Circularized RNA as novel therapeutics in cancer.

Humans RNA / genetics RNA, Circular / genetics Neoplasms / genetics MicroRNAs / genetics RNA, Messenger / genetics RNA, Small Interfering
Cancer Circular RNA (circRNA) Engineered circRNA Protein synthesis Synthetic circRNA Therapeutic target

Journal

The international journal of biochemistry & cell biology
ISSN: 1878-5875
Titre abrégé: Int J Biochem Cell Biol
Pays: Netherlands
ID NLM: 9508482

Informations de publication

Date de publication:
03 2023
Historique:
received: 31 08 2022
revised: 22 12 2022
accepted: 07 01 2023
pubmed: 14 1 2023
medline: 8 2 2023
entrez: 13 1 2023
Statut: ppublish

Résumé

Circular RNAs (CircRNAs) regulate gene expression by functioning as microRNA sponges, regulating protein stability, and gilding proteins for gene transcription and translation. Also, limited circRNAs harbour protein-coding ability through cap-independent pathways. These molecular mechanisms of circRNAs contribute to their importance in several cellular processes. Particularly, the dysregulation of circRNAs also plays a critical role in disease development. Targeting disease-causing circRNAs by restoring their normal expression by gain-of-function or loss-of-function approach and regulating their molecular activities could be potential direction for the development of anti-cancer therapies. Furthermore, due to unique covalently closed circular structure, the superior stability of circRNAs also grants them as novel therapeutic tools replacing the therapeutic small interfering RNAs and messenger RNAs. Here, we will review the functional and molecular mechanisms of circRNAs in pathogenesis, the current methods for targeting the dysregulated circRNAs, and the potential of using synthetic circRNAs in disease treatment and prevention.

Identifiants

DOI: 10.1016/j.biocel.2023.106364 PMID: 36639095
pubmed: 36639095
pii: S1357-2725(23)00003-1
doi: 10.1016/j.biocel.2023.106364
pii:
doi:

Substances chimiques

RNA 63231-63-0
RNA, Circular 0
MicroRNAs 0
RNA, Messenger 0
RNA, Small Interfering 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

106364

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Conflicts of interest The authors have no conflict of interest to disclose.

Auteurs

Jessica Jazmin Peña-Paladines (JJ)

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.

Chi Hin Wong (CH)

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518087, China.

Yangchao Chen (Y)

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518087, China. Electronic address: yangchaochen@cuhk.edu.hk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Circularized RNA as novel therapeutics in cancer.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › Circularized RNA as novel therapeutics in cancer.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN circulaire › Circularized RNA as novel therapeutics in cancer.
questionsmedicales.fr › Tumeurs › Circularized RNA as novel therapeutics in cancer.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Circularized RNA as novel therapeutics in cancer.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Circularized RNA as novel therapeutics in cancer.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › Circularized RNA as novel therapeutics in cancer.