Circulating Copper and Liver Cancer.
Circulating copper
Liver cancer
Mendelian randomization analysis
Meta-analysis
Journal
Biological trace element research
ISSN: 1559-0720
Titre abrégé: Biol Trace Elem Res
Pays: United States
ID NLM: 7911509
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
01
12
2022
accepted:
02
01
2023
medline:
11
8
2023
pubmed:
13
1
2023
entrez:
12
1
2023
Statut:
ppublish
Résumé
The association between circulating copper and the risk of liver cancer has been investigated by previous studies, while the findings were inconsistent. Thus, we aimed to evaluate the association between circulating copper and liver cancer by using meta-analysis and Mendelian randomization (MR). For meta-analysis, PubMed and Web of Science were searched to identify eligible studies published before April 4, 2022. Standardized mean difference (SMD) with 95% confidence interval (CI) in circulating copper level between liver cancer patients and controls were pooled. Furthermore, we selected genetic instruments for circulating copper from a genome-wide association study (GWAS) to conduct MR analysis. The summary statistics related to liver cancer were obtained from two large independent cohorts, UKBB and FinnGen, respectively. MR analysis was performed mainly by inverse-variance weighted (IVW) approach, followed by maximum-likelihood method as sensitivity analysis. In meta-analysis of eight studies, circulating copper was found to be higher in liver cancer patients (SMD: 1.65; 95% CI: 0.65 to 2.65) with high heterogeneity (I
Identifiants
pubmed: 36633787
doi: 10.1007/s12011-023-03554-x
pii: 10.1007/s12011-023-03554-x
doi:
Substances chimiques
Copper
789U1901C5
Types de publication
Meta-Analysis
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4649-4656Subventions
Organisme : Natural Science Foundation of Zhejiang Province
ID : LQ20H260008
Organisme : Zhejiang Chinese Medical University Foundation
ID : 2020ZG01
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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