A numerical model for fibril remodeling in articular cartilage.
Articular cartilage
Collagen fibril
Finite element model
Porcine knee cartilage
Split-lines
Journal
The Knee
ISSN: 1873-5800
Titre abrégé: Knee
Pays: Netherlands
ID NLM: 9430798
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
12
07
2022
revised:
05
11
2022
accepted:
14
12
2022
medline:
25
4
2023
pubmed:
16
1
2023
entrez:
15
1
2023
Statut:
ppublish
Résumé
Collagen fibrils of articular cartilage have a distinct organization in mature human knee joints. It seems that a mechanobiological process drives the remodeling of newborn collagen fibrils with maturation. Therefore, the goal of the present study was to develop a collagen fibril remodeling algorithm that describes the unique collagen fibril organization in a 3D knee model. A fibril-reinforced, biphasic cartilage model was used with a cuboid and a 3D human knee joint geometries. An isotropic collagen fibril distribution was assigned to the cartilage at the start of the analysis. Each fibril was rotated towards the direction that resulted in a maximum stretch at each time increment of the loading cycle. The resulting pattern for the collagen fibrils was compared with split line patterns of porcine knee joint cartilage and also data published in the literature. Fibrils on the articular surface had a radial pattern towards the geometrical centroid of the tibial and femoral cartilage. In the tibiofemoral contact regions of superficial zone, fibrils were oriented circumferentially and randomly. In the porcine samples, the split-line patterns were similar to those obtained theoretically. Depth-wise organization of fibril network was characterized by fibrils perpendicular to the subchondral bone in the deeper layers, and fibrils parallel to the surface of cartilage in the superficial zone. The maximum stretch criterion, coupled with a biphasic constitutive model, successfully predicted the collagen fibril organization observed in the articular cartilage throughout the depth and on the articular surface.
Sections du résumé
BACKGROUND
BACKGROUND
Collagen fibrils of articular cartilage have a distinct organization in mature human knee joints. It seems that a mechanobiological process drives the remodeling of newborn collagen fibrils with maturation. Therefore, the goal of the present study was to develop a collagen fibril remodeling algorithm that describes the unique collagen fibril organization in a 3D knee model.
METHOD
METHODS
A fibril-reinforced, biphasic cartilage model was used with a cuboid and a 3D human knee joint geometries. An isotropic collagen fibril distribution was assigned to the cartilage at the start of the analysis. Each fibril was rotated towards the direction that resulted in a maximum stretch at each time increment of the loading cycle.
RESULTS
RESULTS
The resulting pattern for the collagen fibrils was compared with split line patterns of porcine knee joint cartilage and also data published in the literature. Fibrils on the articular surface had a radial pattern towards the geometrical centroid of the tibial and femoral cartilage. In the tibiofemoral contact regions of superficial zone, fibrils were oriented circumferentially and randomly. In the porcine samples, the split-line patterns were similar to those obtained theoretically. Depth-wise organization of fibril network was characterized by fibrils perpendicular to the subchondral bone in the deeper layers, and fibrils parallel to the surface of cartilage in the superficial zone.
CONCLUSIONS
CONCLUSIONS
The maximum stretch criterion, coupled with a biphasic constitutive model, successfully predicted the collagen fibril organization observed in the articular cartilage throughout the depth and on the articular surface.
Identifiants
pubmed: 36642036
pii: S0968-0160(22)00220-4
doi: 10.1016/j.knee.2022.12.009
pii:
doi:
Substances chimiques
Collagen
9007-34-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
83-96Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.