Animal toxins: As an alternative therapeutic target following ischemic stroke condition.
ASICs Channel
Animal toxin
Ischemic stroke
Neuroprotection
Organelles
VDCCs Channel
Journal
Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521
Informations de publication
Date de publication:
15 Mar 2023
15 Mar 2023
Historique:
received:
15
07
2022
revised:
29
11
2022
accepted:
31
12
2022
pubmed:
15
1
2023
medline:
25
2
2023
entrez:
14
1
2023
Statut:
ppublish
Résumé
Globally, Ischemic stroke (IS) has become the second leading cause of mortality and chronic disability. The process of IS has triggered by the blockages of blood vessels to form clots in the brain which initiates multiple interactions with the key signaling pathways, counting excitotoxicity, acidosis, ionic imbalance, inflammation, oxidative stress, and neuronal dysfunction of cells, and ultimately cells going under apoptosis. Currently, FDA has approved only tissue plasminogen activator therapy, which is effective against IS with few limitations. However, the mechanism of excitotoxicity and acidosis has spurred the investigation of a potential candidate for IS therapy. Acid-sensing ion channels (ASICs) and Voltage-gated Ca
Identifiants
pubmed: 36640901
pii: S0024-3205(22)01065-7
doi: 10.1016/j.lfs.2022.121365
pii:
doi:
Substances chimiques
Tissue Plasminogen Activator
EC 3.4.21.68
Acid Sensing Ion Channels
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
121365Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no conflict of interest.