The Impact of the Cellular Environment and Aging on Modeling Alzheimer's Disease in 3D Cell Culture Models.
Alzheimer
hydrogel
neurodegeneration
nonclassical crystallization
synthetic extracellular matrix
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
revised:
29
11
2022
received:
01
09
2022
pubmed:
17
1
2023
medline:
21
3
2023
entrez:
16
1
2023
Statut:
ppublish
Résumé
Creating a cellular model of Alzheimer's disease (AD) that accurately recapitulates disease pathology has been a longstanding challenge. Recent studies showed that human AD neural cells, integrated into three-dimensional (3D) hydrogel matrix, display key features of AD neuropathology. Like in the human brain, the extracellular matrix (ECM) plays a critical role in determining the rate of neuropathogenesis in hydrogel-based 3D cellular models. Aging, the greatest risk factor for AD, significantly alters brain ECM properties. Therefore, it is important to understand how age-associated changes in ECM affect accumulation of pathogenic molecules, neuroinflammation, and neurodegeneration in AD patients and in vitro models. In this review, mechanistic hypotheses is presented to address the impact of the ECM properties and their changes with aging on AD and AD-related dementias. Altered ECM characteristics in aged brains, including matrix stiffness, pore size, and composition, will contribute to disease pathogenesis by modulating the accumulation, propagation, and spreading of pathogenic molecules of AD. Emerging hydrogel-based disease models with differing ECM properties provide an exciting opportunity to study the impact of brain ECM aging on AD pathogenesis, providing novel mechanistic insights. Understanding the role of ECM aging in AD pathogenesis should also improve modeling AD in 3D hydrogel systems.
Identifiants
pubmed: 36642841
doi: 10.1002/advs.202205037
pmc: PMC10015857
doi:
Substances chimiques
Hydrogels
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2205037Subventions
Organisme : NIA NIH HHS
ID : R01 AG061891
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057635
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062547
Pays : United States
Informations de copyright
© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
Références
Am J Pathol. 1988 Dec;133(3):456-63
pubmed: 2974240
J Nucl Med. 2017 Sep;58(9):1471-1476
pubmed: 28302766
J Neurosci Res. 2023 Jan;101(1):3-19
pubmed: 36200530
Tissue Eng Part B Rev. 2010 Aug;16(4):371-83
pubmed: 20121414
J Neurosci Res. 2007 Aug 1;85(10):2138-46
pubmed: 17520747
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):330-5
pubmed: 12506200
Neuron. 2015 Jan 21;85(2):296-302
pubmed: 25611508
Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E476-E485
