Axonal plasticity in response to active forces generated through magnetic nano-pulling.
CP: Cell biology
CP: Neuroscience
axon
force
local translation
magnetic nanoparticles
microtubules
outgrowth
remodeling
synapse
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
31 01 2023
31 01 2023
Historique:
received:
06
04
2022
revised:
16
11
2022
accepted:
12
12
2022
pubmed:
15
1
2023
medline:
7
2
2023
entrez:
14
1
2023
Statut:
ppublish
Résumé
Mechanical force is crucial in guiding axon outgrowth before and after synapse formation. This process is referred to as "stretch growth." However, how neurons transduce mechanical input into signaling pathways remains poorly understood. Another open question is how stretch growth is coupled in time with the intercalated addition of new mass along the entire axon. Here, we demonstrate that active mechanical force generated by magnetic nano-pulling induces remodeling of the axonal cytoskeleton. Specifically, the increase in the axonal density of microtubules induced by nano-pulling leads to an accumulation of organelles and signaling vesicles, which, in turn, promotes local translation by increasing the probability of assembly of the "translation factories." Modulation of axonal transport and local translation sustains enhanced axon outgrowth and synapse maturation.
Identifiants
pubmed: 36640304
pii: S2211-1247(22)01811-3
doi: 10.1016/j.celrep.2022.111912
pmc: PMC9902337
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111912Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
Références
J Neurobiol. 2004 Feb 5;58(2):207-16
pubmed: 14704953
Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7501-6
pubmed: 26034266
Nature. 2010 Nov 25;468(7323):576-9
pubmed: 21107429
Nat Commun. 2019 May 29;10(1):2360
pubmed: 31142740
Mol Metab. 2018 Jan;7:12-22
pubmed: 29157948
Cell. 1991 May 31;65(5):837-47
pubmed: 1710172
Elife. 2021 Sep 27;10:
pubmed: 34569932
Arch Biochem Biophys. 1998 Sep 15;357(2):299-309
pubmed: 9735171
J Cell Sci. 1996 Nov;109 ( Pt 11):2661-72
pubmed: 8937984
J Biol Chem. 1984 Apr 25;259(8):5301-5
pubmed: 6425287
Mol Biol Cell. 2017 Oct 15;28(21):2786-2801
pubmed: 28835377
Nat Rev Mol Cell Biol. 2009 May;10(5):332-43
pubmed: 19373241
Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14670-5
pubmed: 23964126
J Neurosci. 2016 Jan 20;36(3):979-87
pubmed: 26791225
Nanomedicine. 2014 Oct;10(7):1549-58
pubmed: 24407149
Nat Neurosci. 2006 Dec;9(12):1488-98
pubmed: 17115039
Front Mol Biosci. 2017 Feb 02;4:4
pubmed: 28210618
Sci Rep. 2020 Jul 14;10(1):11540
pubmed: 32665608
Nature. 1989 Jul 13;340(6229):159-62
pubmed: 2739738
iScience. 2022 Jan 25;25(2):103807
pubmed: 35198872
Front Mol Neurosci. 2021 Jun 14;14:697973
pubmed: 34194300
Invest Ophthalmol Vis Sci. 2014 Jun 06;55(7):4369-77
pubmed: 24906860
Dev Biol. 1984 Apr;102(2):379-89
pubmed: 6706005
Front Neuroanat. 2015 May 15;9:51
pubmed: 26029056
Biol Cell. 2018 Jun;110(6):125-136
pubmed: 29698566
Neuron. 1993 Jul;11(1):153-63
pubmed: 8393323
Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
J Neurosci. 2004 Dec 15;24(50):11368-80
pubmed: 15601943
Dev Neurobiol. 2010 Feb 15;70(3):135-49
pubmed: 19950193
Nat Commun. 2016 Oct 03;7:12557
pubmed: 27694937
Curr Biol. 2013 Mar 18;23(6):529-34
pubmed: 23453953
Nat Cell Biol. 2007 Jul;9(7):832-7
pubmed: 17572669
J Cell Biol. 2003 Sep 29;162(7):1317-28
pubmed: 14517209
Biophys J. 2012 Aug 8;103(3):492-500
pubmed: 22947865
Mol Biol Cell. 2020 May 15;31(11):1154-1166
pubmed: 32213119
Mol Biol Cell. 1997 Jun;8(6):973-85
pubmed: 9201709
Neuron. 2019 Jul 17;103(2):217-234.e4
pubmed: 31171447
Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19042-7
pubmed: 22065745
J Cell Sci. 1999 Feb;112 ( Pt 3):395-403
pubmed: 9885292
