Crystal structures of 'ALternative Isoinformational ENgineered' DNA in B-form.

Mice Animals DNA / chemistry Oligonucleotides / chemistry
ALIEN DNA B-form DNA crystal structures unnatural DNA xNA

Journal

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
ISSN: 1471-2970
Titre abrégé: Philos Trans R Soc Lond B Biol Sci
Pays: England
ID NLM: 7503623

Informations de publication

Date de publication:
27 02 2023
Historique:
entrez: 12 1 2023
pubmed: 13 1 2023
medline: 14 1 2023
Statut: ppublish

Résumé

The first structural model of duplex DNA reported in 1953 by Watson & Crick presented the double helix in B-form, the form that genomic DNA exists in much of the time. Thus, artificial DNA seeking to mimic the properties of natural DNA should also be able to adopt B-form. Using a host-guest system in which Moloney murine leukemia virus reverse transcriptase serves as the host and DNA as the guests, we determined high-resolution crystal structures of three complexes including 5'-CTT

Identifiants

DOI: 10.1098/rstb.2022.0028 PMID: 36633282 PMC: PMC9835606
pubmed: 36633282
doi: 10.1098/rstb.2022.0028
pmc: PMC9835606
doi:

Substances chimiques

DNA 9007-49-2
Oligonucleotides 0

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

20220028

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Auteurs

Madhura S Shukla (MS)

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Shuichi Hoshika (S)

Foundation for Applied Molecular Evolution, 13709 Progress Boulevard, no. 7, Alachua, FL 32615, USA.

Steven A Benner (SA)

Foundation for Applied Molecular Evolution, 13709 Progress Boulevard, no. 7, Alachua, FL 32615, USA.
ORCID: 0000-0002-3318-9917

Millie M Georgiadis (MM)

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
ORCID: 0000-0003-2976-4576

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Crystal structures of 'ALternative...
questionsmedicales.fr › Eucaryotes › Animaux › Crystal structures of 'ALternative...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Crystal structures of 'ALternative...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Crystal structures of 'ALternative...