pubmed: 27930341
Sci Rep. 2018 Jan 8;8(1):62
pubmed: 29311640
Nat Protoc. 2018 Sep;13(9):2062-2085
pubmed: 30202107
J Struct Biol. 2009 Sep;167(3):216-9
pubmed: 19481153
Hum Mol Genet. 2014 Jul 1;23(13):3523-36
pubmed: 24524897
Lab Chip. 2015 Jan 7;15(1):141-50
pubmed: 25317977
J Virol Methods. 2011 May;173(2):266-70
pubmed: 21354210
Biomaterials. 1999 Jan;20(1):45-53
pubmed: 9916770
J Histochem Cytochem. 1992 Jan;40(1):105-13
pubmed: 1370306
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9758-63
pubmed: 23703910
ACS Biomater Sci Eng. 2018 Dec 10;4(12):4278-4288
pubmed: 33304995
Exp Cell Res. 2007 Aug 15;313(14):3066-75
pubmed: 17524393
Nat Methods. 2019 Jan;16(1):75-78
pubmed: 30573846
Brain Pathol. 2008 Apr;18(2):253-66
pubmed: 18363936
Nature. 2020 May;581(7806):71-76
pubmed: 32376954
J R Soc Interface. 2020 Jan;17(162):20190505
pubmed: 31910776
Annu Rev Phys Chem. 2018 Apr 20;69:273-298
pubmed: 29490200
Mol Psychiatry. 2020 Jan;25(1):148-167
pubmed: 31391546
Proc Natl Acad Sci U S A. 1966 Jun;55(6):1467-74
pubmed: 5227666
J Biomed Mater Res A. 2004 Nov 1;71(2):191-200
pubmed: 15376189
Annu Rev Biochem. 2017 Jun 20;86:27-68
pubmed: 28498720
J Mol Biol. 2003 Jan 3;325(1):135-48
pubmed: 12473457
Adv Sci (Weinh). 2019 Aug 12;6(20):1900962
pubmed: 31637161
Biomaterials. 2009 Sep;30(27):4567-72
pubmed: 19500834
J Am Chem Soc. 2005 Oct 5;127(39):13472-3
pubmed: 16190691
Neurochem Res. 2015 Dec;40(12):2583-99
pubmed: 25947369
Neuroimage. 2015 May 1;111:59-64
pubmed: 25698157
Neuron. 2018 Jun 27;98(6):1141-1154.e7
pubmed: 29861287
Acta Neuropathol Commun. 2016 Nov 4;4(1):117
pubmed: 27809932
Science. 1997 May 30;276(5317):1425-8
pubmed: 9162012
Cytotechnology. 2015 Oct;67(5):873-83
pubmed: 24744128
Am J Pathol. 1998 Sep;153(3):725-33
pubmed: 9736023
Stem Cell Res. 2019 Oct;40:101541
pubmed: 31522011
Biomaterials. 2011 Nov;32(31):7897-904
pubmed: 21784515
EMBO Mol Med. 2016 Jun 01;8(6):595-608
pubmed: 27025652
Nat Methods. 2016 Apr 28;13(5):405-14
pubmed: 27123816
Mol Neurodegener. 2015 Nov 02;10:58
pubmed: 26526066
Proteomics. 2010 May;10(9):1886-90
pubmed: 20162561
PLoS One. 2012;7(2):e31302
pubmed: 22312444
JAMA Neurol. 2019 Jan 1;76(1):101-108
pubmed: 30193298
Exp Cell Res. 1992 Sep;202(1):1-8
pubmed: 1511725
Nat Protoc. 2015 Jul;10(7):985-1006
pubmed: 26068894
Mol Cell Proteomics. 2009 Jul;8(7):1648-57
pubmed: 19351662
Brain. 2017 Dec 1;140(12):3286-3300
pubmed: 29053874
Langmuir. 2009 Jan 6;25(1):36-9
pubmed: 19049394
Mol Neurobiol. 2018 Apr;55(4):3185-3195
pubmed: 28477140
J Tissue Eng Regen Med. 2009 Dec;3(8):634-46
pubmed: 19813215
Science. 2009 Nov 13;326(5955):1005-7
pubmed: 19779148
Adv Drug Deliv Rev. 2016 Feb 1;97:4-27
pubmed: 26562801
