An atlas of substrate specificities for the human serine/threonine kinome.

Humans Phosphorylation Protein Serine-Threonine Kinases / metabolism Serine / metabolism Substrate Specificity Threonine / metabolism Proteome / chemistry Datasets as Topic Phosphoproteins / chemistry Cell Line Phosphoserine / metabolism Phosphothreonine / metabolism

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
01 2023
Historique:
received: 01 05 2022
accepted: 17 11 2022
pubmed: 12 1 2023
medline: 28 1 2023
entrez: 11 1 2023
Statut: ppublish

Résumé

Protein phosphorylation is one of the most widespread post-translational modifications in biology

Identifiants

DOI: 10.1038/s41586-022-05575-3 PMID: 36631611 PMC: PMC9876800
pubmed: 36631611
doi: 10.1038/s41586-022-05575-3
pii: 10.1038/s41586-022-05575-3
pmc: PMC9876800
doi:

Substances chimiques

Protein Serine-Threonine Kinases EC 2.7.11.1
Serine 452VLY9402
Threonine 2ZD004190S
Proteome 0
Phosphoproteins 0
Phosphoserine 17885-08-4
Phosphothreonine 1114-81-4

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

759-766

Subventions

Organisme : NCI NIH HHS
ID : P01 CA120964
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA117969
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM104047
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014051
Pays : United States
Organisme : NIEHS NIH HHS
ID : R35 ES028374
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA203702
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK116204
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA226898
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM139550
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197588
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2023. The Author(s).

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Auteurs

Jared L Johnson (JL)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0003-1802-6527

Tomer M Yaron (TM)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Tri-Institutional PhD Program in Computational Biology & Medicine, Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center and The Rockefeller University, New York, NY, USA.
ORCID: 0000-0001-6574-7314

Emily M Huntsman (EM)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Alexander Kerelsky (A)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.

Junho Song (J)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0003-0898-8749

Amit Regev (A)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Ting-Yu Lin (TY)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Weill Cornell Graduate School of Medical Sciences, Cell and Developmental Biology Program, New York, NY, USA.

Katarina Liberatore (K)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Daniel M Cizin (DM)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Benjamin M Cohen (BM)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Neil Vasan (N)

Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.
Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.

Yilun Ma (Y)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Konstantin Krismer (K)

Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Center for Precision Cancer Medicine, Koch Institute for Integrative Cancer Biology, Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
ORCID: 0000-0001-8994-3416

Jaylissa Torres Robles (JT)

Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA.
Department of Chemistry, Yale University, New Haven, CT, USA.
ORCID: 0000-0002-7353-0518

Bert van de Kooij (B)

Center for Precision Cancer Medicine, Koch Institute for Integrative Cancer Biology, Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

Anne E van Vlimmeren (AE)

Center for Precision Cancer Medicine, Koch Institute for Integrative Cancer Biology, Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
ORCID: 0000-0003-0379-4945

Nicole Andrée-Busch (N)

Institute of Genetics, Technische Universität Braunschweig, Braunschweig, Germany.

Norbert F Käufer (NF)

Institute of Genetics, Technische Universität Braunschweig, Braunschweig, Germany.

Maxim V Dorovkov (MV)

Department of Pharmacology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.
ORCID: 0000-0002-1128-1480

Alexey G Ryazanov (AG)

Department of Pharmacology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.

Yuichiro Takagi (Y)

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
ORCID: 0000-0002-0988-6798

Edward R Kastenhuber (ER)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-1872-212X

Marcus D Goncalves (MD)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Division of Endocrinology, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-0784-9248

Benjamin D Hopkins (BD)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Olivier Elemento (O)

Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.

Dylan J Taatjes (DJ)

Department of Biochemistry, University of Colorado, Boulder, CO, USA.
ORCID: 0000-0003-4444-5688

Alexandre Maucuer (A)

SABNP, Univ Evry, INSERM U1204, Université Paris-Saclay, Evry, France.
ORCID: 0000-0003-2947-6654

Akio Yamashita (A)

Department of Investigative Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara-cho, Japan.

Alexei Degterev (A)

Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA.
ORCID: 0000-0002-8240-7132

Mohamed Uduman (M)

Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA.

Jingyi Lu (J)

Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA.

Sean D Landry (SD)

Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA.
ORCID: 0000-0002-6242-2300

Bin Zhang (B)

Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA.

Ian Cossentino (I)

Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA.
ORCID: 0000-0002-1179-2045

Rune Linding (R)

Rewire Tx, Humboldt-Universität zu Berlin, Berlin, Germany.

John Blenis (J)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.
Department of Biochemistry, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0003-3622-2337

Peter V Hornbeck (PV)

Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA.

Benjamin E Turk (BE)

Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA. ben.turk@yale.edu.
ORCID: 0000-0001-9275-4069

Michael B Yaffe (MB)

Center for Precision Cancer Medicine, Koch Institute for Integrative Cancer Biology, Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. myaffe@mit.edu.
Divisions of Acute Care Surgery, Trauma, and Surgical Critical Care, and Surgical Oncology, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. myaffe@mit.edu.
Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. myaffe@mit.edu.
ORCID: 0000-0002-9547-3251

Lewis C Cantley (LC)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. LCantley@med.cornell.edu.
Department of Medicine, Weill Cornell Medicine, New York, NY, USA. LCantley@med.cornell.edu.
ORCID: 0000-0002-1298-7653

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › An atlas of substrate specificities for the...
questionsmedicales.fr › Métabolisme › Phosphorylation › An atlas of substrate specificities for the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › An atlas of substrate specificities for the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés neutres › Sérine › An atlas of substrate specificities for the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Spécificité du substrat › An atlas of substrate specificities for the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés neutres › Thréonine › An atlas of substrate specificities for the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéome › An atlas of substrate specificities for the...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Jeux de données comme sujet › An atlas of substrate specificities for the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › An atlas of substrate specificities for the...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › An atlas of substrate specificities for the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides phosphoaminés › Phosphosérine › An atlas of substrate specificities for the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides phosphoaminés › Phosphothréonine › An atlas of substrate specificities for the...