Meta-topologies define distinct anatomical classes of brain tumours linked to histology and survival.

anatomy artificial intelligence glioma machine learning metastases

Journal

Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125

Informations de publication

Date de publication:
2023
Historique:
received: 20 04 2022
revised: 06 08 2022
accepted: 20 12 2022
entrez: 12 1 2023
pubmed: 13 1 2023
medline: 13 1 2023
Statut: epublish

Résumé

The current World Health Organization classification integrates histological and molecular features of brain tumours. The aim of this study was to identify generalizable topological patterns with the potential to add an anatomical dimension to the classification of brain tumours. We applied non-negative matrix factorization as an unsupervised pattern discovery strategy to the fine-grained topographic tumour profiles of 936 patients with neuroepithelial tumours and brain metastases. From the anatomical features alone, this machine learning algorithm enabled the extraction of latent topological tumour patterns, termed

Identifiants

pubmed: 36632188
doi: 10.1093/braincomms/fcac336
pii: fcac336
pmc: PMC9830987
doi:

Types de publication

Journal Article

Langues

eng

Pagination

fcac336

Informations de copyright

© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.

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Auteurs

Julius M Kernbach (JM)

Neurosurgical Artificial Intelligence Laboratory Aachen (NAILA), RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany.
Department of Neurosurgery, Faculty of Medicine, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.
Center for Integrated Oncology, Düsseldorf (CIO ABCD), Universities Aachen, Bonn, Cologne, Germany.

Daniel Delev (D)

Neurosurgical Artificial Intelligence Laboratory Aachen (NAILA), RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany.
Department of Neurosurgery, Faculty of Medicine, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.
Center for Integrated Oncology, Düsseldorf (CIO ABCD), Universities Aachen, Bonn, Cologne, Germany.

Georg Neuloh (G)

Department of Neurosurgery, Faculty of Medicine, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.
Center for Integrated Oncology, Düsseldorf (CIO ABCD), Universities Aachen, Bonn, Cologne, Germany.

Hans Clusmann (H)

Department of Neurosurgery, Faculty of Medicine, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.
Center for Integrated Oncology, Düsseldorf (CIO ABCD), Universities Aachen, Bonn, Cologne, Germany.

Danilo Bzdok (D)

Department of Biomedical Engineering, McConnell Brain Imaging Centre, Montreal Neurological Institute, Faculty of Medicine, School of Computer Science, McGill University, 845 Sherbrooke St W, Montreal, Quebec H3A 0G4, Canada.
Mila-Quebec Artificial Intelligence Institute, 6666 Rue Saint-Urbain, Montreal, Quebec H2S 3H1, Canada.

Simon B Eickhoff (SB)

Institute of Neuroscience and Medicine (INM-7), Research Centre Jülich, Wilhelm Johnen Strasse, 52428 Jülich, Germany.
Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany.

Victor E Staartjes (VE)

Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland.

Flavio Vasella (F)

Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland.

Michael Weller (M)

Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland.

Luca Regli (L)

Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland.

Carlo Serra (C)

Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland.

Niklaus Krayenbühl (N)

Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland.
Division of Pediatric Neurosurgery, University Children's Hospital, Steinwiesstrasse 75, 8032 Zurich, Switzerland.

Kevin Akeret (K)

Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland.

Classifications MeSH