Pre- and Post-treatment Serum BAFF Levels and BAFF Gene Polymorphisms in Patients with Graves' Disease.
BAFF
Graves’s disease
autoantibody
dynamics
polymorphism
Journal
Endocrine research
ISSN: 1532-4206
Titre abrégé: Endocr Res
Pays: England
ID NLM: 8408548
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
pubmed:
14
1
2023
medline:
25
2
2023
entrez:
13
1
2023
Statut:
ppublish
Résumé
B cell activating factor (BAFF), a crucial factor for B cell survival and differentiation, has been linked to several autoimmune conditions. The aim of this study was to evaluate the association of BAFF gene's polymorphisms with its serum levels and to assess their effect on Graves' disease (GD) susceptibility and presentation. Sixty-two GD patients and 152 healthy controls have been enrolled to investigate BAFF rs9514827 (-2841 T/C), rs1041569 (-2701 T/A) and rs9514828 (-871 C/T) gene's polymorphism by PCR-RFLP and serum BAFF level's kinetics under medical treatment by ELISA. Median serum BAFF level at baseline was significantly higher in GD patients (841.7 pg/ml [685.23-1058.32]) comparatively to controls (495.75 pg/ml [383.17-595.7]), Serum BAFF level is significantly increased in GD especially in smoking patients. rs9514828 - 871*T allele might be a susceptibility variant for GD.
Sections du résumé
BACKGROUND
UNASSIGNED
B cell activating factor (BAFF), a crucial factor for B cell survival and differentiation, has been linked to several autoimmune conditions. The aim of this study was to evaluate the association of BAFF gene's polymorphisms with its serum levels and to assess their effect on Graves' disease (GD) susceptibility and presentation.
METHODS
UNASSIGNED
Sixty-two GD patients and 152 healthy controls have been enrolled to investigate BAFF rs9514827 (-2841 T/C), rs1041569 (-2701 T/A) and rs9514828 (-871 C/T) gene's polymorphism by PCR-RFLP and serum BAFF level's kinetics under medical treatment by ELISA.
RESULTS
UNASSIGNED
Median serum BAFF level at baseline was significantly higher in GD patients (841.7 pg/ml [685.23-1058.32]) comparatively to controls (495.75 pg/ml [383.17-595.7]),
CONCLUSION
UNASSIGNED
Serum BAFF level is significantly increased in GD especially in smoking patients. rs9514828 - 871*T allele might be a susceptibility variant for GD.
Identifiants
pubmed: 36636836
doi: 10.1080/07435800.2023.2167087
doi:
Substances chimiques
B-Cell Activating Factor
0
E 25
27527-13-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM