Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity.

Humans HIV Infections / metabolism CD4-Positive T-Lymphocytes HIV-1 env Gene Products, Human Immunodeficiency Virus / metabolism HIV Seropositivity HIV Antibodies / metabolism Epitopes / metabolism Antibody-Dependent Cell Cytotoxicity
BST-2 CD4 CP: Immunology HIV envelope accessory proteins antibody-dependent cellular cytotoxicity bNAbs nnAbs open conformation, closed conformation

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
31 01 2023
Historique:
received: 30 06 2022
revised: 25 10 2022
accepted: 22 12 2022
pubmed: 15 1 2023
medline: 7 2 2023
entrez: 14 1 2023
Statut: ppublish

Résumé

HIV-1 envelope (Env) conformation determines the susceptibility of infected CD4

Identifiants

DOI: 10.1016/j.celrep.2022.111983 PMID: 36640355 PMC: PMC9941794
pubmed: 36640355
pii: S2211-1247(22)01887-3
doi: 10.1016/j.celrep.2022.111983
pmc: PMC9941794
mid: NIHMS1870528
pii:
doi:

Substances chimiques

env Gene Products, Human Immunodeficiency Virus 0
HIV Antibodies 0
Epitopes 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

111983

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI148379
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI150471
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129769
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI164570
Pays : United States
Organisme : NIGMS NIH HHS
ID : P01 GM056550
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI162646
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI164562
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI150322
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI150590
Pays : United States

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Annemarie Laumaea (A)

Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada. Electronic address: annemarie.laumaea@umontreal.ca.

Lorie Marchitto (L)

Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.

Shilei Ding (S)

Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.

Guillaume Beaudoin-Bussières (G)

Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.

Jérémie Prévost (J)

Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.

Romain Gasser (R)

Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.

Debashree Chatterjee (D)

Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.

Gabrielle Gendron-Lepage (G)

Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.

Halima Medjahed (H)

Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.

Hung-Ching Chen (HC)

Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104-6323, USA.

Amos B Smith (AB)

Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104-6323, USA.

Haitao Ding (H)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

John C Kappes (JC)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, AL 35233, USA.

Beatrice H Hahn (BH)

Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6076, USA.

Frank Kirchhoff (F)

Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.

Jonathan Richard (J)

Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.

Ralf Duerr (R)

Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA.

Andrés Finzi (A)

Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada. Electronic address: andres.finzi@umontreal.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Small CD4 mimetics sensitize HIV-1-infected...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Small CD4 mimetics sensitize HIV-1-infected...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Small CD4 mimetics sensitize HIV-1-infected...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Small CD4 mimetics sensitize HIV-1-infected...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Produits du gène env › Produits du gène env du virus de l'immunodéficience humaine › Small CD4 mimetics sensitize HIV-1-infected...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Séropositivité VIH › Small CD4 mimetics sensitize HIV-1-infected...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Anticorps antideltarétrovirus › Anticorps anti-VIH › Small CD4 mimetics sensitize HIV-1-infected...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Small CD4 mimetics sensitize HIV-1-infected...
questionsmedicales.fr › Phénomènes du système immunitaire › Cytotoxicité immunologique › Cytotoxicité à médiation cellulaire dépendante des anticorps › Small CD4 mimetics sensitize HIV-1-infected...