This review investigates how point-of-care ultrasound (POCUS) allows individualised treatment based on the patient's clinical and physiological state. Serial examinations enable timely adjustments of interventions, potentially fewer side effects, and less need for x-ray examinations. One of the main barriers to POCUS is the lack of systematic training and quality control. The next step toward more widespread use of neonatal POCUS is systematic theoretical and practical training and implementing standardized examination protocols.