The human placenta shapes the phenotype of decidual macrophages.

Pregnancy Female Humans Pregnancy Trimester, First / physiology Decidua / metabolism Trophoblasts / metabolism Phenotype Macrophages / metabolism
CP: Immunology antigen-presenting cell decidua basalis decidua parietalis extravillous trophoblast human placentation immune cell distribution macrophage pregnancy

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
31 01 2023
Historique:
received: 01 04 2022
revised: 07 09 2022
accepted: 22 12 2022
pubmed: 15 1 2023
medline: 7 2 2023
entrez: 14 1 2023
Statut: ppublish

Résumé

During human pregnancy, placenta-derived extravillous trophoblasts (EVTs) invade the decidua and communicate with maternal immune cells. The decidua distinguishes into basalis (decB) and parietalis (decP). The latter remains unaffected by EVT invasion. By defining a specific gating strategy, we report the accumulation of macrophages in decB. We describe a decidua basalis-associated macrophage (decBAM) population with a differential transcriptome and secretome compared with decidua parietalis-associated macrophages (decPAMs). decBAMs are CD11c

Identifiants

DOI: 10.1016/j.celrep.2022.111977 PMID: 36640334
pubmed: 36640334
pii: S2211-1247(22)01881-2
doi: 10.1016/j.celrep.2022.111977
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

111977

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Sigrid Vondra (S)

Department of Obstetrics and Gynecology, Reproductive Biology Unit, Maternal-fetal Immunology Group, Medical University of Vienna, Vienna, Austria.

Anna-Lena Höbler (AL)

Department of Obstetrics and Gynecology, Reproductive Biology Unit, Maternal-fetal Immunology Group, Medical University of Vienna, Vienna, Austria.

Andreas Ian Lackner (AI)

Department of Obstetrics and Gynecology, Reproductive Biology Unit, Maternal-fetal Immunology Group, Medical University of Vienna, Vienna, Austria.

Johanna Raffetseder (J)

Division of Inflammation and Infection (II), Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden.

Zala Nikita Mihalic (ZN)

Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, Austria.

Andrea Vogel (A)

Institute for Vascular Biology, Center for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.

Leila Saleh (L)

Department of Obstetrics and Gynecology, Reproductive Biology Unit, Placental Development Group, Medical University of Vienna, Vienna, Austria.

Victoria Kunihs (V)

Department of Obstetrics and Gynecology, Reproductive Biology Unit, Placental Development Group, Medical University of Vienna, Vienna, Austria.

Peter Haslinger (P)

Department of Obstetrics and Gynecology, Reproductive Biology Unit, Maternal-fetal Immunology Group, Medical University of Vienna, Vienna, Austria.

Markus Wahrmann (M)

Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.

Heinrich Husslein (H)

Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.

Raimund Oberle (R)

Center for Pathobiochemistry and Genetics, Institute of Medical Chemistry, Medical University of Vienna, Vienna, Austria.

Julia Kargl (J)

Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, Austria.

Sandra Haider (S)

Institute for Vascular Biology, Center for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria.

Paulina Latos (P)

Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria.

Gernot Schabbauer (G)

Institute for Vascular Biology, Center for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.

Martin Knöfler (M)

Institute for Vascular Biology, Center for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria.

Jan Ernerudh (J)

Department of Clinical Immunology and Transfusion Medicine, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Jürgen Pollheimer (J)

Department of Obstetrics and Gynecology, Reproductive Biology Unit, Maternal-fetal Immunology Group, Medical University of Vienna, Vienna, Austria. Electronic address: juergen.pollheimer@muv.ac.at.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › The human placenta shapes the phenotype of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The human placenta shapes the phenotype of...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Trimestres de grossesse › Premier trimestre de grossesse › The human placenta shapes the phenotype of...
questionsmedicales.fr › Structures de l'embryon › Placenta › Caduques › The human placenta shapes the phenotype of...
questionsmedicales.fr › Structures de l'embryon › Placenta › Trophoblastes › The human placenta shapes the phenotype of...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › The human placenta shapes the phenotype of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › The human placenta shapes the phenotype of...