue resident iNKT17 cells facilitate cancer...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Tissue resident iNKT17 cells facilitate cancer...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Tissue resident iNKT17 cells facilitate cancer...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Cellules T tueuses naturelles › Tissue resident iNKT17 cells facilitate cancer...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Tissue resident iNKT17 cells facilitate cancer...