Kupffer Cells Contested as Early Drivers in the Pathogenesis of Primary Sclerosing Cholangitis.

Mice Animals Cholangitis, Sclerosing / pathology Kupffer Cells / pathology Liver / pathology Cholestasis / pathology

Journal

The American journal of pathology
ISSN: 1525-2191
Titre abrégé: Am J Pathol
Pays: United States
ID NLM: 0370502

Informations de publication

Date de publication:
04 2023
Historique:
received: 14 10 2022
revised: 19 12 2022
accepted: 20 12 2022
medline: 4 4 2023
pubmed: 16 1 2023
entrez: 15 1 2023
Statut: ppublish

Résumé

Primary sclerosing cholangitis (PSC) is an idiopathic chronic immune-mediated cholestatic liver disease characterized by fibro-inflammatory bile duct strictures, progressive hepatobiliary fibrosis, and gut-liver axis disruption. The pathophysiology of PSC remains insufficiently characterized, which hampers the development of effective therapies. Hepatic macrophages (MFs) such as Kupffer cells (KCs) are implicated in PSC pathogenesis, but their exact role is unclear. Using the latest markers to discriminate resident KCs (ResKCs) from their monocyte-derived counterparts (MoKCs), and two models of intrahepatic and extrahepatic cholestasis, respectively, this study showed that CLEC4F

Identifiants

DOI: 10.1016/j.ajpath.2022.12.008 PMID: 36642171
pubmed: 36642171
pii: S0002-9440(23)00002-0
doi: 10.1016/j.ajpath.2022.12.008
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

366-379

Informations de copyright

Copyright © 2023 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Auteurs

Kevin De Muynck (K)

Gut-Liver Immunopharmacology Unit, Department of Basic and Applied Medical Sciences, Liver Research Center Ghent, Ghent University, Ghent, Belgium; Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Liver Research Center Ghent, Ghent University, Ghent, Belgium.

Bart Vanderborght (B)

Gut-Liver Immunopharmacology Unit, Department of Basic and Applied Medical Sciences, Liver Research Center Ghent, Ghent University, Ghent, Belgium; Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Liver Research Center Ghent, Ghent University, Ghent, Belgium.

Federico F De Ponti (FF)

Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium; Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, Vlaams Instituut voor Biotechnologie-UGent Center for Inflammation Research, Ghent, Belgium.

Eva Gijbels (E)

Gut-Liver Immunopharmacology Unit, Department of Basic and Applied Medical Sciences, Liver Research Center Ghent, Ghent University, Ghent, Belgium; Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium.

Sophie Van Welden (S)

Inflammatory Bowel Disease Research Unit, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Intestinal Barrier Signaling in Disease and Therapy, Vlaams Instituut voor Biotechnologie-UGent Center for Inflammation Research, Ghent, Belgium.

Martin Guilliams (M)

Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium; Laboratory of Myeloid Cell Biology in Tissue Homeostasis and Regeneration, Vlaams Instituut voor Biotechnologie-UGent Center for Inflammation Research, Ghent, Belgium.

Charlotte L Scott (CL)

Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium; Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, Vlaams Instituut voor Biotechnologie-UGent Center for Inflammation Research, Ghent, Belgium.

Alain Beschin (A)

Cellular & Molecular Immunology Research Group, Vrije Universiteit Brussel, Brussels, Belgium; Myeloid Cell Immunology Lab, Vlaams Instituut voor Biotechnologie-Vrije Universiteit Brussel, Brussels, Belgium.

Mathieu Vinken (M)

Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium.

Sander Lefere (S)

Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Liver Research Center Ghent, Ghent University, Ghent, Belgium.

Anja Geerts (A)

Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Liver Research Center Ghent, Ghent University, Ghent, Belgium; Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium.

Xavier Verhelst (X)

Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Liver Research Center Ghent, Ghent University, Ghent, Belgium; Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium.

Hans Van Vlierberghe (H)

Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Liver Research Center Ghent, Ghent University, Ghent, Belgium; Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium.

Lindsey Devisscher (L)

Gut-Liver Immunopharmacology Unit, Department of Basic and Applied Medical Sciences, Liver Research Center Ghent, Ghent University, Ghent, Belgium. Electronic address: lindsey.devisscher@ugent.be.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Kupffer Cells Contested as Early Drivers in...
questionsmedicales.fr › Eucaryotes › Animaux › Kupffer Cells Contested as Early Drivers in...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladie des voies biliaires › Maladies des canaux biliaires › Angiocholite › Angiocholite sclérosante › Kupffer Cells Contested as Early Drivers in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Cellules de Küpffer › Kupffer Cells Contested as Early Drivers in...
questionsmedicales.fr › Système digestif › Foie › Kupffer Cells Contested as Early Drivers in...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladie des voies biliaires › Maladies des canaux biliaires › Cholestase › Kupffer Cells Contested as Early Drivers in...