PLoS One. 2020 Jan 13;15(1):e0227641
pubmed: 31929571
Mol Psychiatry. 2018 Dec;23(12):2363-2374
pubmed: 30171212
J Am Chem Soc. 2019 Mar 20;141(11):4490-4504
pubmed: 30753066
Protein Sci. 2000 Oct;9(10):1960-7
pubmed: 11106169
Front Neurosci. 2019 Jul 02;13:698
pubmed: 31312118
Nat Rev Mol Cell Biol. 2014 Dec;15(12):802-12
pubmed: 25355505
ILAR J. 2008;49(3):310-5
pubmed: 18506064
Neuropathol Appl Neurobiol. 2017 Feb;43(2):167-182
pubmed: 26544797
Chembiochem. 2018 Dec 4;19(23):2424-2432
pubmed: 30133080
Biomater Sci. 2019 Aug 1;7(8):3480-3488
pubmed: 31282511
Biotechnol Prog. 2013 Sep-Oct;29(5):1255-64
pubmed: 24474590
Nat Med. 2019 Feb;25(2):270-276
pubmed: 30643288
Sci Transl Med. 2012 Aug 15;4(147):147ra111
pubmed: 22896675
Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):459-65
pubmed: 19896886
Wound Repair Regen. 2000 May-Jun;8(3):226-37
pubmed: 10886813
J Neuropathol Exp Neurol. 2016 Sep;75(9):868-76
pubmed: 27444354
J Mol Biol. 2008 Sep 19;381(5):1332-48
pubmed: 18590743
Nat Med. 2008 Aug;14(8):837-42
pubmed: 18568035
Biotechnol Bioeng. 2000 Aug 20;69(4):359-69
pubmed: 10862674
Brain Res. 1998 Jun 15;796(1-2):171-5
pubmed: 9689467
Proc Natl Acad Sci U S A. 2009 May 12;106(19):7828-33
pubmed: 19416886
Aging Dis. 2018 Oct 1;9(5):880-900
pubmed: 30271665
Curr Opin Biotechnol. 2020 Dec;66:78-87
pubmed: 32711361
Nat Commun. 2015 Jan 22;6:5980
pubmed: 25609143
Nature. 2013 Sep 19;501(7467):373-9
pubmed: 23995685
Brain Res. 1990 Jan 29;508(1):13-9
pubmed: 2140065
Biochim Biophys Acta. 2009 Mar;1794(3):375-97
pubmed: 19071235
Biophys J. 2011 Jan 19;100(2):284-93
pubmed: 21244824
Cell Mol Neurobiol. 2000 Apr;20(2):183-96
pubmed: 10696509
PLoS One. 2016 Sep 29;11(9):e0163072
pubmed: 27684569
Nat Neurosci. 2018 Jul;21(7):941-951
pubmed: 29950669
EMBO Mol Med. 2012 Jul;4(7):660-73
pubmed: 22488900
Trends Cell Biol. 2015 Jun;25(6):364-72
pubmed: 25683921
Amyloid. 1998 Mar;5(1):16-23
pubmed: 9547001
Aging Dis. 2020 Feb 1;11(1):200-211
pubmed: 32010493
Nature. 2019 Sep;573(7772):130-134
pubmed: 31413369
Science. 2019 Feb 22;363(6429):880-884
pubmed: 30679382
Am J Pathol. 1990 Nov;137(5):1253-70
pubmed: 2146882
J Biol Chem. 1993 Nov 15;268(32):24374-84
pubmed: 8226987
Alzheimers Res Ther. 2017 Jun 13;9(1):42
pubmed: 28610595
Stroke. 2013 Jun;44(6 Suppl 1):S93-5
pubmed: 23709744
Neural Regen Res. 2020 Apr;15(4):573-585
pubmed: 31638079
Sci Rep. 2016 Dec 05;6:38187
pubmed: 27917876
Cell. 2005 Feb 25;120(4):545-55
pubmed: 15734686
Nat Commun. 2020 Nov 2;11(1):5540
pubmed: 33139712
Biotechnol Bioeng. 2009 Jul 1;103(4):655-63
pubmed: 19472329
J Neurosci. 2015 Oct 21;35(42):14234-50
pubmed: 26490863
Nat Biotechnol. 2018 Oct;36(9):865-874
pubmed: 30125269
