Spatial orientation - a stable marker for vascular cognitive impairment?
COT, Clock Orientation Test
Egocentric orientation
SHQ, Sea Hero Quest
Spatial navigation
VST, Virtual Supermarket Test
Vascular cognitive impairment
Vascular dementia
Vascular dementia case report
WMH, white matter hyperintensities
Journal
Cerebral circulation - cognition and behavior
ISSN: 2666-2450
Titre abrégé: Cereb Circ Cogn Behav
Pays: Netherlands
ID NLM: 101774849
Informations de publication
Date de publication:
2023
2023
Historique:
received:
17
10
2022
revised:
06
12
2022
accepted:
14
12
2022
entrez:
12
1
2023
pubmed:
13
1
2023
medline:
13
1
2023
Statut:
epublish
Résumé
Vascular cognitive impairment (VCI) is the second most prevalent form of dementia, but little is known about the early cognitive and neuroimaging markers. Spatial navigation deficits are an emerging marker for Alzheimer's disease (AD), yet less is known about spatial orientation deficits sensitive to VCI. This case report follows up on the first VCI patient identified to have an egocentric orientation deficit. The study aimed to examine the patient's spatial deficits three years on and gain insights from the addition of the patient's MRI brain scan. A battery of spatial navigation tasks were administered following neuropsychological assessment. Results continue to show spatial orientation deficits. Critically, these changes appear stable and are sensitive to novel spatial tests. Whereas conventional screening tools demonstrate patient recovery. MRI DTI analysis indicates a non-significant trend towards loss of structural integrity to the posterior tracts of the longitudinal superior fasciculus (SLF), while the medial temporal lobe, typically implicated in spatial navigation, is unaffected. This finding potentially reflects reduced network connectivity in posterior to anterior white matter tracts co-existing with spatial orientation deficits. Findings have clinical utility and show spatial orientation as a potential sensitive cognitive marker for VCI.
Identifiants
pubmed: 36632487
doi: 10.1016/j.cccb.2022.100155
pii: S2666-2450(22)00120-9
pmc: PMC9826950
doi:
Types de publication
Case Reports
Langues
eng
Pagination
100155Informations de copyright
Crown Copyright © 2022 Published by Elsevier B.V.
Déclaration de conflit d'intérêts
All of the contributing authors have no competing interests.
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