Spike-specific T cells are enriched in breastmilk following SARS-CoV-2 mRNA vaccination.

Infant Female Humans Milk, Human SARS-CoV-2 T-Lymphocytes Lactation COVID-19 Vaccination RNA, Messenger Antibodies, Viral

Journal

Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742

Informations de publication

Date de publication:
02 2023
Historique:
received: 07 11 2022
revised: 20 12 2022
accepted: 07 01 2023
pubmed: 16 1 2023
medline: 15 3 2023
entrez: 15 1 2023
Statut: ppublish

Résumé

Human breastmilk is rich in T cells; however, their specificity and function are largely unknown. We compared the phenotype, diversity, and antigen specificity of T cells in breastmilk and peripheral blood of lactating individuals who received SARS-CoV-2 messenger RNA (mRNA) vaccination. Relative to blood, breastmilk contained higher frequencies of T effector and central memory populations that expressed mucosal-homing markers. T cell receptor sequence overlap was limited between blood and breastmilk. Overabundant breastmilk clones were observed in all individuals, were diverse, and contained complementarity-determining regions in three sequences with known epitope specificity, including to SARS-CoV-2 spike. SARS-CoV-2 spike-specific T cell receptors were more frequent in breastmilk compared to blood and expanded in breastmilk following a 3

Identifiants

DOI: 10.1016/j.mucimm.2023.01.003 PMID: 36642379 PMC: PMC9836998
pubmed: 36642379
pii: S1933-0219(23)00003-X
doi: 10.1016/j.mucimm.2023.01.003
pmc: PMC9836998
pii:
doi:

Substances chimiques

RNA, Messenger 0
Antibodies, Viral 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

39-49

Subventions

Organisme : NIAID NIH HHS
ID : T32 AI007509
Pays : United States
Organisme : NIAID NIH HHS
ID : K08 AI148588
Pays : United States
Organisme : NIAID NIH HHS
ID : K08 AI135072
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI148373
Pays : United States
Organisme : NIAID NIH HHS
ID : K23 AI153390
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI163999
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA080416
Pays : United States

Commentaires et corrections

Type : UpdateOf

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

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Auteurs

Blair Armistead (B)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.

Yonghou Jiang (Y)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.

Marc Carlson (M)

Research Scientific Computing, Enterprise Analytics, Seattle Children's Research Institute, Seattle, Washington, USA.

Emily S Ford (ES)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; Department of Medicine, University of Washington, Seattle, Washington, USA.

Saumya Jani (S)

Department of Medicine, University of Washington, Seattle, Washington, USA; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, Washington, USA.

John Houck (J)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.

Xia Wu (X)

Department of Medicine, University of Washington, Seattle, Washington, USA.

Lichen Jing (L)

Department of Medicine, University of Washington, Seattle, Washington, USA.

Tiffany Pecor (T)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.

Alisa Kachikis (A)

Department of Obstetrics & Gynecology, University of Washington, Seattle, Washington, USA.

Winnie Yeung (W)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.

Tina Nguyen (T)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.

Rene Coig (R)

Department of Laboratory Medicine & Pathology, University of Washington, Seattle, Washington, USA.

Nana Minkah (N)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA; Department of Pediatrics, University of Washington, Seattle, Washington, USA.

Sasha E Larsen (SE)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.

Rhea N Coler (RN)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA; Department of Pediatrics, University of Washington, Seattle, Washington, USA; Department of Global Health, University of Washington, Seattle, Washington, USA.

David M Koelle (DM)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; Department of Medicine, University of Washington, Seattle, Washington, USA; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, Washington, USA; Department of Global Health, University of Washington, Seattle, Washington, USA; Benaroya Research Institute, Seattle, Washington, USA.

Whitney E Harrington (WE)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA; Department of Pediatrics, University of Washington, Seattle, Washington, USA; Department of Global Health, University of Washington, Seattle, Washington, USA. Electronic address: whitney.harrington@seattlechildrens.org.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Spike-specific T cells are enriched in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Spike-specific T cells are enriched in...
questionsmedicales.fr › Aliments et boissons › Aliments › Produits laitiers › Lait › Lait humain › Spike-specific T cells are enriched in...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Spike-specific T cells are enriched in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Spike-specific T cells are enriched in...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Période du postpartum › Lactation › Spike-specific T cells are enriched in...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Spike-specific T cells are enriched in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Prévention primaire › Immunisation › Vaccination › Spike-specific T cells are enriched in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Spike-specific T cells are enriched in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Spike-specific T cells are enriched in...