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7
pubmed: 16293696
Brain Res. 1989 Sep 25;498(1):185-9
pubmed: 2790472
Ther Deliv. 2010 Oct;1(4):517-34
pubmed: 22833965
Biophys J. 2017 Nov 21;113(10):2133-2142
pubmed: 28755756
J Neurosci Res. 1984;11(3):241-51
pubmed: 6737517
Methods Mol Biol. 2021;2258:205-219
pubmed: 33340363
Cell. 2006 Aug 25;126(4):677-89
pubmed: 16923388
Science. 2006 Sep 22;313(5794):1781-4
pubmed: 16990547
Cerebrospinal Fluid Res. 2008 May 14;5:10
pubmed: 18479516
Nat Commun. 2014 Mar 06;5:3443
pubmed: 24599114
Cell. 2012 May 25;149(5):1048-59
pubmed: 22632969
Cell Death Discov. 2022 Apr 2;8(1):153
pubmed: 35368019
J Neurosci. 2006 Oct 4;26(40):10129-40
pubmed: 17021169
Adv Sci (Weinh). 2019 Jan 11;6(4):1801716
pubmed: 30828535
Semin Cancer Biol. 2005 Oct;15(5):405-12
pubmed: 16055341
Gerontology. 2020;66(3):266-274
pubmed: 31838471
Nat Med. 2020 Jun;26(6):952-963
pubmed: 32514169
Nat Commun. 2020 Mar 13;11(1):1377
pubmed: 32170138
Neurotox Res. 2018 Oct;34(3):733-748
pubmed: 29626319
Sci Rep. 2018 Feb 5;8(1):2450
pubmed: 29402979
Biomaterials. 2009 Sep;30(26):4377-83
pubmed: 19501396
Stem Cell Rev Rep. 2022 Feb;18(2):718-731
pubmed: 33725267
Adv Sci (Weinh). 2023 Mar;10(8):e2205037
pubmed: 36642841
PLoS One. 2013 Jul 02;8(7):e66101
pubmed: 23843949
Nature. 2018 Apr 4;556(7699):89-94
pubmed: 29620730
Neuroimage Clin. 2015 Dec 19;10:283-90
pubmed: 26900568
Science. 2020 Jul 10;369(6500):
pubmed: 32527923
Acta Neuropathol Commun. 2015 Mar 24;3:14
pubmed: 25853174
Brain Res. 1998 Mar 30;788(1-2):187-90
pubmed: 9555007
Pharmacol Rev. 2012 Jul;64(3):676-705
pubmed: 22722893
J Anat. 2004 Jan;204(1):33-48
pubmed: 14690476
Nat Neurosci. 2016 Dec;19(12):1592-1598
pubmed: 27643431
PLoS One. 2016 Sep 13;11(9):e0161969
pubmed: 27622770
Science. 2013 Oct 18;342(6156):373-7
pubmed: 24136970
J Biol Chem. 1998 Aug 7;273(32):20121-7
pubmed: 9685355
Cell Rep. 2015 May 5;11(5):689-96
pubmed: 25921538
Magn Reson Imaging. 2008 Jun;26(5):694-702
pubmed: 18440744
J Exp Med. 2017 Nov 6;214(11):3151-3169
pubmed: 29061693
Biomaterials. 2015 Feb;42:134-43
pubmed: 25542801
Biochemistry. 2002 Jun 4;41(22):7150-5
pubmed: 12033949
Nat Commun. 2019 Oct 29;10(1):4760
pubmed: 31664019
Biochim Biophys Acta. 2013 Dec;1834(12):2486-93
pubmed: 24016775
J Tissue Eng Regen Med. 2017 Dec;11(12):3494-3507
pubmed: 28032468
Science. 2009 Nov 27;326(5957):1216-9
pubmed: 19965464
Neuroimage. 2021 May 15;232:117889
pubmed: 33617995
Curr Opin Biotechnol. 2013 Oct;24(5):948-53
pubmed: 23611564
Biol Open. 2018 Jul 25;7(7):
pubmed: 30045859
HFSP J. 2007 Jul;1(2):137-46
pubmed: 19404419
Cell. 1993 Jun 18;73(6):1055-8
pubmed: 8513491
Nat Biotechnol. 2017 Jul;35(7):659-666
pubmed: 28562594
