Short-term air pollution and temperature exposure and changes in the extracellular microRNA profile of Normative Aging Study (NAS) participants.

Humans Aging Air Pollutants / adverse effects Air Pollution / adverse effects Environmental Exposure / adverse effects MicroRNAs / analysis Nitrogen Dioxide / adverse effects Ozone / adverse effects Particulate Matter / adverse effects Temperature
Air pollution Ambient temperature Nitrogen dioxide Ozone Particulate matter microRNA

Journal

Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270

Informations de publication

Date de publication:
01 2023
Historique:
received: 16 10 2022
revised: 02 01 2023
accepted: 04 01 2023
pmc-release: 10 01 2024
pubmed: 15 1 2023
medline: 24 1 2023
entrez: 14 1 2023
Statut: ppublish

Résumé

While the health effects of air pollution and temperature are widely studied, the molecular effects are poorly understood. Extracellular microRNAs (ex-miRNAs) have the potential to serve as diagnostic or prognostic biomarkers and/or to act as intercellular signaling molecules that mediate the effects of environmental exposures on health outcomes. We examined the relationship between short-term exposure to air pollution and ambient temperature and the ex-miRNA profiles of participants in the Normative Aging Study (NAS) from 1999 to 2015. Our exposures were defined as same-day, two-day, three-day, one-week, two-week, and three-week moving averages of PM We found that all the examined exposures were associated with changes in ex-miRNA profiles in our study, particularly PM Air pollution and temperature exposures were significantly associated with alterations in the ex-miRNA profiles of NAS subjects with possible biological consequences.

Sections du résumé

BACKGROUND
While the health effects of air pollution and temperature are widely studied, the molecular effects are poorly understood. Extracellular microRNAs (ex-miRNAs) have the potential to serve as diagnostic or prognostic biomarkers and/or to act as intercellular signaling molecules that mediate the effects of environmental exposures on health outcomes.
METHODS
We examined the relationship between short-term exposure to air pollution and ambient temperature and the ex-miRNA profiles of participants in the Normative Aging Study (NAS) from 1999 to 2015. Our exposures were defined as same-day, two-day, three-day, one-week, two-week, and three-week moving averages of PM
RESULTS
We found that all the examined exposures were associated with changes in ex-miRNA profiles in our study, particularly PM
CONCLUSIONS
Air pollution and temperature exposures were significantly associated with alterations in the ex-miRNA profiles of NAS subjects with possible biological consequences.

Identifiants

DOI: 10.1016/j.envint.2023.107735 PMID: 36640488 PMC: PMC10159015
pubmed: 36640488
pii: S0160-4120(23)00008-9
doi: 10.1016/j.envint.2023.107735
pmc: PMC10159015
mid: NIHMS1889903
pii:
doi:

Substances chimiques

Air Pollutants 0
MicroRNAs 0
nas 64706-31-6
Nitrogen Dioxide S7G510RUBH
Ozone 66H7ZZK23N
Particulate Matter 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

107735

Subventions

Organisme : Intramural NIH HHS
ID : Z99 ES999999
Pays : United States

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: [Dr. Feiby L. Nassan is a current employee and a shareholder of Biogen, Cambridge, MA. The original work on this study at Harvard T. H. Chan School of Public Health (HSPH), however, pre-dated the current employment. This manuscript does not mention any Biogen products or any of the disease states that Biogen is actively doing research in (to the coauthor’s knowledge). Dr. Joel D. Schwartz has appeared as an expert witness on behalf of the US Department of Justice in cases involving violations of the Clean Air Act.].

