Carcinomatous meningitis from ovarian serous carcinoma: A case report.
headache
leptomeningeal carcinomatosis
meningeal carcinomatosis
ovarian carcinoma
ovarian neoplasm
Journal
Oncology letters
ISSN: 1792-1082
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
30
08
2022
accepted:
30
11
2022
entrez:
16
1
2023
pubmed:
17
1
2023
medline:
17
1
2023
Statut:
epublish
Résumé
Multifocal dissemination of cancer cells from the primary tumor sites to the subarachnoid, pia mater and cerebrospinal fluid (CSF) of the brain and spinal cord causes carcinomatous meningitis (CM). CM is rarely observed in patients with gynecological cancer. The present study described a 59-year-old woman who was diagnosed with CM as a recurrence of stage IIIC ovarian cancer, after presenting with headache and decreased level of consciousness. During adjuvant therapy following surgical debulking, she developed nausea and vomiting. The post-contrast fluid-attenuated inversion-recovery magnetic resonance imaging showed leptomeningeal enhancement on all sulci, particularly around the falx cerebri and cerebellar hemisphere. CM was suspected and CSF cytology revealed adenocarcinoma cells, thus confirming the diagnosis. Overall, although CM is rare, clinicians should be aware of this complication when patients with malignancies experience neurological symptoms, including headache, nausea and vomiting. Knowledge of this clinical entity should assist clinicians in ascertaining accurate diagnoses.
Identifiants
pubmed: 36644158
doi: 10.3892/ol.2022.13652
pii: OL-25-02-13652
pmc: PMC9827457
doi:
Types de publication
Case Reports
Langues
eng
Pagination
66Informations de copyright
Copyright: © Uchikura et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
Références
Surg Neurol Int. 2013 May 02;4(Suppl 4):S265-88
pubmed: 23717798
Med Oncol. 2013 Mar;30(1):429
pubmed: 23292836
Clin Orthop Relat Res. 1995 Mar;(312):4-9
pubmed: 7634616
Oxf Med Case Reports. 2016 Aug 25;2016(8):omw068
pubmed: 27574561
J Neuroradiol. 2006 Dec;33(5):285-91
pubmed: 17213756
J Neurooncol. 2005 Oct;75(1):85-99
pubmed: 16215819
Continuum (Minneap Minn). 2012 Apr;18(2):328-42
pubmed: 22810130
Lancet Neurol. 2006 May;5(5):443-52
pubmed: 16632315
Clin Imaging. 2017 Jan - Feb;41:42-47
pubmed: 27764719
Oncologist. 2008 Sep;13(9):967-77
pubmed: 18776058
Lancet Oncol. 2010 Sep;11(9):871-9
pubmed: 20598636
Ital J Neurol Sci. 1983 Apr;4(1):95-7
pubmed: 6688066
Oncotarget. 2017 Aug 16;8(42):73312-73328
pubmed: 29069871
J Neurol Sci. 2020 Apr 15;411:116706
pubmed: 32007755
J Neurooncol. 2019 Jul;143(3):553-562
pubmed: 31089925
N Engl J Med. 2004 Dec 9;351(24):2519-29
pubmed: 15590954