Biodistribution and pharmacokinetic evaluation of Korean Red Ginseng components using radioisotopes in a rat model.
Autoradiography
Ginsenosides
Korean Red Ginseng
Pharmacokinetics
Radioisotopes
Journal
Journal of ginseng research
ISSN: 1226-8453
Titre abrégé: J Ginseng Res
Pays: Korea (South)
ID NLM: 100890690
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
29
10
2021
revised:
15
03
2022
accepted:
02
05
2022
entrez:
16
1
2023
pubmed:
17
1
2023
medline:
17
1
2023
Statut:
ppublish
Résumé
Although many studies have evaluated the efficacy and pharmacokinetics of Korean Red Ginseng (KRG) components (Rg1, Rb1, Rg3, Rd, etc.), few have examined the in vivo pharmacokinetics of the radiolabeled components. This study investigated the pharmacokinetics of ginsenosides and their metabolite compound K (CK), 20(s)-protopanaxadiol (PPD), and 20(s)-protopanaxatriol (PPT) using radioisotopes in rat oral administration. Sprague-Dawley rats were dosed orally once with 10 mg/kg of the tritium(3H) radiolabeled samples, and then the blood was collected from the tail vein after 0.25, 0.5, 1, 1.5, 2, 4, 6, 8, 12, 24, 48, 96, and 168 h. Radioactivity in the organs, feces, urine, and carcass was determined using a liquid scintillation counter (LSC) and a bio-imaging analyzer system (BAS). After oral administration, as the
Sections du résumé
Background
UNASSIGNED
Although many studies have evaluated the efficacy and pharmacokinetics of Korean Red Ginseng (KRG) components (Rg1, Rb1, Rg3, Rd, etc.), few have examined the in vivo pharmacokinetics of the radiolabeled components. This study investigated the pharmacokinetics of ginsenosides and their metabolite compound K (CK), 20(s)-protopanaxadiol (PPD), and 20(s)-protopanaxatriol (PPT) using radioisotopes in rat oral administration.
Methods
UNASSIGNED
Sprague-Dawley rats were dosed orally once with 10 mg/kg of the tritium(3H) radiolabeled samples, and then the blood was collected from the tail vein after 0.25, 0.5, 1, 1.5, 2, 4, 6, 8, 12, 24, 48, 96, and 168 h. Radioactivity in the organs, feces, urine, and carcass was determined using a liquid scintillation counter (LSC) and a bio-imaging analyzer system (BAS).
Results and conclusion
UNASSIGNED
After oral administration, as the
Identifiants
pubmed: 36644381
doi: 10.1016/j.jgr.2022.05.001
pii: S1226-8453(22)00060-4
pmc: PMC9834004
doi:
Types de publication
Journal Article
Langues
eng
Pagination
74-80Informations de copyright
© 2022 The Korean Society of Ginseng. Publishing services by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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