Références

Environ Res. 2018 Nov;167:640-649
pubmed: 30216846
Environ Health Perspect. 2015 May;123(5):381-9
pubmed: 25625876
Circ Res. 2011 Jan 21;108(2):219-34
pubmed: 21252150
Am J Respir Crit Care Med. 2022 May 1;205(9):1075-1083
pubmed: 35073244
Part Fibre Toxicol. 2017 Aug 24;14(1):32
pubmed: 28899404
Environ Sci Technol. 2020 Sep 15;54(18):11037-11047
pubmed: 32808786
Curr Opin Cell Biol. 2009 Jun;21(3):452-60
pubmed: 19450959
Pharmacol Res. 2021 Jul;169:105635
pubmed: 33930530
Environ Int. 2019 Sep;130:104909
pubmed: 31272018
Environ Sci Technol. 2020 Feb 4;54(3):1372-1384
pubmed: 31851499
Occup Environ Med. 2015 Sep;72(9):656-63
pubmed: 26163546
Cells. 2021 Jan 18;10(1):
pubmed: 33477668
J Immunol Res. 2018 Feb 8;2018:3696914
pubmed: 29577047
Nucleic Acids Res. 2015 Jul 1;43(W1):W460-6
pubmed: 25977294
Cell Metab. 2019 Oct 1;30(4):656-673
pubmed: 31447320
Environ Int. 2018 Apr;113:26-34
pubmed: 29421404
Adv Drug Deliv Rev. 2020;159:198-213
pubmed: 31987838
Environ Int. 2022 Nov;169:107502
pubmed: 36095930
Gerontologist. 1966 Dec;6(4):179-84
pubmed: 5342911
Curr Environ Health Rep. 2022 Sep;9(3):465-476
pubmed: 35449498
Epidemiology. 2015 May;26(3):310-20
pubmed: 25710246
Environ Int. 2021 Nov;156:106715
pubmed: 34218186
Circulation. 2021 Apr 20;143(16):1584-1596
pubmed: 33611922
Genome Biol. 2014;15(12):550
pubmed: 25516281
Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):486-498
pubmed: 27890702
J Toxicol Environ Health A. 2020 May 2;83(9):351-362
pubmed: 32414303
Am J Respir Crit Care Med. 2023 Jan 1;207(1):50-59
pubmed: 35943330
J Appl Toxicol. 2015 Jan;35(1):59-67
pubmed: 24515752
JCI Insight. 2018 Mar 22;3(6):
pubmed: 29563341
Cell. 2019 Apr 4;177(2):446-462.e16
pubmed: 30951671
N Engl J Med. 1993 Dec 9;329(24):1753-9
pubmed: 8179653
Bioinformatics. 2014 Feb 15;30(4):523-30
pubmed: 24336805
Proc Am Thorac Soc. 2005;2(1):61-7
pubmed: 16113470
Lancet Planet Health. 2020 Dec;4(12):e557-e565
pubmed: 33091388
N Engl J Med. 2017 Jun 29;376(26):2513-2522
pubmed: 28657878
Environ Res. 2014 Jul;132:168-75
pubmed: 24792413
Nature. 2016 Jan 21;529(7586):326-35
pubmed: 26791723
Occup Environ Med. 2013 Jun;70(6):426-31
pubmed: 23322918
Physiol Rev. 2010 Jan;90(1):207-58
pubmed: 20086077
Sci Total Environ. 2022 Oct 15;843:156855
pubmed: 35750164
Sci Rep. 2018 Jul 27;8(1):11355
pubmed: 30054496
J Extracell Vesicles. 2022 May;11(5):e12222
pubmed: 35536587
Environ Int. 2019 Jul;128:193-200
pubmed: 31059914
Cell. 2008 Jan 11;132(1):9-14
pubmed: 18191211
Toxicol Lett. 2016 Sep 30;259:143-150
pubmed: 27506416
Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8
pubmed: 18663219
J Neurosci Res. 2020 May;98(5):796-814
pubmed: 31705587
Part Fibre Toxicol. 2016 Mar 08;13:13
pubmed: 26956024
Cytokine Growth Factor Rev. 2020 Feb;51:12-18
pubmed: 31901309
Glob Epidemiol. 2022 Dec;4:
pubmed: 36644436
Environ Res. 2018 Feb;161:168-180
pubmed: 29149680
Cardiovasc Diabetol. 2019 Nov 13;18(1):151
pubmed: 31722714

Auteurs

Mahdieh Danesh Yazdi (M)

Program in Public Health, Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA; Department of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, USA. Electronic address: mahdieh.daneshyazdi@stonybrookmedicine.edu.

Feiby L Nassan (FL)

Department of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, USA; Biogen Inc, Cambridge, MA, USA.

Anna Kosheleva (A)

Department of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, USA.

Cuicui Wang (C)

Department of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, USA.

Zongli Xu (Z)

Laboratory of Molecular Carcinogenesis and Biostatistics Branch, National Institute of Environmental Health Sciences, Durham, NC, USA.

Qian Di (Q)

Vanke School of Public Health, Tsinghua University, Beijing, China.

Weeberb J Requia (WJ)

School of Public Policy and Government, Fundação Getúlio Vargas, Brasília, Distrito Federal, Brazil.

Nicole T Comfort (NT)

Department of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY, USA.

Haotian Wu (H)

Department of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY, USA.

Louise C Laurent (LC)

Department of Obstetrics, Gynecology, & Reproductive Sciences, University of California San Diego, La Jolla, CA, USA.

Peter DeHoff (P)

Department of Obstetrics, Gynecology, & Reproductive Sciences, University of California San Diego, La Jolla, CA, USA.

Pantel Vokonas (P)

Department of Veterans Affairs, Boston, MA, USA; Department of Medicine, Boston University Chobanian and Avidisian School of Medicine, Boston, MA, USA.

Andrea A Baccarelli (AA)

Department of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY, USA.

Joel D Schwartz (JD)

Department of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Short-term air pollution and temperature...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Short-term air pollution and temperature...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Polluants atmosphériques › Short-term air pollution and temperature...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Pollution de l'air › Short-term air pollution and temperature...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Short-term air pollution and temperature...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Short-term air pollution and temperature...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Dioxyde d'azote › Short-term air pollution and temperature...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › Ozone › Short-term air pollution and temperature...
questionsmedicales.fr › Mélanges complexes › Matière particulaire › Short-term air pollution and temperature...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Température › Short-term air pollution and temperature...