Pyroptosis, inflammasome, and gasdermins in tumor immunity.
Gasdermin A
anti-tumor immunity
gasdermin B
gasdermin C
gasdermin D
gasdermin E
inflammasome
pyroptosis
Journal
Innate immunity
ISSN: 1753-4267
Titre abrégé: Innate Immun
Pays: United States
ID NLM: 101469670
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
medline:
8
5
2023
pubmed:
13
1
2023
entrez:
12
1
2023
Statut:
ppublish
Résumé
The gasdermins (GSDM), a family of pore-forming proteins, consist of gasdermin A (GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), gasdermin D (GSDMD), gasdermin E (GSDME) and DFNB59 (Pejvakin (PJVK)) in humans. These proteins play an important role in pyroptosis. Among them, GSDMD is the most extensively studied protein and is identified as the executioner of pyroptosis. Other family members have also been implicated in certain cancers. As a unique form of programmed cell death, pyroptosis is closely related to tumor progression, and the inflammasome, an innate immune mechanism that induces inflammation and pyroptosis. In this review, we explore the current developments of pyroptosis, the inflammasome, and especially we review the gasdermin family members and their role in inducing pyroptosis and the possible therapeutic values in antitumor effects.
Identifiants
pubmed: 36632024
doi: 10.1177/17534259221143216
pmc: PMC10164276
doi:
Substances chimiques
Inflammasomes
0
Gasdermins
0
Neoplasm Proteins
0
GSDMC protein, human
0
Biomarkers, Tumor
0
Pore Forming Cytotoxic Proteins
0
GSDMA protein, human
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3-13Références
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