Brain Res. 1994 Sep 5;656(1):205-9
pubmed: 7804839
Bioact Mater. 2016 May 12;1(1):39-55
pubmed: 29744394
Prog Neurobiol. 2017 Oct;157:230-246
pubmed: 26837044
ACS Omega. 2020 Aug 06;5(32):20250-20260
pubmed: 32832778
Cells. 2019 Mar 14;8(3):
pubmed: 30875781
Nat Neurosci. 2012 Feb 05;15(3):477-86, S1
pubmed: 22306606
Cancer Cell. 2005 Sep;8(3):241-54
pubmed: 16169468
Nat Med. 1996 Jul;2(7):783-7
pubmed: 8673924
Cell Death Discov. 2022 Jan 10;8(1):1
pubmed: 35013145
Science. 2009 Dec 11;326(5959):1533-7
pubmed: 20007899
J Biomol Screen. 2016 Sep;21(8):804-15
pubmed: 26984927
Fluids Barriers CNS. 2014 May 01;11:10
pubmed: 24817998
Nat Commun. 2021 Sep 1;12(1):5220
pubmed: 34471104
J Biol Chem. 2013 Jan 18;288(3):1856-70
pubmed: 23188818
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13661-5
pubmed: 9391082
Nat Neurosci. 2016 Aug;19(8):1085-92
pubmed: 27322420
J Immunol. 2003 Apr 1;170(7):3850-8
pubmed: 12646653
Neurochem Int. 2004 Sep;45(4):545-52
pubmed: 15186921
Nat Med. 2013 Dec;19(12):1584-96
pubmed: 24309662
Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5567-72
pubmed: 16567637
Brain Res. 2007 Nov 14;1180:121-32
pubmed: 17920047
Tissue Eng Part A. 2014 Aug;20(15-16):2140-50
pubmed: 24813329
Exp Neurol. 1993 Jun;121(2):149-52
pubmed: 8339766
Chem Rev. 2001 Jul;101(7):1869-79
pubmed: 11710233
J Biol Chem. 2012 Jul 13;287(29):24765-73
pubmed: 22547072
Methods Enzymol. 1999;309:256-74
pubmed: 10507029
J Biol Inorg Chem. 2004 Dec;9(8):954-60
pubmed: 15578276
Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10889-94
pubmed: 16832052
Dev Cell. 2018 Jul 2;46(1):85-101.e8
pubmed: 29974866
Nat Chem Biol. 2011 Jul 31;7(9):602-9
pubmed: 21804535
Nat Commun. 2017 Aug 29;8(1):371
pubmed: 28851858
Biochemistry. 2013 Oct 8;52(40):6960-7
pubmed: 24033133
Phys Chem Chem Phys. 2015 Mar 28;17(12):7606-18
pubmed: 25719972
J Cell Biol. 2004 Dec 6;167(5):953-60
pubmed: 15583033
Nat Rev Mol Cell Biol. 2021 Jan;22(1):22-38
pubmed: 33188273
Science. 2015 Jul 31;349(6247):aaa6760
pubmed: 26228157
Sci Rep. 2019 Sep 26;9(1):13939
pubmed: 31558805
Science. 2000 Aug 25;289(5483):1317-21
pubmed: 10958771
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3104-7
pubmed: 10077644
J Neurosci. 2011 Oct 12;31(41):14488-95
pubmed: 21994365
Neuron. 2012 Feb 23;73(4):685-97
pubmed: 22365544
FEBS Lett. 2006 Oct 9;580(23):5525-32
pubmed: 16814780
Chem Sci. 2017 Jun 1;8(6):4352-4362
pubmed: 28979758
J Cell Biochem. 2008 Aug 15;104(6):1964-87
pubmed: 17546585
Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13287-92
pubmed: 9371838
Nat Chem. 2011 Feb;3(2):172-7
pubmed: 21258392
PLoS One. 2014 Jun 27;9(6):e100760
pubmed: 24971751
Sci Transl Med. 2016 Mar 30;8(332):332ra44
pubmed: 27030596