A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease.

Mice Animals Low Density Lipoprotein Receptor-Related Protein-6 / genetics Alzheimer Disease / genetics Wnt Signaling Pathway Synapses / metabolism Aging / genetics

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
13 01 2023
Historique:
entrez: 13 1 2023
pubmed: 14 1 2023
medline: 18 1 2023
Statut: ppublish

Résumé

Synapse loss strongly correlates with cognitive decline in Alzheimer's disease (AD), but the underlying mechanisms are poorly understood. Deficient Wnt signaling contributes to synapse dysfunction and loss in AD. Consistently, a variant of the

Identifiants

DOI: 10.1126/sciadv.abo7421 PMID: 36638182 PMC: PMC10624429
pubmed: 36638182
doi: 10.1126/sciadv.abo7421
pmc: PMC10624429
doi:

Substances chimiques

Low Density Lipoprotein Receptor-Related Protein-6 0
Lrp6 protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabo7421

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S012125/1
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Références

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Auteurs

Megan E Jones (ME)

Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.
ORCID: 0000-0002-8056-2016

Johanna Büchler (J)

Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.
ORCID: 0000-0001-9646-5985

Tom Dufor (T)

Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.
ORCID: 0000-0001-5804-5445

Ernest Palomer (E)

Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.
ORCID: 0000-0001-8629-2443

Samuel Teo (S)

Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.

Nuria Martin-Flores (N)

Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.
ORCID: 0000-0003-2537-751X

Katharina Boroviak (K)

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

Emmanouil Metzakopian (E)

UK Dementia Research Institute, Department of Clinical Neuroscience, University of Cambridge, Cambridge CB2 0AH, UK.

Alasdair Gibb (A)

Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
ORCID: 0000-0002-2145-1615

Patricia C Salinas (PC)

Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.
ORCID: 0000-0002-5748-083X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A genetic variant of the Wnt receptor LRP6...
questionsmedicales.fr › Eucaryotes › Animaux › A genetic variant of the Wnt receptor LRP6...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs Wnt › Protéine-6 apparentée au récepteur des LDL › A genetic variant of the Wnt receptor LRP6...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › A genetic variant of the Wnt receptor LRP6...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Voie de signalisation Wnt › A genetic variant of the Wnt receptor LRP6...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › A genetic variant of the Wnt receptor LRP6...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › A genetic variant of the Wnt receptor LRP6...