Curr Opin Struct Biol. 2019 Feb;54:152-160
pubmed: 30904821
Sci Adv. 2021 Sep 17;7(38):eabg4617
pubmed: 34533987
J Nanobiotechnology. 2020 Apr 25;18(1):64
pubmed: 32334582
Methods Mol Biol. 2018;1727:295-314
pubmed: 29222790
Nat Struct Mol Biol. 2019 Jul;26(7):557-566
pubmed: 31270476
J Biol Chem. 1993 Jan 15;268(2):1166-73
pubmed: 8419321
Mol Biol Cell. 2016 Feb 1;27(3):500-17
pubmed: 26631553
Lab Chip. 2017 Mar 14;17(6):1116-1127
pubmed: 28207921
Ultrason Sonochem. 2021 May;73:105494
pubmed: 33640571
J Neurosci. 2004 Sep 8;24(36):7978-83
pubmed: 15356212
Biophys J. 2018 Nov 6;115(9):1783-1795
pubmed: 30309611
J Neurosci. 2020 Jun 24;40(26):4997-5007
pubmed: 32444384
Cell. 2007 Nov 30;131(5):952-65
pubmed: 18045537
Neuron. 2017 Nov 1;96(3):638-650
pubmed: 29096077
Nature. 1963 Nov 16;200:675-6
pubmed: 14109947
J Neurosci. 1997 Dec 1;17(23):8955-63
pubmed: 9364043
J Cell Biol. 1984 Dec;99(6):2041-7
pubmed: 6389568
J Cell Biol. 2008 Feb 11;180(3):619-32
pubmed: 18268107
Cell Rep. 2019 Dec 10;29(11):3605-3619.e10
pubmed: 31825839
ACS Nano. 2016 Feb 23;10(2):2331-41
pubmed: 26805612
J Neurosci. 2001 Jul 15;21(14):5169-81
pubmed: 11438592
Sci Rep. 2020 Nov 25;10(1):20576
pubmed: 33239744
Front Neurosci. 2018 May 15;12:299
pubmed: 29867315
Stem Cell Reports. 2018 Dec 11;11(6):1565-1578
pubmed: 30540963
J Biol Chem. 2020 Dec 11;295(50):17138-17147
pubmed: 33020179
Elife. 2017 Jan 18;6:
pubmed: 28098556
Cytometry A. 2004 Apr;58(2):167-76
pubmed: 15057970
Dev Neurobiol. 2008 Oct;68(12):1363-77
pubmed: 18698606
Nat Methods. 2005 Aug;2(8):599-605
pubmed: 16094385
Eur J Neurosci. 2007 Dec;26(12):3429-36
pubmed: 18052981
Ann Biomed Eng. 2012 Jun;40(6):1268-76
pubmed: 22302320
Cell. 2019 Jan 10;176(1-2):56-72.e15
pubmed: 30612743
Nat Neurosci. 2005 Jan;8(1):43-50
pubmed: 15580270
J Cell Biol. 2003 May 26;161(4):737-47
pubmed: 12756235
J Vis Exp. 2010 Nov 16;(45):
pubmed: 21113117
Front Cell Neurosci. 2018 Nov 26;12:447
pubmed: 30534055
Lab Chip. 2017 Feb 28;17(5):842-854
pubmed: 28164203
Front Mol Neurosci. 2021 Dec 02;14:759404
pubmed: 34924953
Brain Res Dev Brain Res. 1993 Jan 15;71(1):93-100
pubmed: 8432004
Prog Neurobiol. 2011 Jul;94(2):91-101
pubmed: 21527310
J Exp Zool. 1948 Apr;107(3):315-95
pubmed: 18915618
Acta Neuropathol. 2020 Nov;140(5):695-713
pubmed: 32803350
Development. 2013 Aug;140(15):3069-77
pubmed: 23861056
Am J Physiol Cell Physiol. 2001 Mar;280(3):C556-64
pubmed: 11171575
Mol Biol Cell. 2016 Sep 21;:
pubmed: 27654945
Biophys J. 2001 Jan;80(1):149-54
pubmed: 11159390
Biophys J. 2022 Feb 1;121(3):374-382
pubmed: 34979131
Front Mol Biosci. 2020 Aug 07;7:195
pubmed: 32850976
Nano Lett. 2020 May 13;20(5):3633-3641
pubmed: 32208704
Biophys J. 2015 Mar 10;108(5):1027-37
pubmed: 25762315
Bio Protoc. 2018 Jan 5;8(1):
pubmed: 29552591
Nat Cell Biol. 2014 Mar;16(3):224-33
pubmed: 24561618
Mol Cell Neurosci. 2009 Feb;40(2):128-42
pubmed: 19022387
Curr Biol. 2016 Feb 22;26(4):R153-4
pubmed: 26906482
Neuron. 2019 Apr 3;102(1):184-201.e8
pubmed: 30772082
Exp Cell Res. 2015 May 15;334(1):35-44
pubmed: 25612908
Curr Biol. 2004 Jul 13;14(13):R525-37
pubmed: 15242636
Cell Rep. 2013 Dec 26;5(6):1564-75
pubmed: 24332852
Methods. 2017 Feb 15;115:55-64
pubmed: 27890650
Nano Lett. 2019 Apr 10;19(4):2598-2602
pubmed: 30835477
J Cell Biol. 2006 May 8;173(3):373-81
pubmed: 16682527
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Biophys J. 2018 Nov 20;115(10):2026-2033
pubmed: 30473016
Soft Matter. 2020 Apr 1;16(13):3195-3202
pubmed: 32096811
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15815-20
pubmed: 16236721
Neuron. 2016 Oct 19;92(2):449-460
pubmed: 27764672
ACS Nano. 2015;9(4):3664-76
pubmed: 25801533
Neuron. 2012 Nov 21;76(4):750-61
pubmed: 23177960
Cell. 2019 Sep 19;179(1):147-164.e20
pubmed: 31539493